Product image of Montelukast Accord (Montelukast Sodium) supplied by GNH India

Montelukast Accord

Active Ingredient:
Montelukast Sodium
Origin:
EU

Montelukast Accord (Montelukast Sodium)

Montelukast, the active ingredient in Montelukast Accord, is a leukotriene receptor antagonist presented as an oral tablet for oral use. It is used to manage asthma, allergic rhinitis, and exercise‑induced bronchoconstriction in adults and children as maintenance therapy.

GNH India supplies Montelukast Accord as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Accord Healthcare B.V.

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Indications & Clinical Uses

  • Montelukast acts on the leukotriene pathway to control inflammatory airway conditions.
  • Asthma: reduces frequency of wheezing episodes and improves lung function.
  • Allergic rhinitis: alleviates nasal congestion, sneezing and itching.
  • Exercise‑induced bronchoconstriction: prevents bronchospasm triggered by physical activity.

How It Works

  • Montelukast selectively blocks the cysteinyl leukotriene receptor CysLT1, preventing leukotriene D4 from binding. This inhibition reduces bronchoconstriction, vascular permeability, and eosinophil recruitment, thereby decreasing airway inflammation and hyper‑responsiveness associated with asthma and allergic rhinitis.

Side Effects

Montelukast is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Headache
  • Abdominal pain
  • Nausea
  • Cough
  • Sore throat
  • Fatigue

Serious or Rare Side Effects

  • Angioedema or anaphylaxis
  • Mood changes, including depression or suicidal thoughts
  • Elevated liver enzymes
  • Severe rash or Stevens‑Johnson syndrome
  • Eosinophilic pneumonia
  • Hematologic abnormalities

Precautions & Warnings

  • Before prescribing Montelukast, clinicians should consider several safety aspects.
  • Assess asthma control before initiating: ensure patient is on appropriate inhaled therapy.
  • Monitor for neuropsychiatric symptoms: report mood changes, depression, or suicidal thoughts.
  • Use caution in patients with hepatic impairment: adjust if needed.
  • Avoid use in patients with known hypersensitivity to montelukast or any excipient.
  • Consider drug interactions: review concomitant medications.
  • Store at ambient temperature below 25°C: keep in original packaging, protect from moisture.

Avoid Interactions

Montelukast may interact with several medicines; awareness of interaction severity helps guide monitoring.

Major Interactions (Avoid)

  • Phenobarbital: may reduce plasma concentrations of montelukast.
  • Rifampin: may decrease effectiveness of montelukast.
  • Ketoconazole: may increase montelukast levels, raising risk of side effects.

Moderate Interactions (Monitor Closely)

  • Warfarin: may alter INR; monitor coagulation parameters.
  • Beta‑agonists: additive bronchodilation effect; observe clinical response.
  • Antidepressants (SSRIs): monitor for neuropsychiatric events.

Frequently Asked Questions

Montelukast Accord contains the leukotriene receptor antagonist montelukast sodium and is prescribed for maintenance therapy of asthma, relief of allergic rhinitis symptoms, and prevention of exercise‑induced bronchoconstriction in both adult and pediatric patients.

Montelukast selectively blocks the cysteinyl leukotriene receptor CysLT1, preventing leukotriene D4 from triggering bronchoconstriction, mucus secretion, and inflammatory cell recruitment, which together reduce airway narrowing and allergic inflammation.

The specific dose is determined by the prescribing clinician based on the patient’s age, weight, and clinical condition. Typical regimens range from once‑daily tablets, but exact strength and frequency must be individualized by a healthcare professional.

Safety data for montelukast in pregnancy and lactation are limited. The drug should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision must be made by the prescriber after evaluating the clinical situation.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Montelukast belongs to the leukotriene receptor antagonist class, offering an oral alternative to inhaled corticosteroids or long‑acting beta‑agonists for asthma control. Compared with other leukotriene antagonists such as zafirlukast, montelukast has a once‑daily dosing schedule and a broader approval for allergic rhinitis.

Montelukast Accord should be stored at ambient temperature below 25 °C, in its original container, protected from moisture and direct sunlight. Keep the product out of reach of children and avoid exposure to extreme heat or humidity.

The medication is taken orally as a tablet, swallowed whole with a glass of water. It may be taken with or without food, and the dose is usually administered once daily at the same time each day for consistent blood levels.

Serious adverse events include allergic reactions such as angioedema or anaphylaxis, neuropsychiatric effects like depression or suicidal thoughts, and rare hepatic injury. Patients should be instructed to seek immediate medical attention if they experience any of these symptoms.

Montelukast is contraindicated in individuals with known hypersensitivity to montelukast sodium or any of the tablet’s excipients. Caution is also advised for patients with severe hepatic impairment or those who have experienced previous serious reactions to leukotriene receptor antagonists.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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