Product image of Montelukast Actavis (Montelukast) supplied by GNH India

Montelukast Actavis

Active Ingredient:
Montelukast
Origin:
EU

Montelukast Actavis (Montelukast)

Montelukast, the active ingredient in Montelukast Actavis, is a leukotriene receptor antagonist presented as an oral tablet for oral use. It is used to manage asthma, allergic rhinitis, and exercise‑induced bronchoconstriction in adults and children.
GNH India supplies Montelukast Actavis as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Actavis Group Ptc Ehf.

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Indications & Clinical Uses

Montelukast acts on the leukotriene pathway to control chronic airway disorders.

  • Asthma: improves control of persistent asthma and reduces exacerbations.
  • Allergic rhinitis: alleviates nasal congestion, sneezing and itching caused by seasonal or perennial allergies.
  • Exercise‑induced bronchoconstriction: prevents airway narrowing that occurs during or after physical activity.

How It Works

  • Montelukast selectively blocks the cysteinyl leukotriene receptor CysLT1, preventing leukotrienes D4, E4 and related mediators from binding. This inhibition reduces bronchoconstriction, airway inflammation and mucus secretion, thereby improving airflow and symptom control in leukotriene‑driven respiratory conditions.

Side Effects

Montelukast is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Upper respiratory tract infection: transient symptoms.
  • Abdominal pain: occasional discomfort.
  • Cough: non‑productive.
  • Diarrhea: mild episodes.
  • Rash: mild skin irritation.

Serious or Rare Side Effects

  • Mood changes: including depression or suicidal thoughts.
  • Allergic reactions: such as angioedema or anaphylaxis.
  • Hepatotoxicity: elevated liver enzymes.
  • Severe skin reactions: Stevens‑Johnson syndrome.
  • Blood dyscrasias: rare cases of neutropenia.

Precautions & Warnings

Before initiating therapy, consider the following safety measures.

  • Pregnancy: safety not established; discuss risks with a healthcare professional.
  • Breastfeeding: assess benefit‑risk balance before use.
  • Hepatic impairment: monitor liver function in patients with existing liver disease.
  • Psychiatric history: observe for mood alterations or suicidal ideation.
  • Concomitant asthma therapy: do not replace inhaled corticosteroids with Montelukast alone.
  • Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Montelukast may interact with other medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

  • Phenobarbital: may lower Montelukast plasma concentrations.
  • Rifampin: induces metabolism, potentially reducing therapeutic effect.

Moderate Interactions (Monitor Closely)

  • Antidepressants (e.g., fluoxetine): monitor for mood changes.
  • Antihistamines: may increase sedation when combined.
  • CYP3A4 inhibitors (e.g., ketoconazole): observe for possible increased Montelukast levels.

Frequently Asked Questions

Montelukast Actavis is prescribed to treat persistent asthma, allergic rhinitis (both seasonal and perennial), and exercise‑induced bronchoconstriction. It helps control airway inflammation and reduces symptoms such as wheezing, nasal congestion, and exercise‑related breathing difficulties.

Montelukast blocks the cysteinyl leukotriene receptor CysLT1, preventing leukotrienes D4, E4 and related mediators from binding. This action reduces bronchoconstriction, airway inflammation, and mucus production, leading to improved airflow and symptom relief in leukotriene‑driven respiratory diseases.

The specific dose of Montelukast Actavis is determined by the prescribing clinician based on the patient’s age, condition severity, and response to therapy. Healthcare providers set the appropriate regimen and adjust it as needed.

Safety data for Montelukast Actavis in pregnancy are limited, and the product is classified as pregnancy category unknown. It should only be used if the potential benefit justifies the potential risk. During breastfeeding, a risk‑benefit assessment is also required, and the prescriber should decide whether to continue treatment.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Montelukast is a leukotriene receptor antagonist, whereas inhaled corticosteroids are anti‑inflammatory agents that act directly on airway cells. Montelukast is often used as an add‑on therapy for patients whose asthma is not fully controlled by inhaled steroids, but it does not replace the anti‑inflammatory effect of corticosteroids.

Montelukast Actavis tablets should be stored at temperatures below 25 °C. Keep them in the original container, protect from moisture and direct sunlight, and avoid storing in areas with high humidity or heat.

Montelukast Actavis is taken orally, usually as a whole tablet with or without food. The exact timing (e.g., morning or evening) is decided by the prescriber based on the patient’s treatment plan.

Serious risks include mood changes such as depression or suicidal thoughts, severe allergic reactions (e.g., angioedema, anaphylaxis), and rare but serious skin reactions like Stevens‑Johnson syndrome. Patients should be monitored for any new or worsening psychiatric symptoms or allergic signs.

Montelukast Actavis should be avoided in patients with known hypersensitivity to montelukast or any of the tablet’s excipients. Caution is also advised for individuals with a history of severe psychiatric disorders, liver disease, or those taking medications that may cause major drug interactions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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