Product image of Montelukast Alvogen (Montelukast) supplied by GNH India

Montelukast Alvogen

Active Ingredient:
Montelukast
Origin:
EU

Montelukast Alvogen (Montelukast)

Montelukast, the active ingredient in Montelukast Alvogen, is a leukotriene receptor antagonist presented as an oral dosage form for oral use. It is employed to manage asthma, allergic rhinitis and exercise‑induced bronchoconstriction in adults and children.

GNH India supplies Montelukast Alvogen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Alvogen Ehf

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Indications & Clinical Uses

Montelukast is a leukotriene‑targeting medication used in several respiratory and allergic conditions.

  • Asthma (maintenance therapy): reduces the frequency of wheezing, shortness of breath and nighttime symptoms.
  • Allergic rhinitis: alleviates nasal congestion, sneezing and itchy eyes caused by seasonal allergens.
  • Exercise‑induced bronchoconstriction: prevents airway narrowing that occurs during physical activity, improving exercise tolerance.

How It Works

  • Montelukast selectively blocks the cysteinyl leukotriene receptor CysLT1 on airway smooth muscle and inflammatory cells. By antagonizing this receptor, it inhibits the actions of leukotrienes that cause bronchoconstriction, mucus secretion, vascular permeability, and eosinophilic inflammation, thereby improving airway patency and reducing allergic inflammation.

Side Effects

Montelukast is generally well tolerated, but a range of adverse reactions have been reported.

Common Side Effects

  • Headache
  • Abdominal pain
  • Cough
  • Nausea
  • Fatigue
  • Dizziness

Serious or Rare Side Effects

  • Allergic reactions such as rash, angioedema, or anaphylaxis
  • Mood changes including depression or suicidal thoughts
  • Hepatic enzyme elevations
  • Severe skin reactions (e.g., Stevens‑Johnson syndrome)
  • Eosinophilic pneumonia
  • Unexplained fever or systemic hypersensitivity

Precautions & Warnings

Before initiating therapy, consider the following safety points.

  • Pregnancy: consult a healthcare professional because safety data are limited.
  • Breastfeeding: weigh potential benefits against unknown risks to the infant.
  • Concomitant phenobarbital or strong CYP3A4 inducers: may reduce drug exposure, requiring monitoring.
  • Liver impairment: monitor hepatic function, especially in severe disease.
  • Elderly patients: use with caution due to possible increased sensitivity.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct heat.

Avoid Interactions

Montelukast can interact with several medicines, affecting efficacy or safety.

Major Interactions (Avoid)

  • Phenobarbital: may markedly decrease montelukast plasma concentrations.
  • Rifampin: can reduce therapeutic effect by inducing metabolism.
  • Strong CYP3A4 inducers (e.g., carbamazepine): may lower drug exposure.

Moderate Interactions (Monitor Closely)

  • Antidepressants (SSRIs, SNRIs): monitor for mood changes or suicidal ideation.
  • ACE inhibitors: potential increased risk of angioedema.
  • Beta‑agonists: no direct pharmacokinetic interaction, but clinical response should be observed.

Frequently Asked Questions

Montelukast Alvogen is indicated for maintenance therapy of asthma, relief of symptoms of allergic rhinitis, and prevention of exercise‑induced bronchoconstriction. It works by blocking leukotriene receptors that contribute to airway narrowing and inflammation, helping patients achieve better respiratory control.

Montelukast selectively antagonizes the cysteinyl leukotriene receptor CysLT1 on airway smooth muscle and inflammatory cells. By blocking this receptor, it prevents leukotriene‑mediated bronchoconstriction, mucus production, and eosinophilic inflammation, thereby improving airflow and reducing allergic symptoms.

The appropriate dose of Montelukast Alvogen is determined by the prescribing clinician based on the patient’s age, condition, and response to therapy. Healthcare providers follow established guidelines and adjust the regimen as needed for optimal control.

Safety data for Montelukast in pregnancy are limited, so it should only be used if the potential benefit justifies the risk. During breastfeeding, the drug passes into milk in small amounts; clinicians should weigh maternal benefits against possible infant exposure.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Montelukast belongs to the leukotriene receptor antagonist class, offering an oral alternative to inhaled corticosteroids or long‑acting beta‑agonists. It is particularly useful for patients with aspirin‑exacerbated respiratory disease or those who prefer a non‑inhaled option, though it may be less potent for acute symptom relief.

Montelukast Alvogen should be stored at ambient temperature, below 25 °C. Keep the tablets in the original packaging, protect them from moisture, direct sunlight and excessive heat to maintain stability.

Montelukast Alvogen is taken orally, usually once daily in the evening, with or without food. The tablet should be swallowed whole with a glass of water; it is not intended for crushing or chewing.

Serious risks include severe allergic reactions such as rash, angioedema, or anaphylaxis, as well as neuropsychiatric events like depression, suicidal thoughts, and mood changes. Patients should seek immediate medical attention if they experience any of these symptoms.

Montelukast Alvogen is contraindicated in individuals with known hypersensitivity to montelukast or any component of the formulation. Caution is advised for patients with severe liver disease, active psychiatric conditions, or those taking interacting medications without appropriate monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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