Product image of Montelukast Cinfa (Montelukast) supplied by GNH India

Montelukast Cinfa

Active Ingredient:
Montelukast
Origin:
EU

Montelukast Cinfa (Montelukast)

Montelukast, the active ingredient in Montelukast Cinfa, is a leukotriene receptor antagonist presented as an oral tablet for oral use. It is used to manage asthma and allergic rhinitis in adults and children as part of maintenance therapy.

GNH India supplies Montelukast Cinfa as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Laboratorios Cinfa S.A.

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Indications & Clinical Uses

Montelukast acts on the leukotriene pathway to control inflammatory airway conditions.

  • Asthma (maintenance therapy): reduces frequency of bronchospasm and improves overall asthma control.
  • Allergic rhinitis: alleviates nasal congestion, sneezing, itching and rhinorrhea.
  • Exercise‑induced bronchoconstriction: helps prevent airway narrowing triggered by physical activity.

How It Works

  • Montelukast selectively blocks the cysteinyl leukotriene receptor CysLT1, preventing leukotrienes D4, E4 and related cysteinyl leukotrienes from binding. This inhibition reduces bronchial smooth‑muscle contraction, vascular permeability, mucus secretion and inflammatory cell recruitment, thereby improving airway patency and reducing allergic inflammation.

Side Effects

Montelukast is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Abdominal pain: occasional discomfort.
  • Cough: transient irritation.
  • Dyspepsia: indigestion or upset stomach.
  • Fever: low‑grade temperature elevation.
  • Sore throat: mild irritation.

Serious or Rare Side Effects

  • Allergic reactions: rash, angioedema or anaphylaxis.
  • Neuropsychiatric events: mood changes, depression or suicidal thoughts.
  • Liver enzyme elevation: abnormal hepatic function tests.
  • Stevens‑Johnson syndrome: severe skin eruption.
  • Eosinophilic granulomatosis with polyangiitis: rare vasculitis.
  • Severe rash: widespread cutaneous eruptions.

Precautions & Warnings

Montelukast should be used with awareness of specific safety considerations.

  • Pregnancy: safety not established; use only if benefit outweighs risk.
  • Breastfeeding: unknown; consider potential infant exposure.
  • Hepatic impairment: use with caution and monitor liver function.
  • Concomitant enzyme inducers: phenobarbital or rifampin may lower drug levels.
  • Neuropsychiatric symptoms: monitor for mood changes or suicidal thoughts.
  • Store below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Montelukast may interact with other medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

  • Phenobarbital: may decrease plasma concentrations of montelukast.
  • Rifampin: can reduce therapeutic effect.
  • Strong CYP3A4 inducers: may lower drug exposure.

Moderate Interactions (Monitor Closely)

  • Warfarin: may increase INR; monitor coagulation.
  • Theophylline: potential increase in serum levels.
  • Zafirlukast: additive leukotriene inhibition; observe for enhanced effects.

Frequently Asked Questions

Montelukast Cinfa is prescribed for the long‑term management of asthma, for relief of symptoms associated with allergic rhinitis, and to prevent exercise‑induced bronchoconstriction. It works as part of a maintenance regimen to reduce airway inflammation and improve breathing.

Montelukast blocks the cysteinyl leukotriene receptor CysLT1, preventing leukotrienes D4, E4 and related molecules from triggering bronchial smooth‑muscle contraction, mucus production and vascular leakage. This inhibition reduces airway narrowing and allergic inflammation.

The appropriate dose of Montelukast Cinfa is determined by the prescribing clinician based on the patient’s age, weight, condition severity and other medical factors. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for Montelukast in pregnancy are limited, and the product is classified as having an unknown pregnancy category. It should only be used if the potential benefit justifies the risk. Information on use while breastfeeding is also insufficient, so a risk‑benefit assessment is required.

To request Montelukast Cinfa, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Montelukast belongs to the leukotriene receptor antagonist class, offering an oral alternative to inhaled corticosteroids or long‑acting beta‑agonists. It is particularly useful for patients with aspirin‑sensitive asthma or those who prefer a once‑daily tablet, but it may be less potent for acute symptom relief compared with inhaled bronchodilators.

Montelukast Cinfa should be stored at temperatures below 25 °C, in its original packaging, and protected from moisture and direct sunlight. Keeping the product in a dry, cool environment helps maintain its stability and potency.

Montelukast Cinfa is taken orally, usually once daily in the evening, with or without food. The tablet should be swallowed whole with a glass of water and not crushed or chewed unless specifically instructed by a healthcare professional.

Serious risks include rare allergic reactions such as angioedema or anaphylaxis, neuropsychiatric events like depression or suicidal thoughts, and severe skin reactions such as Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience any of these symptoms.

Montelukast Cinfa is contraindicated in individuals with known hypersensitivity to montelukast or any of the tablet’s excipients. Patients with a history of severe allergic reactions to leukotriene‑modifying agents should avoid this medication.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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