Product image of Montelukast Cinfa (Montelukast Sodium) supplied by GNH India

Montelukast Cinfa

Active Ingredient:
Montelukast Sodium
Origin:
EU

Montelukast Cinfa (Montelukast Sodium)

Montelukast Sodium, the active ingredient in Montelukast Cinfa, is a leukotriene receptor antagonist presented as an oral dosage form for oral use. It is employed in the maintenance therapy of asthma and for the relief of symptoms associated with seasonal and perennial allergic rhinitis in adults and children.

GNH India supplies Montelukast Cinfa as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Laboratorios Cinfa S.A.

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Indications & Clinical Uses

Montelukast Cinfa acts on the leukotriene pathway to control chronic airway and nasal inflammation.

  • Asthma: reduces the frequency of bronchospasm episodes and improves overall asthma control.
  • Seasonal allergic rhinitis: alleviates nasal congestion, sneezing and itching during pollen seasons.
  • Perennial allergic rhinitis: provides sustained relief of nasal symptoms year‑round.

How It Works

  • Montelukast Sodium selectively antagonizes the cysteinyl leukotriene receptor CysLT1, blocking the action of leukotriene D4. This inhibition prevents leukotriene‑mediated bronchoconstriction, vascular permeability, and inflammatory cell recruitment, thereby reducing airway narrowing and nasal mucosal edema associated with asthma and allergic rhinitis.

Side Effects

Montelukast Cinfa may cause a range of adverse reactions.

Common Side Effects

  • Headache
  • Abdominal pain
  • Cough
  • Nausea
  • Dizziness
  • Fatigue

Serious or Rare Side Effects

  • Angioedema or severe allergic reactions
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis
  • Eosinophilic granulomatosis with polyangiitis (Churg‑Strauss syndrome)
  • Hepatic injury
  • Suicidal thoughts or other neuropsychiatric events
  • Anaphylaxis

Precautions & Warnings

Before initiating therapy, clinicians should consider several safety aspects.

  • Assess asthma control: ensure baseline control before adding Montelukast.
  • Monitor neuropsychiatric symptoms: watch for mood changes, depression, or suicidal ideation.
  • Use with caution in hepatic impairment: dose adjustment may be required.
  • Avoid in patients with known hypersensitivity to Montelukast or any excipients.
  • Review concomitant medications for potential interactions.
  • Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Montelukast Cinfa can interact with other medicines that affect its metabolism or leukotriene pathways.

Major Interactions (Avoid)

  • Rifampin: strong CYP3A4 inducer that may reduce Montelukast exposure and effectiveness.
  • Phenobarbital: enzyme inducer that can lower plasma concentrations of Montelukast.

Moderate Interactions (Monitor Closely)

  • Ketoconazole: CYP3A4 inhibitor that may increase Montelukast levels.
  • Fluconazole: moderate CYP3A4 inhibitor, may raise exposure.
  • Zafirlukast: concurrent leukotriene receptor blockade can increase risk of adverse effects.

Frequently Asked Questions

Montelukast Cinfa is prescribed for the long‑term management of asthma and for the relief of symptoms associated with seasonal and perennial allergic rhinitis. It helps reduce airway narrowing and nasal inflammation, improving breathing and nasal comfort in patients with these chronic respiratory conditions.

Montelukast Sodium works by selectively blocking the cysteinyl leukotriene receptor CysLT1. By preventing leukotriene D4 from binding, it stops the cascade that leads to bronchoconstriction, mucus production, and inflammatory cell recruitment, thereby easing airway and nasal passage inflammation.

The specific dose of Montelukast Cinfa is determined by the prescribing healthcare professional based on the patient’s age, condition severity, and response to therapy. Clinicians follow approved dosing guidelines, but the exact regimen should always be individualized and confirmed by the prescriber.

Safety data for Montelukast Cinfa in pregnancy and lactation are limited. The product should only be used if the potential benefit justifies any potential risk to the fetus or infant. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss risks and alternatives with their healthcare provider.

To place an order, submit an enquiry on the Montelukast Cinfa product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any special handling) and necessary import documentation.

Montelukast belongs to the leukotriene receptor antagonist class, offering an oral alternative to inhaled corticosteroids or other leukotriene blockers such as zafirlukast. Compared with inhaled steroids, Montelukast provides systemic coverage without the need for inhalation devices, though it may be less potent for acute symptom relief. It is often used as add‑on therapy or when inhaled options are unsuitable.

Montelukast Cinfa should be stored at temperatures below 25 °C. Keep the product in its original packaging, protect it from moisture, excessive heat, and direct sunlight. Do not store in a bathroom or near a kitchen sink where humidity is high.

Montelukast Cinfa is taken orally, usually as a tablet. The tablet should be swallowed whole with a glass of water and can be taken with or without food. Patients should follow the dosing schedule prescribed by their healthcare professional.

Serious risks include neuropsychiatric events such as depression, suicidal thoughts, or mood changes, as well as severe allergic reactions like angioedema, anaphylaxis, and rare skin conditions such as Stevens‑Johnson syndrome. Any sudden or severe symptoms should prompt immediate medical evaluation.

Montelukast Cinfa should be avoided in individuals with known hypersensitivity to Montelukast Sodium or any of the tablet’s excipients. Caution is also advised for patients with severe hepatic impairment or those taking interacting medications that could significantly alter drug levels.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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