Product image of Montelukast Doc (Montelukast) supplied by GNH India

Montelukast Doc

Active Ingredient:
Montelukast
Origin:
EU

Montelukast Doc (Montelukast)

Montelukast, the active ingredient in Montelukast Doc, is a leukotriene receptor antagonist presented as an oral tablet for oral use. It is prescribed to manage asthma, exercise‑induced bronchoconstriction, and allergic rhinitis in patients who require control of airway inflammation and bronchospasm.

GNH India supplies Montelukast Doc as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Doc Generici S.R.L.

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Indications & Clinical Uses

Montelukast acts on the leukotriene pathway to reduce airway inflammation and bronchoconstriction.

  • Asthma: improves long‑term control and reduces frequency of exacerbations.
  • Exercise‑induced bronchoconstriction: prevents narrowing of airways triggered by physical activity.
  • Allergic rhinitis: alleviates nasal congestion, sneezing and itching caused by allergic inflammation.

How It Works

  • Montelukast selectively antagonizes the cysteinyl leukotriene receptor CysLT1, blocking the actions of leukotrienes D4, C4, and E4. By inhibiting this receptor, it prevents leukotriene‑mediated bronchoconstriction, vascular permeability, and eosinophil recruitment, thereby reducing airway inflammation and hyper‑responsiveness associated with asthma and allergic rhinitis.

Side Effects

Montelukast is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Upper respiratory tract infection: transient symptoms.
  • Abdominal pain or dyspepsia: occasional discomfort.
  • Mood changes: irritability or mild anxiety.

Serious or Rare Side Effects

  • Allergic reactions: rash, angioedema, or anaphylaxis.
  • Neuropsychiatric events: depression, suicidal thoughts, or hallucinations.
  • Hepatotoxicity: elevated liver enzymes or jaundice.

Precautions & Warnings

Before initiating therapy, consider the following precautions.

  • Pregnancy: Category B – use only if clearly needed after risk‑benefit assessment.
  • Breastfeeding: small amounts excreted in milk; weigh benefits to infant against potential risk.
  • Hepatic impairment: monitor liver function in patients with pre‑existing liver disease.
  • Concomitant asthma therapy: do not replace inhaled corticosteroids or bronchodilators without medical guidance.
  • Store at ambient temperature: keep below 25°C, retain in original packaging, and protect from moisture.

Avoid Interactions

Montelukast may interact with several drug classes.

Major Interactions (Avoid)

  • Phenobarbital or rifampin: may reduce montelukast plasma concentrations, compromising efficacy.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole): can increase exposure, raising risk of adverse effects.

Moderate Interactions (Monitor Closely)

  • Warfarin: occasional reports of altered INR; monitor coagulation parameters.
  • Antidepressants (SSRIs, SNRIs): potential additive neuropsychiatric effects; observe mood changes.

Frequently Asked Questions

Montelukast Doc is prescribed to manage chronic asthma, prevent exercise‑induced bronchoconstriction, and relieve symptoms of allergic rhinitis such as nasal congestion, sneezing, and itching. It works by targeting leukotriene‑mediated inflammation in the airways.

Montelukast blocks the cysteinyl leukotriene receptor CysLT1, preventing leukotrienes D4, C4, and E4 from binding. This inhibition reduces bronchoconstriction, vascular leakage, and eosinophil recruitment, leading to decreased airway inflammation and improved breathing.

The specific dose of Montelukast Doc is determined by the prescribing clinician based on the patient’s age, condition severity, and treatment goals. Dosage adjustments are individualized and should follow the prescriber’s instructions.

Montelukast is classified as Pregnancy Category B, indicating no evidence of risk in animal studies but limited human data. It is excreted in breast milk in small amounts; use only if the potential benefit justifies any possible risk to the infant.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Montelukast and inhaled corticosteroids act via different mechanisms; montelukast blocks leukotriene receptors, while corticosteroids suppress broad inflammatory pathways. Montelukast is often used as an add‑on therapy for patients who need additional control, but it does not replace inhaled steroids for persistent asthma.

Montelukast Doc should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in their original container, protect them from moisture and direct sunlight, and ensure the packaging remains tightly closed.

Montelukast Doc is taken orally, usually once daily in the evening, with or without food. The tablet should be swallowed whole with a glass of water; it should not be crushed, chewed, or split unless specifically instructed by a healthcare professional.

Serious risks include rare neuropsychiatric events such as depression, suicidal thoughts, or hallucinations, and allergic reactions that may manifest as rash, angioedema, or anaphylaxis. Patients should seek immediate medical attention if they experience any of these symptoms.

Montelukast Doc is contraindicated in individuals with known hypersensitivity to montelukast or any of its excipients. Caution is advised for patients with severe hepatic impairment, and it should not be used as a sole rescue medication for acute asthma attacks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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