Product image of Montelukast Dorom (Montelukast) supplied by GNH India

Montelukast Dorom

Active Ingredient:
Montelukast
Origin:
EU

Montelukast Dorom (Montelukast)

Montelukast, the active ingredient in Montelukast Dorom, is a leukotriene receptor antagonist presented as a tablet for oral use. It helps control asthma symptoms and allergic rhinitis in adults and children by reducing airway inflammation and nasal congestion.

GNH India supplies Montelukast Dorom as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva Italia S.R.L.

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Indications & Clinical Uses

  • Montelukast acts on the leukotriene pathway to manage chronic respiratory and allergic conditions.
  • Asthma: reduces frequency of wheezing episodes and improves lung function.
  • Allergic rhinitis: alleviates nasal congestion, sneezing and itching.
  • Exercise‑induced bronchoconstriction: prevents airway narrowing after physical activity.

How It Works

  • Montelukast selectively blocks the cysteinyl leukotriene receptor CysLT1, preventing leukotrienes D4, E4 and I4 from binding. This inhibition reduces bronchoconstriction, vascular permeability, mucus secretion, and inflammatory cell recruitment in the airways, thereby improving respiratory function and decreasing allergic inflammation.

Side Effects

Montelukast is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Headache
  • Abdominal pain
  • Nausea
  • Fatigue

Serious or Rare Side Effects

  • Allergic reactions such as angioedema or anaphylaxis
  • Neuropsychiatric events including mood changes or suicidal thoughts
  • Hepatic enzyme elevation
  • Severe skin reactions such as Stevens‑Johnson syndrome

Precautions & Warnings

Before prescribing Montelukast, clinicians should consider several safety aspects.

  • Liver function monitoring: assess hepatic status in patients with known liver disease.
  • Neuropsychiatric vigilance: watch for mood changes, depression or suicidal ideation.
  • Caution in severe hepatic impairment: dose adjustment may be required.
  • Hypersensitivity: avoid in individuals with known allergy to Montelukast or excipients.
  • Store at below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Montelukast may interact with other medicines, requiring attention to potential effects.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine) that may lower Montelukast exposure.
  • Concurrent use with other leukotriene modifiers (e.g., zafirlukast) due to additive pharmacologic activity.
  • Phenobarbital, which can increase metabolic clearance.

Moderate Interactions (Monitor Closely)

  • SSRIs or other antidepressants that may heighten neuropsychiatric risk.
  • Beta‑agonists where combined bronchodilation could enhance effects.
  • Warfarin, as Montelukast may modestly affect anticoagulant control.

Frequently Asked Questions

Montelukast Dorom is prescribed to manage chronic asthma, allergic rhinitis, and exercise‑induced bronchoconstriction. By blocking leukotriene receptors, it helps reduce airway narrowing, inflammation, and nasal symptoms, improving breathing and quality of life for patients with these respiratory and allergic disorders.

Montelukast selectively antagonizes the cysteinyl leukotriene receptor CysLT1. This prevents leukotrienes D4, E4 and I4 from triggering bronchoconstriction, mucus production, and vascular leakage in the airways, thereby decreasing inflammation and easing breathing difficulties associated with asthma and allergic rhinitis.

The specific dose of Montelukast Dorom is determined by the prescribing clinician based on the patient’s age, weight, severity of disease, and response to therapy. Healthcare professionals follow approved labeling and clinical guidelines to set an appropriate regimen for each individual.

Safety data for Montelukast in pregnancy and lactation are limited. Clinicians should weigh potential benefits against possible risks and consider alternative treatments when possible. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss use with their healthcare provider.

To request Montelukast Dorom, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Montelukast belongs to the leukotriene receptor antagonist class, offering an oral alternative to inhaled corticosteroids or long‑acting beta‑agonists. It is particularly useful for patients with aspirin‑sensitive asthma or those who need additional control of allergic rhinitis, though it may be less potent than inhaled steroids for severe asthma.

Montelukast Dorom tablets should be stored at temperatures below 25 °C, in the original packaging, and protected from moisture and direct sunlight. Maintaining these conditions helps preserve potency and ensures product stability throughout its shelf life.

Montelukast Dorom is taken orally, usually as a whole tablet with or without food. The exact timing (morning or evening) and frequency are set by the prescriber, who tailors the regimen to the patient’s therapeutic needs and lifestyle.

Serious risks include rare allergic reactions such as angioedema or anaphylaxis, neuropsychiatric events like mood changes or suicidal thoughts, and severe skin reactions such as Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience any of these symptoms.

Montelukast Dorom is contraindicated in individuals with known hypersensitivity to Montelukast or any of its excipients. Caution is also advised for patients with severe hepatic impairment, and it should be avoided in those who have experienced serious allergic reactions to other leukotriene‑modifying agents.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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