Product image of Montelukast Evolugen (Montelukast Sodium) supplied by GNH India

Montelukast Evolugen

Active Ingredient:
Montelukast Sodium
Origin:
EU

Montelukast Evolugen (Montelukast Sodium)

Montelukast Sodium, the active ingredient in Montelukast Evolugen, is a leukotriene receptor antagonist presented as an oral tablet for oral use. It is indicated for maintenance therapy of asthma, relief of allergic rhinitis symptoms, and prevention of exercise‑induced bronchoconstriction in appropriate patients.

GNH India supplies Montelukast Evolugen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Evolupharm

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Indications & Clinical Uses

  • Montelukast Evolugen acts on the leukotriene pathway to control inflammatory airway conditions.
  • Asthma: reduces frequency of bronchospasm and improves long‑term control.
  • Allergic rhinitis: alleviates nasal congestion, sneezing and itching.
  • Exercise‑induced bronchoconstriction: prevents airway narrowing during physical activity.

How It Works

  • Montelukast Sodium selectively blocks cysteinyl leukotriene (CysLT1) receptors, preventing leukotrienes D4, E4 and related mediators from binding. This inhibition reduces bronchoconstriction, mucus secretion, vascular permeability and inflammatory cell recruitment in the respiratory tract, thereby improving airway patency and symptom control.

Side Effects

Montelukast is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Headache
  • Abdominal pain
  • Cough
  • Dyspepsia
  • Nausea
  • Fatigue

Serious or Rare Side Effects

  • Angioedema or severe allergic reactions
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis
  • Eosinophilic granulomatosis with polyangiitis
  • Hepatic injury
  • Anaphylaxis
  • Neuropsychiatric events such as mood changes or suicidal thoughts

Precautions & Warnings

  • Before initiating therapy, consider the following precautions.
  • Liver function: assess hepatic status in patients with known liver disease.
  • Neuropsychiatric monitoring: watch for mood alterations, depression or suicidal ideation.
  • Pregnancy: safety category is unknown; discuss risks with a healthcare professional.
  • Hypersensitivity: avoid in individuals with known allergy to montelukast or any tablet excipients.
  • Drug interactions: review concomitant medications for potential interactions.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Montelukast may interact with several medicines; categorize interactions accordingly.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir) may increase plasma levels.
  • Phenobarbital or rifampicin (CYP inducers) can markedly reduce efficacy.
  • Erythromycin (CYP3A4 inhibitor) may elevate drug concentrations.

Moderate Interactions (Monitor Closely)

  • Warfarin: potential alteration of INR; monitor coagulation parameters.
  • Theophylline: possible increase in serum levels; observe for toxicity.
  • Beta‑agonists: additive bronchodilatory effect; adjust dosing if needed.

Frequently Asked Questions

Montelukast Evolugen is prescribed for the long‑term management of asthma, to relieve symptoms of seasonal or perennial allergic rhinitis, and to prevent exercise‑induced bronchoconstriction. It works by targeting inflammatory mediators that cause airway narrowing, making it useful in patients who need daily control of these respiratory conditions.

Montelukast blocks cysteinyl leukotriene (CysLT1) receptors in the airways. By preventing leukotrienes D4, E4 and related compounds from binding, it reduces bronchoconstriction, mucus production, and inflammation. This receptor antagonism helps keep the airways open and diminishes allergic and exercise‑related respiratory symptoms.

The dosage of Montelukast Evolugen is determined by the prescribing healthcare professional based on the patient’s age, weight, and clinical condition. Typical adult regimens involve a once‑daily tablet, but exact strength and frequency must be confirmed by the prescriber and reflected on the prescription label.

Safety data for Montelukast during pregnancy and lactation are limited, and the product carries an unknown pregnancy category. Healthcare providers should weigh potential benefits against possible risks and discuss alternative options. Women who are pregnant, planning pregnancy, or breastfeeding should consult their physician before starting therapy.

To place an order, submit an enquiry on the Montelukast Evolugen product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Montelukast belongs to the leukotriene receptor antagonist class, offering an oral alternative to inhaled corticosteroids or antihistamines for asthma and allergic rhinitis. Unlike inhaled steroids, it is taken once daily and does not require a device, but it may be less potent for severe asthma. Compared with other leukotriene antagonists such as zafirlukast, montelukast has a more favorable dosing schedule and broader regulatory approval.

Montelukast Evolugen tablets should be stored at room temperature, below 25 °C, in their original packaging to protect from moisture and light. Keep the container tightly closed and out of reach of children. Do not store in bathrooms or near heat sources, and discard any tablets that appear discolored or damaged.

Montelukast Evolugen is taken orally as a tablet. Swallow the tablet whole with water; it may be taken with or without food. For consistent blood levels, it is usually recommended to take the dose at the same time each day, preferably in the evening for asthma maintenance, unless otherwise directed by a healthcare professional.

Serious adverse events include severe allergic reactions such as angioedema, skin conditions like Stevens‑Johnson syndrome, eosinophilic granulomatosis with polyangiitis, hepatic injury, and neuropsychiatric effects including mood changes, depression, or suicidal thoughts. Patients should seek immediate medical attention if they experience swelling of the face or throat, rash, jaundice, or any sudden change in mental health.

Montelukast should be avoided in individuals with known hypersensitivity to montelukast sodium or any tablet excipients. Caution is advised for patients with severe hepatic impairment, and it is not recommended for use in children under the age approved for the specific formulation without medical supervision. Pregnant or breastfeeding women should only use it after a thorough risk‑benefit discussion with their physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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