Product image of Montelukast Generics (Montelukast) supplied by GNH India

Montelukast Generics

Active Ingredient:
Montelukast
Origin:
EU

Montelukast Generics (Montelukast)

Montelukast, the active ingredient in Montelukast Generics, is a leukotriene receptor antagonist presented as an oral tablet for oral use. It is prescribed to manage asthma and allergic rhinitis in adults and children.
GNH India supplies Montelukast Generics as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Generics [uk] Limited

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Indications & Clinical Uses

  • Montelukast is used to manage conditions that involve leukotriene‑mediated airway inflammation.
  • Asthma: improves long‑term control and reduces the frequency of bronchospasm.
  • Allergic rhinitis: relieves nasal congestion, sneezing, itching and rhinorrhea.
  • Exercise‑induced bronchoconstriction: prevents symptoms triggered by physical activity.

How It Works

  • Montelukast selectively blocks the cysteinyl leukotriene receptor CysLT1, preventing leukotriene D4 from binding. This inhibition reduces leukotriene‑induced bronchoconstriction, vascular permeability, and inflammatory cell recruitment in the airways, thereby improving respiratory function and decreasing allergic inflammation.

Side Effects

Montelukast is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Headache
  • Abdominal pain
  • Cough
  • Nausea
  • Sore throat
  • Dizziness

Serious or Rare Side Effects

  • Allergic reactions such as angioedema or anaphylaxis
  • Mood changes, including suicidal thoughts
  • Elevated liver enzymes
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis
  • Eosinophilic granulomatosis with polyangiitis
  • Chest pain or palpitations

Precautions & Warnings

  • Before initiating therapy, consider the following precautions.
  • Monitor mood changes: watch for depression or suicidal ideation.
  • Assess liver function: use cautiously in patients with hepatic impairment.
  • Avoid in known hypersensitivity: discontinue if allergic reaction occurs.
  • Review concomitant medications: check for potential drug interactions.
  • Use with caution in severe hepatic disease: dose adjustment may be required.
  • Store at below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Montelukast may interact with several medicines; awareness of interaction severity is important.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole): may increase plasma levels.
  • Phenobarbital and other enzyme inducers: may reduce effectiveness.
  • Rifampin: can lower drug concentrations.
  • Certain antidepressants (e.g., fluoxetine): may heighten neuropsychiatric risk.
  • Warfarin: potential alteration of INR.

Moderate Interactions (Monitor Closely)

  • Phenylephrine or pseudoephedrine: may diminish bronchodilatory benefit.
  • Beta‑agonists: additive bronchodilation may occur.
  • NSAIDs: possible increase in bronchospasm risk.
  • Theophylline: plasma levels may be affected.
  • Montelukast with other leukotriene modifiers: monitor for overlapping toxicity.

Frequently Asked Questions

Montelukast Generics is indicated for the maintenance treatment of asthma, relief of symptoms of allergic rhinitis, and prevention of exercise‑induced bronchoconstriction. It works by reducing airway inflammation and bronchospasm associated with leukotriene activity.

Montelukast blocks the cysteinyl leukotriene receptor CysLT1, preventing leukotriene D4 from triggering bronchoconstriction, mucus secretion, and inflammatory cell recruitment. This antagonism reduces airway narrowing and allergic inflammation, improving breathing and nasal symptoms.

The dosage of Montelukast Generics is determined by the prescribing healthcare professional based on the patient’s age, condition, and response to therapy. Patients should follow the prescriber’s instructions and not adjust the dose without medical guidance.

Safety data for Montelukast in pregnancy and lactation are limited. Healthcare providers should weigh the potential benefits against possible risks before prescribing to pregnant or nursing women. Women should discuss any concerns with their physician.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and required import documentation.

Montelukast belongs to the leukotriene receptor antagonist class, offering an oral alternative to inhaled corticosteroids and long‑acting beta‑agonists. It is particularly useful for patients with aspirin‑sensitive asthma or those who prefer a non‑inhaled option, though it may be less potent for acute symptom relief.

Montelukast Generics should be stored at temperatures below 25 °C, in the original packaging, and protected from moisture and direct sunlight. Keeping the product in a dry, cool place helps maintain its stability and potency.

Montelukast Generics is taken orally, usually once daily in the evening, with or without food. The tablet should be swallowed whole with a glass of water. Patients should follow the dosing schedule prescribed by their healthcare provider.

Serious risks include rare allergic reactions such as angioedema or anaphylaxis, neuropsychiatric events like depression or suicidal thoughts, and severe liver enzyme elevations. Patients should seek immediate medical attention if they experience any of these symptoms.

Montelukast Generics should be avoided in individuals with known hypersensitivity to montelukast or any component of the formulation. Caution is also advised for patients with severe hepatic impairment, and it is not recommended for acute asthma attacks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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