Product image of Montelukast Glenmark Pharmaceuticals Europe (Montelukast Sodium) supplied by GNH India

Montelukast Glenmark Pharmaceuticals Europe

Active Ingredient:
Montelukast Sodium
Origin:
EU

Montelukast Glenmark Pharmaceuticals Europe (Montelukast Sodium)

Montelukast, the active ingredient in Montelukast Glenmark Pharmaceuticals Europe, is a leukotriene receptor antagonist presented as an oral tablet for oral use. It treats asthma, exercise‑induced bronchoconstriction and allergic rhinitis in adults and children.

GNH India supplies Montelukast Glenmark Pharmaceuticals Europe as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Glenmark Pharmaceuticals Europe Limited

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Indications & Clinical Uses

Montelukast is indicated for conditions involving leukotriene‑mediated airway inflammation.

  • Asthma: improves long‑term control of symptoms and reduces exacerbations in patients requiring maintenance therapy.
  • Exercise‑induced bronchoconstriction: prevents narrowing of airways triggered by physical activity.
  • Allergic rhinitis: alleviates nasal congestion, sneezing and itchy eyes associated with seasonal or perennial allergic rhinitis.

How It Works

  • Montelukast selectively blocks the cysteinyl leukotriene receptor CysLT1 on airway smooth‑muscle cells, mast cells and eosinophils. By antagonising this receptor, it prevents leukotriene‑induced bronchoconstriction, vascular permeability and inflammatory cell recruitment, thereby reducing airway edema and hyper‑responsiveness associated with asthma and allergic rhinitis.

Side Effects

Montelukast may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Headache
  • Abdominal pain
  • Cough
  • Sore throat
  • Nausea
  • Dizziness

Serious or Rare Side Effects

  • Allergic reactions such as angioedema or anaphylaxis
  • Mood changes including depression or suicidal thoughts
  • Elevated liver enzymes or hepatitis
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis
  • Eosinophilic granulomatosis with polyangiitis (rare)

Precautions & Warnings

Before initiating therapy, consider the following precautions.

  • Pregnancy: safety not established; use only if potential benefit justifies the risk.
  • Breastfeeding: unknown safety; weigh maternal benefit against potential infant exposure.
  • Concomitant strong CYP3A4 inducers (e.g., rifampin, carbamazepine): may reduce drug exposure.
  • Renal or hepatic impairment: monitor clinical response and adjust if necessary.
  • Known hypersensitivity to montelukast or any excipients: avoid use.
  • Store at ambient temperature below 25°C: keep in the original container, protect from moisture.

Avoid Interactions

Montelukast can interact with several medicines; assess the clinical relevance before co‑administration.

Major Interactions (Avoid)

  • Phenobarbital, rifampin, carbamazepine: may markedly lower montelukast plasma concentrations.
  • Strong CYP3A4 inducers: may diminish therapeutic effect.

Moderate Interactions (Monitor Closely)

  • Warfarin: potential increase in INR; monitor coagulation parameters.
  • Theophylline: additive central nervous system effects may occur.
  • Fluconazole: may raise montelukast levels; observe for enhanced adverse reactions.

Frequently Asked Questions

Montelukast is prescribed as a maintenance therapy for asthma, to prevent exercise‑induced bronchoconstriction, and to relieve symptoms of allergic rhinitis such as nasal congestion, sneezing and itchy eyes.

Montelukast blocks the cysteinyl leukotriene receptor CysLT1, preventing leukotrienes from binding and triggering bronchoconstriction, airway inflammation, and mucus production, which helps keep the airways open and reduces allergic inflammation.

The appropriate dose of Montelukast is determined by a qualified prescriber based on the patient’s age, indication and clinical response. Patients should follow the dosing instructions provided on the prescription label.

Safety data for Montelukast in pregnancy are limited, and the drug is not classified in a specific pregnancy category. It should be used only if the potential benefit justifies any possible risk. Information on breastfeeding is also insufficient, so a risk‑benefit assessment is required.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Montelukast belongs to the leukotriene receptor antagonist class, offering an oral alternative to inhaled corticosteroids or long‑acting beta‑agonists. It is particularly useful for patients who prefer a tablet form or have exercise‑induced symptoms, though inhaled steroids remain the first‑line option for many severe asthma cases.

Montelukast tablets should be stored at ambient temperature below 25 °C, protected from moisture and light. Keep the product in its original blister pack until use and avoid storing in humid environments such as bathrooms.

Montelukast is taken orally, usually once daily in the evening, with or without food. The tablet should be swallowed whole with a glass of water; it is not intended for chewing or crushing.

Serious adverse events include severe allergic reactions (e.g., angioedema, anaphylaxis), mood disturbances such as depression or suicidal thoughts, and rare skin conditions like Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience any of these symptoms.

Montelukast is contraindicated in individuals with known hypersensitivity to the drug or any of its excipients. Caution is also advised for patients with a history of severe psychiatric disorders, liver disease, or those taking strong CYP3A4‑inducing medications.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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