Product image of Montelukast Krka (Montelukast) supplied by GNH India

Montelukast Krka

Active Ingredient:
Montelukast
Origin:
EU

Montelukast Krka (Montelukast)

Montelukast, the active ingredient in Montelukast Krka, is a leukotriene receptor antagonist presented as an oral tablet for oral use. It is employed to prevent asthma symptoms and to relieve allergic rhinitis in adults and children, and is prescribed by healthcare professionals.

GNH India supplies Montelukast Krka as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and regulatory requirements across EU markets.

Manufacturer / TM Owner

Krka, D.D., Novo Mesto

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Indications & Clinical Uses

  • Montelukast is a leukotriene receptor antagonist used in the management of respiratory allergic conditions.
  • Asthma prophylaxis: reduces the frequency of asthma attacks and improves control in patients with persistent asthma.
  • Allergic rhinitis: alleviates nasal congestion, sneezing and itching associated with seasonal or perennial allergic rhinitis.
  • Exercise‑induced bronchoconstriction: prevents bronchospasm triggered by physical activity in susceptible individuals.

How It Works

  • Montelukast selectively blocks the cysteinyl leukotriene receptor CysLT1, preventing leukotriene D4 and related mediators from binding. This inhibition reduces bronchoconstriction, vascular permeability, mucus secretion, and inflammatory cell recruitment in the airways, thereby improving respiratory function and decreasing allergic inflammation.

Side Effects

Montelukast is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Headache: mild to moderate pain often resolving without intervention.
  • Abdominal pain: discomfort in the stomach region, usually transient.
  • Nausea: feeling of queasiness that may or may not lead to vomiting.
  • Cough: occasional irritation of the throat.
  • Dizziness: brief episodes of light‑headedness.
  • Fatigue: feeling unusually tired.

Serious or Rare Side Effects

  • Angioedema: swelling of the face, lips, tongue, or throat requiring urgent care.
  • Stevens‑Johnson syndrome: severe skin reaction with blistering and mucosal involvement.
  • Eosinophilic granulomatosis with polyangiitis: rare vasculitis affecting multiple organs.
  • Neuropsychiatric events: mood changes, depression, or suicidal thoughts.
  • Hepatic injury: signs of liver dysfunction such as jaundice.
  • Anaphylaxis: immediate hypersensitivity reaction with respiratory distress.

Precautions & Warnings

  • Before prescribing Montelukast, clinicians should consider several safety aspects.
  • Assess asthma control before initiating: ensure the patient is on appropriate inhaled therapy.
  • Monitor for neuropsychiatric events: watch for mood changes, depression, or suicidal thoughts.
  • Use caution in patients with hepatic impairment: evaluate liver function and adjust if needed.
  • Avoid use in patients with known hypersensitivity to montelukast or excipients.
  • Pregnancy and lactation: discuss risk/benefit with the prescriber before use.
  • Store at room temperature below 25°C: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Montelukast may interact with several medicines; awareness helps maintain efficacy and safety.

Major Interactions (Avoid)

  • Ritonavir: can increase montelukast plasma concentrations, raising risk of adverse effects.
  • Phenobarbital, phenytoin, carbamazepine: strong enzyme inducers that may reduce montelukast effectiveness.
  • Fluconazole: a CYP2C9 inhibitor that may elevate montelukast levels.
  • Strong CYP2C9 inhibitors (e.g., fluconazole): avoid concomitant use when possible.

Moderate Interactions (Monitor Closely)

  • Warfarin: potential alteration of INR; monitor coagulation parameters.
  • Theophylline: additive bronchodilator effect; observe clinical response.
  • Beta‑agonists: no significant pharmacokinetic interaction, but monitor overall asthma control.

Frequently Asked Questions

Montelukast Krka is a prescription oral tablet that belongs to the leukotriene receptor antagonist class. It is indicated for the prophylaxis and chronic treatment of asthma, for relief of symptoms associated with allergic rhinitis, and for prevention of exercise‑induced bronchoconstriction in patients with documented sensitivity.

Montelukast selectively blocks the cysteinyl leukotriene receptor CysLT1 on airway smooth muscle and inflammatory cells. By preventing leukotriene D4 and related mediators from binding, it reduces bronchoconstriction, mucus production, vascular leakage, and recruitment of eosinophils, thereby improving airway patency and decreasing allergic inflammation.

The dosage of Montelukast Krka is determined by the prescribing clinician based on the patient’s age, weight, indication, and overall treatment plan. Healthcare professionals select the appropriate strength and frequency, and patients should follow the prescriber’s instructions without deviation.

Safety data for Montelukast in pregnancy and lactation are limited. The medication should only be used if the potential benefit justifies any possible risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss individual risks and benefits with their healthcare provider.

To place an order, submit an enquiry on the Montelukast Krka product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any temperature requirements), and the necessary import documentation.

Montelukast and inhaled corticosteroids (ICS) target different pathways in asthma management. Montelukast blocks leukotriene‑mediated inflammation, while ICS suppress a broader range of inflammatory mediators. Montelukast is often used as an add‑on therapy for patients whose asthma is not fully controlled with ICS alone, but it does not replace the anti‑inflammatory potency of high‑dose corticosteroids.

Montelukast Krka tablets should be stored at room temperature below 25 °C, protected from moisture, heat, and direct sunlight. Keep the product in its original blister pack or container until use. Do not store in bathrooms or near kitchen appliances that generate steam or high heat.

Montelukast Krka is taken orally, usually once daily in the evening, with or without food, as directed by the prescriber. The tablet should be swallowed whole with a glass of water. For pediatric patients, the appropriate pediatric formulation and dose are selected by the healthcare professional.

Serious adverse events, though rare, include angioedema, severe skin reactions such as Stevens‑Johnson syndrome, eosinophilic granulomatosis with polyangiitis, and neuropsychiatric effects like depression or suicidal thoughts. Patients should seek immediate medical attention if they experience swelling of the face or throat, rash with blistering, persistent mood changes, or any signs of an allergic reaction.

Montelukast Krka is contraindicated in individuals with known hypersensitivity to montelukast or any of its excipients. Caution is also advised for patients with severe hepatic impairment, and it should be avoided in patients who have experienced serious neuropsychiatric reactions to the drug in the past.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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