Product image of Montelukast Medreg (Montelukast) supplied by GNH India

Montelukast Medreg

Active Ingredient:
Montelukast
Origin:
EU

Montelukast Medreg (Montelukast)

Montelukast, the active ingredient in Montelukast Medreg, is a leukotriene receptor antagonist presented as a tablet for oral use. It treats asthma, allergic rhinitis, and exercise‑induced bronchoconstriction in adults and children. It is commonly incorporated into long‑term management plans to reduce symptom frequency and improve quality of life.

GNH India supplies Montelukast Medreg as a licensed, GDP‑compliant international pharmaceutical supplier, adhering to EU quality standards and providing the product to hospitals, pharmacies and clinics worldwide through regulated distribution channels globally.

Manufacturer / TM Owner

Medreg S.R.O.

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Indications & Clinical Uses

  • Montelukast is a leukotriene receptor antagonist used to manage conditions driven by leukotriene‑mediated inflammation.
  • Asthma: improves control of persistent asthma and reduces exacerbations.
  • Allergic rhinitis: alleviates nasal congestion, sneezing and itching associated with seasonal or perennial allergic rhinitis.
  • Exercise‑induced bronchoconstriction: prevents airway narrowing triggered by physical activity.

How It Works

  • Montelukast selectively blocks the cysteinyl leukotriene receptor CysLT1 on airway smooth‑muscle cells, mast cells and eosinophils. By antagonizing this receptor, it prevents leukotrienes D4, E4 and F4 from binding, thereby inhibiting the cascade that leads to bronchoconstriction, mucus secretion, vascular permeability and inflammatory cell recruitment. This results in reduced airway inflammation and improved respiratory function. The effect is dose‑dependent and contributes to long‑term control of airway hyper‑responsiveness.

Side Effects

Montelukast may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Headache
  • Abdominal pain
  • Cough
  • Nausea

Serious or Rare Side Effects

  • Allergic reactions such as rash, urticaria or angioedema
  • Neuropsychiatric events including agitation, depression or suicidal thoughts
  • Angioedema affecting the face, lips or throat
  • Stevens‑Johnson syndrome or other severe skin reactions

Precautions & Warnings

  • When prescribing Montelukast, clinicians should consider several precautionary measures to ensure safe use.
  • Assess hepatic function: monitor liver enzymes in patients with liver disease.
  • Monitor neuropsychiatric symptoms: watch for mood changes, depression or suicidal ideation.
  • Avoid in known hypersensitivity: discontinue if rash, urticaria or angioedema occurs.
  • Use caution during pregnancy: limited data, weigh benefits versus potential risks.
  • Store at ambient temperature: keep below 25 °C in original packaging, protect from moisture.

Avoid Interactions

Montelukast can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Phenobarbital: enzyme induction reduces Montelukast plasma levels.
  • Rifampin: strong inducer of hepatic metabolism, decreasing exposure.
  • Ketoconazole: CYP3A4 inhibition may increase Montelukast concentrations.

Moderate Interactions (Monitor Closely)

  • Warfarin: possible increase in INR, monitor coagulation.
  • Beta‑agonists: additive bronchodilatory effect may enhance symptom control.
  • ACE inhibitors: rare reports of bronchospasm, observe respiratory status.

Frequently Asked Questions

Montelukast Medreg is prescribed for the management of persistent asthma, allergic rhinitis (both seasonal and perennial), and exercise‑induced bronchoconstriction. In each of these conditions, the drug helps to reduce airway inflammation, lessen symptom frequency, and improve overall respiratory function as part of a long‑term treatment plan.

Montelukast works by selectively blocking the cysteinyl leukotriene receptor CysLT1 on cells in the respiratory tract. By preventing leukotrienes D4, E4 and F4 from binding, it stops the inflammatory cascade that causes bronchoconstriction, mucus production, and vascular leakage, thereby reducing airway swelling and improving breathing.

The dose of Montelukast Medreg is individualized by the prescribing healthcare professional. Factors such as the patient’s age, weight, severity of the respiratory condition, and response to therapy are considered. The prescriber will select the appropriate strength and dosing schedule based on current clinical guidelines and the patient’s specific needs.

Safety data for Montelukast during pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. Women who are pregnant, planning pregnancy, or breastfeeding should discuss potential risks and benefits with their physician before starting or continuing therapy.

To place an order, visit the product page on gnhindia.com and submit an enquiry with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials. After confirmation, the sales team provides pricing, availability, shipping details (including any cold‑chain requirements) and assists with import documentation.

Montelukast and inhaled corticosteroids (ICS) target different aspects of asthma pathology. Montelukast blocks leukotriene‑mediated inflammation, while ICS reduce overall airway inflammation through glucocorticoid receptors. In many treatment guidelines, Montelukast is used as an add‑on therapy or alternative for patients who cannot tolerate steroids, but it is generally not a substitute for high‑dose ICS in severe cases.

Montelukast Medreg should be stored at ambient temperature, preferably below 25 °C (77 °F). Keep the tablets in their original blister pack or container, protect them from moisture and direct sunlight, and store them out of reach of children. Do not refrigerate or freeze the product.

Montelukast Medreg is taken orally, usually as a whole tablet with or without food. The exact timing (e.g., morning or evening) and whether it should be taken with a meal are determined by the prescribing clinician based on the individual’s therapeutic plan and convenience.

Serious risks, although rare, include severe allergic reactions such as angioedema, skin disorders like Stevens‑Johnson syndrome, and neuropsychiatric events that may manifest as agitation, depression, or suicidal thoughts. Patients should seek immediate medical attention if they experience any signs of an allergic reaction or significant mood changes.

Montelukast Medreg should be avoided in individuals with a known hypersensitivity to Montelukast or any component of the formulation. Caution is also advised for patients with severe liver impairment, and it should be used only under medical supervision in pregnant or nursing women due to limited safety data.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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