Product image of Montelukast Pharmathen (Montelukast) supplied by GNH India

Montelukast Pharmathen

Active Ingredient:
Montelukast
Origin:
EU

Montelukast Pharmathen (Montelukast)

Montelukast, the active ingredient in Montelukast Pharmathen, is a leukotriene receptor antagonist presented as an oral tablet for oral use. It is indicated for the management of asthma, allergic rhinitis and exercise‑induced bronchoconstriction in both adult and pediatric patients through daily therapy and provides symptom control.

GNH India supplies Montelukast Pharmathen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with a focus on quality assurance and regulatory compliance. The product meets EU market standards for safety and efficacy.

Manufacturer / TM Owner

Pharmathen S.A.

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Indications & Clinical Uses

  • Montelukast acts on the leukotriene pathway to reduce airway inflammation and bronchoconstriction.
  • Asthma: improves control of persistent asthma and reduces exacerbations.
  • Allergic rhinitis: alleviates nasal congestion, sneezing and itchy eyes associated with seasonal allergies.
  • Exercise‑induced bronchoconstriction: prevents narrowing of airways triggered by physical activity.

How It Works

  • Montelukast selectively blocks the cysteinyl leukotriene receptor CysLT1 on airway smooth‑muscle cells, mast cells and eosinophils. By antagonizing this receptor, it prevents leukotriene‑mediated bronchoconstriction, vascular permeability and inflammatory cell recruitment, thereby reducing airway edema and hyper‑responsiveness associated with asthma and allergic rhinitis. The inhibition is competitive and reversible, allowing normal leukotriene signaling to resume when the drug concentration falls, and contributes to long‑term control of airway tone.

Side Effects

Montelukast may be associated with a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Headache: mild to moderate head discomfort.
  • Abdominal pain: transient stomach discomfort.
  • Cough: occasional dry cough.
  • Dizziness: brief episodes of light‑headedness.

Serious or Rare Side Effects

  • Neuropsychiatric events: agitation, depression, suicidal thoughts.
  • Allergic reactions: rash, angioedema, anaphylaxis.

Precautions & Warnings

  • When prescribing Montelukast, consider the following precautions.
  • Assess asthma control before initiating therapy: ensure patient is on appropriate inhaled controller.
  • Monitor for neuropsychiatric symptoms: report mood changes or suicidal ideation.
  • Use caution in patients with hepatic impairment: adjust if necessary.
  • Avoid use in patients with known hypersensitivity to montelukast or excipients.
  • Pregnancy and lactation: discuss risk‑benefit with healthcare provider.
  • Store at ambient temperature below 25°C: keep in original container, protect from moisture and light.

Avoid Interactions

Montelukast may interact with other medicines; review the following.

Major Interactions (Avoid)

  • Phenobarbital: may reduce plasma concentrations of montelukast.
  • Rifampin: induces metabolism, decreasing efficacy.
  • Strong CYP3A4 inhibitors: may increase exposure, raising risk of side effects.

Moderate Interactions (Monitor Closely)

  • Warfarin: possible alteration of anticoagulant effect, monitor INR.
  • Theophylline: additive bronchodilator effect, monitor for tachycardia.
  • Beta‑agonists: no direct interaction but combined therapy may enhance bronchodilation.

Frequently Asked Questions

Montelukast Pharmathen is used to manage persistent asthma, relieve symptoms of allergic rhinitis, and prevent exercise‑induced bronchoconstriction. It works by targeting leukotriene‑mediated pathways that contribute to airway narrowing and inflammation, providing long‑term control of respiratory symptoms.

Montelukast selectively blocks the cysteinyl leukotriene receptor CysLT1 on airway cells. By antagonizing this receptor, it stops leukotrienes from causing bronchoconstriction, mucus production, and inflammatory cell recruitment, thereby reducing airway swelling and hyper‑responsiveness.

The dose of Montelukast Pharmathen is determined by the prescribing clinician based on the patient’s age, condition severity, and response to therapy. Healthcare providers follow approved dosing guidelines, and patients should follow the prescriber’s instructions without deviation.

Safety data for Montelukast in pregnancy and lactation are limited. The prescriber should weigh potential benefits against possible risks and discuss these considerations with the patient. Breastfeeding mothers should also consult their healthcare professional before using the medication.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials. The team then replies with pricing, availability, shipping details and any required import documentation.

The primary alternative for asthma control is inhaled corticosteroids, which reduce airway inflammation directly. Montelukast, as a leukotriene receptor antagonist, offers an oral option that targets a different inflammatory pathway and can be used as add‑on therapy or when inhaled steroids are not tolerated.

Store Montelukast Pharmathen at ambient temperature below 25 °C, in its original packaging, protected from moisture and light. Keep the product out of reach of children and avoid exposing it to extreme heat or humidity.

Montelukast Pharmathen is taken orally, usually as a single tablet per day. It can be swallowed with or without food, according to the prescriber’s instructions. Consistency in timing helps maintain steady drug levels.

Serious risks include neuropsychiatric events such as agitation, depression, or suicidal thoughts, and severe allergic reactions like rash, angioedema, or anaphylaxis. Patients should seek immediate medical attention if they experience mood changes, thoughts of self‑harm, or signs of an allergic reaction.

Montelukast should be avoided in individuals with known hypersensitivity to montelukast or any of its excipients. Caution is advised for patients with severe hepatic impairment, and it is not recommended for use in children under the age approved for the specific formulation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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