Product image of Montelukast Pharmathen S.A. (Montelukast) supplied by GNH India

Montelukast Pharmathen S.A.

Active Ingredient:
Montelukast
Origin:
EU

Montelukast Pharmathen S.A. (Montelukast)

Montelukast, the active ingredient in Montelukast Pharmathen S.A., is a leukotriene receptor antagonist presented as an oral tablet for oral use. It is employed to manage chronic asthma and allergic rhinitis, helping to reduce airway inflammation and nasal symptoms in patients of all ages. The medication works by blocking specific leukotriene receptors that contribute to bronchoconstriction and allergic responses.

GNH India supplies Montelukast Pharmathen S.A. as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Pharmathen S.A.

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Indications & Clinical Uses

Montelukast acts on the leukotriene pathway to control inflammatory airway diseases.

  • Asthma: reduces frequency of exacerbations and improves lung function in persistent asthma.
  • Allergic rhinitis: alleviates nasal congestion, sneezing and itchy eyes associated with seasonal allergies.
  • Exercise‑induced bronchoconstriction: prevents airway narrowing triggered by physical activity.

How It Works

  • Montelukast selectively antagonizes the cysteinyl leukotriene receptor CysLT1, inhibiting the actions of leukotrienes D4, E4 and related mediators. By blocking this receptor, it prevents leukotriene‑induced bronchoconstriction, vascular permeability, mucus secretion and inflammatory cell recruitment, thereby reducing airway inflammation and allergic symptoms.

Side Effects

Montelukast is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Abdominal pain: occasional discomfort.
  • Nausea: transient gastrointestinal upset.
  • Dizziness: occasional light‑headedness.

Serious or Rare Side Effects

  • Allergic reactions: rash, angioedema, or anaphylaxis.
  • Mood changes: depression, suicidal thoughts, or behavioral disturbances.
  • Hepatic enzyme elevation: signs of liver dysfunction.
  • Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.

Precautions & Warnings

Before prescribing Montelukast, clinicians should consider several safety aspects.

  • Assess asthma control: ensure baseline therapy is optimized.
  • Monitor mood: watch for depression or suicidal ideation.
  • Use with caution in hepatic impairment: dose adjustment may be needed.
  • Avoid in patients with known hypersensitivity to montelukast or excipients.
  • Store at below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Montelukast may interact with other medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir): may increase montelukast plasma levels.
  • Strong CYP inducers (e.g., rifampicin, phenobarbital): may reduce therapeutic effect.
  • Concurrent use with other leukotriene modifiers: risk of additive adverse effects.

Moderate Interactions (Monitor Closely)

  • Warfarin: may enhance anticoagulant effect, requiring INR monitoring.
  • Beta‑agonists: possible additive bronchodilator effect, monitor respiratory status.

Frequently Asked Questions

Montelukast Pharmathen S.A. is indicated for the long‑term management of asthma, relief of symptoms associated with allergic rhinitis, and prevention of exercise‑induced bronchoconstriction. It helps control airway inflammation and reduces the frequency of asthma attacks and nasal allergy symptoms.

Montelukast works by selectively blocking the cysteinyl leukotriene receptor CysLT1. This inhibition prevents leukotrienes—potent inflammatory mediators—from causing bronchoconstriction, mucus production, and vascular leakage, thereby reducing airway narrowing and allergic inflammation.

The appropriate dose of Montelukast is determined by the prescribing healthcare professional based on the patient’s age, condition, and response to therapy. Dosage recommendations are provided in the product labeling and should be followed exactly as instructed by the prescriber.

Safety data for Montelukast in pregnancy and lactation are limited. Healthcare providers should weigh the potential benefits against any possible risks before prescribing it to pregnant or nursing women. Women should discuss their specific situation with a qualified medical professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.

Montelukast belongs to the leukotriene receptor antagonist class, offering an oral alternative to inhaled corticosteroids or long‑acting beta‑agonists. It is particularly useful for patients with aspirin‑sensitive asthma or those who prefer a once‑daily oral regimen, though it may be less potent than inhaled steroids for severe disease.

Montelukast tablets should be stored at temperatures below 25 °C, in the original packaging, and protected from moisture and direct sunlight. Maintaining these conditions helps preserve the product’s stability and potency throughout its shelf life.

Montelukast is taken orally, usually once daily in the evening, with or without food. The tablet should be swallowed whole with a glass of water. Patients should follow the dosing schedule prescribed by their healthcare provider.

Serious risks include allergic reactions such as rash, angioedema, or anaphylaxis, as well as neuropsychiatric events like depression, suicidal thoughts, and behavioral changes. Liver enzyme elevations and severe skin reactions (e.g., Stevens‑Johnson syndrome) have also been reported and require immediate medical attention.

Montelukast should not be used by individuals with a known hypersensitivity to the drug or any of its excipients. It is also contraindicated in patients who have experienced severe allergic reactions to leukotriene‑modifying agents. Clinicians should evaluate each patient’s medical history before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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