Product image of Montelukast Ratiopharm (Montelukast) supplied by GNH India

Montelukast Ratiopharm

Active Ingredient:
Montelukast
Origin:
EU

Montelukast Ratiopharm (Montelukast)

Montelukast, the active ingredient in Montelukast Ratiopharm, is a leukotriene receptor antagonist presented as a tablet for oral use. It treats asthma and allergic rhinitis in adults and children by blocking cysteinyl leukotriene receptors that cause airway inflammation and nasal congestion.

GNH India supplies Montelukast Ratiopharm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with established logistics networks and regulatory expertise to ensure reliable delivery across multiple regions. The company adheres to stringent quality standards and provides comprehensive documentation for import and compliance.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

Montelukast is a leukotriene receptor antagonist used to manage conditions driven by cysteinyl leukotriene activity.

  • Asthma: improves control of persistent asthma and reduces frequency of exacerbations.
  • Allergic rhinitis: alleviates nasal congestion, sneezing and itchy eyes associated with seasonal or perennial allergic rhinitis.
  • Exercise‑induced bronchoconstriction: prevents airway narrowing that occurs after vigorous physical activity.

How It Works

  • Montelukast selectively binds to the cysteinyl leukotriene receptor CysLT1 on airway smooth‑muscle cells, mast cells and eosinophils. By blocking this receptor, it prevents leukotrienes D4, E4 and related cysteinyl leukotrienes from triggering bronchoconstriction, mucus secretion, vascular permeability and inflammatory cell recruitment, thereby reducing airway inflammation and nasal mucosal edema.

Side Effects

Montelukast may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Headache
  • Abdominal pain
  • Cough
  • Nausea

Serious or Rare Side Effects

  • Allergic reactions such as rash, angioedema or anaphylaxis
  • Neuropsychiatric events including depression, anxiety or suicidal thoughts
  • Hepatic enzyme elevations or hepatitis
  • Severe skin reactions such as Stevens‑Johnson syndrome or toxic epidermal necrolysis

Precautions & Warnings

When prescribing Montelukast, clinicians should consider several safety precautions.

  • Assess asthma control before initiating: ensure patient is on appropriate inhaled therapy.
  • Monitor for neuropsychiatric events: watch for mood changes, depression or suicidal ideation.
  • Use caution in hepatic impairment: evaluate liver function and adjust if necessary.
  • Avoid in patients with known hypersensitivity to montelukast or any tablet excipients.
  • Store at room temperature: keep in the original packaging, protect from moisture and excessive heat.

Avoid Interactions

Montelukast can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Phenobarbital: enzyme induction may lower montelukast plasma concentrations.
  • Rifampin: strong inducer of CYP enzymes can reduce therapeutic effect.
  • Ketoconazole: potent CYP3A4 inhibition may increase montelukast levels.

Moderate Interactions (Monitor Closely)

  • Warfarin: montelukast may potentiate anticoagulant effect, requiring INR monitoring.
  • Theophylline: concurrent use can increase the risk of theophylline‑related side effects.
  • Short‑acting β2‑agonists: additive bronchodilation may occur, requiring clinical observation.

Frequently Asked Questions

Montelukast Ratiopharm is prescribed to manage persistent asthma, relieve symptoms of allergic rhinitis, and prevent exercise‑induced bronchoconstriction. By targeting leukotriene pathways, it helps reduce airway inflammation, bronchospasm and nasal congestion in both adult and pediatric patients.

Montelukast works as a selective antagonist of the cysteinyl leukotriene receptor CysLT1. Blocking this receptor stops leukotrienes D4, E4 and related molecules from causing bronchoconstriction, mucus production, vascular leakage and inflammatory cell recruitment, which together contribute to asthma and allergic rhinitis symptoms.

The appropriate dose of Montelukast Ratiopharm is determined by the prescribing healthcare professional based on the patient’s age, condition and response to therapy. Dosage regimens may differ for asthma, allergic rhinitis or exercise‑induced bronchoconstriction, and should always follow the prescriber’s instructions.

Safety data for Montelukast in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any potential risk to the fetus or infant. Women who are pregnant, planning pregnancy or breastfeeding should discuss the risks and alternatives with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Montelukast belongs to the leukotriene receptor antagonist class, offering an oral alternative to inhaled corticosteroids or long‑acting β2‑agonists. While it is effective for certain patients, especially those with allergic components, it may be less potent than inhaled steroids for severe asthma. It can be used as add‑on therapy or when inhaler use is problematic.

Montelukast Ratiopharm tablets should be stored at room temperature, below 25 °C, in the original blister or container. Protect them from moisture, direct sunlight and excessive heat to maintain potency throughout the shelf life.

Montelukast is taken orally, usually as a single tablet swallowed whole with or without food. The exact timing (e.g., in the evening) may be advised by the prescriber, and the tablet should not be chewed, crushed or split unless specifically instructed.

Serious risks include severe allergic reactions such as rash, angioedema or anaphylaxis, neuropsychiatric events like depression, anxiety or suicidal thoughts, and rare hepatic injury or severe skin disorders such as Stevens‑Johnson syndrome. Patients should seek immediate medical attention if any of these symptoms appear.

Montelukast should be avoided in individuals with known hypersensitivity to the drug or any of its excipients. Caution is also advised for patients with severe hepatic impairment, and it is not recommended as a sole therapy for acute asthma attacks. Clinical judgment is required for each patient.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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