Product image of Montelukast Ratiopharm (Montelukast Sodium) supplied by GNH India

Montelukast Ratiopharm

Active Ingredient:
Montelukast Sodium
Origin:
EU

Montelukast Ratiopharm (Montelukast Sodium)

Montelukast, the active ingredient in Montelukast Ratiopharm, is a leukotriene receptor antagonist presented as a tablet for buccal, cutaneous, dental, nasal use. It treats asthma, allergic rhinitis and exercise‑induced bronchoconstriction in adults and children.

GNH India supplies Montelukast Ratiopharm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ratiopharm Gmbh

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Indications & Clinical Uses

Montelukast Ratiopharm is indicated for conditions involving leukotriene‑mediated inflammation.

  • Asthma (maintenance therapy): reduces frequency of bronchospasm and improves overall control.
  • Allergic rhinitis: alleviates nasal congestion, sneezing and itchy eyes.
  • Exercise‑induced bronchoconstriction: prevents airway narrowing triggered by physical activity.

How It Works

  • Montelukast selectively blocks the cysteinyl leukotriene receptor CysLT1, preventing leukotriene D4 and related mediators from binding. By inhibiting this pathway, it reduces bronchial smooth‑muscle contraction, vascular permeability, and mucus secretion, thereby mitigating airway inflammation and hyper‑responsiveness associated with asthma and allergic disorders.

Side Effects

Montelukast may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Headache: mild to moderate pain in the head.
  • Upper respiratory tract infection: symptoms such as sore throat or nasal congestion.
  • Abdominal pain: discomfort or cramps in the stomach area.
  • Cough: occasional dry or productive cough.

Serious or Rare Side Effects

  • Allergic reactions: rash, itching, swelling, or anaphylaxis.
  • Neuropsychiatric events: agitation, depression, or suicidal thoughts.
  • Hepatic dysfunction: elevated liver enzymes or hepatitis.

Precautions & Warnings

Before prescribing Montelukast, clinicians should consider several safety aspects.

  • Assess asthma control: ensure patient’s asthma is stable before initiating therapy.
  • Monitor for neuropsychiatric symptoms: watch for mood changes or suicidal ideation.
  • Evaluate liver function: consider baseline tests in patients with hepatic disease.
  • Use caution in children: adjust monitoring based on age and response.
  • Review concomitant medications: check for potential interactions affecting leukotriene pathways.
  • Store at ambient temperature: keep below 25°C in the original container, protect from moisture.

Avoid Interactions

Montelukast can interact with other medicines, requiring attention to the level of risk.

Major Interactions (Avoid)

  • Phenobarbital: may reduce montelukast plasma concentrations.
  • Rifampin: induces metabolism leading to decreased efficacy.

Moderate Interactions (Monitor Closely)

  • Antidepressants (e.g., fluoxetine): may increase risk of neuropsychiatric effects.
  • Beta‑agonists: additive bronchodilation may require dose adjustment.
  • Warfarin: occasional reports of altered INR, monitor coagulation.

Frequently Asked Questions

Montelukast Ratiopharm is prescribed for maintenance therapy of asthma, for relief of symptoms associated with allergic rhinitis, and to prevent exercise‑induced bronchoconstriction. These indications reflect its role in blocking leukotriene‑mediated airway inflammation.

Montelukast acts as a selective antagonist of the cysteinyl leukotriene receptor CysLT1. By blocking this receptor, it prevents leukotriene D4 and related mediators from triggering bronchial smooth‑muscle contraction, mucus production, and vascular leakage, thereby reducing airway inflammation and hyper‑responsiveness.

The appropriate dose of Montelukast is determined by the prescribing healthcare professional based on the patient’s age, weight, and specific indication. Dosage regimens may differ for asthma maintenance, allergic rhinitis, or exercise‑induced bronchoconstriction, and should always follow the prescriber’s instructions.

Safety data for Montelukast in pregnancy and lactation are limited. Healthcare providers should weigh potential benefits against possible risks and consider alternative therapies when appropriate. Women who are pregnant, planning pregnancy, or breastfeeding should discuss use with their physician.

To place an order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Montelukast belongs to the leukotriene receptor antagonist class, offering an oral alternative to inhaled corticosteroids and long‑acting beta‑agonists. It is particularly useful for patients with aspirin‑exacerbated respiratory disease or those who need an adjunct to inhaled therapy, though it may be less potent for acute bronchospasm relief.

Montelukast Ratiopharm tablets should be stored at ambient temperature, preferably below 25 °C. Keep them in the original packaging, protect from moisture and direct sunlight, and ensure the container is tightly closed to maintain product stability.

Montelukast is taken orally, usually as a single tablet once daily in the evening. The tablet can be swallowed whole with water. For patients with swallowing difficulties, the tablet may be chewed or dispersed in a small amount of soft food, following the prescriber’s guidance.

Serious adverse events include allergic reactions such as rash, swelling, or anaphylaxis, and neuropsychiatric effects like agitation, depression, or suicidal thoughts. Patients should seek immediate medical attention if they experience any signs of severe allergy or significant mood changes.

Montelukast is contraindicated in individuals with known hypersensitivity to the active ingredient or any excipients in the formulation. Caution is advised for patients with severe hepatic impairment, active psychiatric disorders, or those taking medications that may significantly alter its metabolism.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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