Product image of Montelukast Ratiopharm (Montelukast Sodium) supplied by GNH India

Montelukast Ratiopharm

Active Ingredient:
Montelukast Sodium
Origin:
EU

Montelukast Ratiopharm (Montelukast Sodium)

Montelukast, the active ingredient in Montelukast Ratiopharm, is a leukotriene receptor antagonist presented as an oral tablet for systemic use. It is indicated for the management of asthma, exercise‑induced bronchoconstriction, and allergic rhinitis in adults and children.

GNH India supplies Montelukast Ratiopharm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for global distribution. Our supply chain ensures timely delivery and product integrity across multiple regions.

Manufacturer / TM Owner

Ratiopharm Gmbh

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Indications & Clinical Uses

Montelukast acts on the leukotriene pathway to control airway inflammation and bronchoconstriction.

  • Asthma: improves long‑term control and reduces the frequency of exacerbations.
  • Exercise‑induced bronchoconstriction: prevents airway narrowing during physical activity.
  • Allergic rhinitis: alleviates nasal congestion, sneezing and itchy eyes.

How It Works

  • Montelukast selectively blocks the cysteinyl leukotriene receptor CysLT1, preventing leukotrienes D4, C4 and E4 from binding. By inhibiting this receptor, the drug reduces leukotriene‑mediated bronchoconstriction, vascular permeability, and eosinophilic inflammation in the respiratory tract, leading to improved airway patency and decreased allergic inflammation.

Side Effects

Montelukast may be associated with a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Headache: mild to moderate pain often reported.
  • Abdominal pain: discomfort or cramps in the stomach area.
  • Cough: occasional dry cough.
  • Nausea: feeling of queasiness.
  • Diarrhea: loose stools.
  • Fatigue: general tiredness.

Serious or Rare Side Effects

  • Allergic reactions: rash, urticaria, or angioedema.
  • Neuropsychiatric events: mood changes, agitation, or suicidal thoughts.
  • Hepatic dysfunction: elevated liver enzymes or hepatitis.
  • Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.

Precautions & Warnings

When prescribing Montelukast, clinicians should consider several safety measures to optimize patient outcomes.

  • Assess asthma control: ensure baseline therapy is adequate before adding Montelukast.
  • Monitor neuropsychiatric symptoms: watch for mood changes or suicidal ideation.
  • Use caution in hepatic impairment: adjust use if liver disease is present.
  • Avoid in known hypersensitivity: discontinue if allergic reaction occurs.
  • Not for acute asthma attacks: it does not provide immediate bronchodilation.
  • Store at room temperature: keep in the original packaging, protect from moisture and heat.

Avoid Interactions

Montelukast can interact with other medicines, influencing its plasma levels or safety profile.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir): may increase Montelukast exposure.
  • Strong CYP2C9 inhibitors (e.g., fluconazole): can raise drug concentrations.
  • Concurrent use with potent enzyme inducers such as phenobarbital or rifampin: may reduce efficacy significantly.

Moderate Interactions (Monitor Closely)

  • Warfarin: potential alteration of anticoagulant effect.
  • Theophylline: possible additive bronchial effects.
  • Antidepressants (e.g., SSRIs): monitor for enhanced neuropsychiatric side effects.
  • St. John’s wort herbal supplement: may lower Montelukast levels.

Frequently Asked Questions

Montelukast Ratiopharm is prescribed for the long‑term management of asthma, to prevent exercise‑induced bronchoconstriction, and to relieve symptoms of allergic rhinitis such as nasal congestion, sneezing, and itchy eyes. It is used in both adult and pediatric patients as part of a comprehensive asthma or allergy treatment plan.

Montelukast works by selectively blocking the cysteinyl leukotriene receptor CysLT1. This inhibition prevents leukotrienes D4, C4 and E4 from binding, which reduces bronchoconstriction, vascular permeability, and eosinophilic inflammation in the airways, thereby improving breathing and decreasing allergic inflammation.

The appropriate dose of Montelukast Ratiopharm is determined by the prescribing healthcare professional based on the patient’s age, weight, severity of disease, and response to therapy. No specific dosing regimen is provided here; patients should follow the prescriber’s instructions and the product label.

Safety data for Montelukast during pregnancy and lactation are limited. The drug should only be used if the potential benefit justifies any potential risk to the fetus or infant. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss the risks and benefits with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity of Montelukast Ratiopharm. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.

Montelukast belongs to the leukotriene receptor antagonist class, offering an oral alternative to inhaled corticosteroids or long‑acting beta‑agonists. It is particularly useful for patients with aspirin‑sensitive asthma or those who need additional control of allergic rhinitis. Unlike bronchodilators, it does not provide immediate relief of acute bronchospasm.

Montelukast Ratiopharm should be stored at room temperature, below 25 °C. Keep the tablets in the original packaging, protect them from moisture, direct sunlight and excessive heat to maintain product stability throughout its shelf life.

The medication is taken orally as a tablet. Patients should swallow the tablet whole with water, and it may be taken with or without food. It is not intended for use as a rescue medication during an acute asthma attack.

Serious risks include neuropsychiatric events such as mood changes, agitation, or suicidal thoughts, as well as severe allergic reactions like rash, angioedema, and rare skin conditions such as Stevens‑Johnson syndrome. Hepatic dysfunction, although uncommon, may also occur and requires monitoring of liver function if clinically indicated.

Montelukast should be avoided in individuals with known hypersensitivity to the drug or any of its excipients. It is not suitable for treating acute asthma attacks, and patients with severe hepatic impairment should use it only under close medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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