Product image of Montelukast Ratiopharm (Montelukast Sodium) supplied by GNH India

Montelukast Ratiopharm

Active Ingredient:
Montelukast Sodium
Origin:
EU

Montelukast Ratiopharm (Montelukast Sodium)

Montelukast, the active ingredient in Montelukast Ratiopharm, is a leukotriene receptor antagonist presented as a tablet for oral use. It is employed to manage asthma and allergic rhinitis by reducing inflammation and bronchoconstriction in patients of all ages.

GNH India supplies Montelukast Ratiopharm as a licensed, GDP‑compliant international pharmaceutical supplier, ensuring quality and regulatory compliance while serving hospitals, pharmacies and clinics worldwide. Our global distribution network facilitates reliable delivery across Europe, Asia, Africa and the Americas. We adhere to stringent quality assurance protocols to meet the expectations of healthcare professionals.

Manufacturer / TM Owner

Teva Pharma S.L.U.,

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Indications & Clinical Uses

Montelukast acts on the leukotriene pathway to control respiratory and allergic conditions.

  • Asthma: improves symptom control and reduces the frequency of exacerbations.
  • Allergic rhinitis: alleviates nasal congestion, sneezing, itching and rhinorrhoea.
  • Exercise‑induced bronchoconstriction: helps prevent airway narrowing during physical activity.

How It Works

  • Montelukast selectively blocks the cysteinyl leukotriene receptor CysLT1, preventing leukotrienes from binding to airway smooth‑muscle and inflammatory cells. This inhibition reduces leukotriene‑mediated bronchoconstriction, vascular permeability, mucus secretion and eosinophilic inflammation, thereby improving airway patency and decreasing allergic inflammation.

Side Effects

Montelukast is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Headache: mild to moderate pain often reported.
  • Abdominal pain: discomfort in the stomach region.
  • Cough: transient irritation of the airway.
  • Nausea: feeling of queasiness.
  • Diarrhoea: loose stools.
  • Fatigue: unusual tiredness.

Serious or Rare Side Effects

  • Allergic reactions: rash, urticaria, angioedema, or anaphylaxis.
  • Mood changes: depression, suicidal thoughts or behaviour.
  • Hepatic enzyme elevation: abnormal liver function tests.
  • Neutropenia: reduced white‑blood‑cell count.
  • Stevens‑Johnson syndrome: severe skin and mucous membrane disorder.

Precautions & Warnings

Before prescribing Montelukast, clinicians should consider several safety aspects.

  • Assess liver function: monitor hepatic enzymes in patients with known liver disease.
  • Avoid use in patients with known hypersensitivity: discontinue if allergic reaction occurs.
  • Use caution in patients with psychiatric disorders: monitor for mood changes or suicidal ideation.
  • Consider dose adjustment in severe renal impairment: evaluate renal function before initiation.
  • Store at room temperature: keep in the original pack, protect from moisture and direct sunlight.

Avoid Interactions

Montelukast may interact with other medicines, requiring attention to the level of interaction.

Major Interactions (Avoid)

  • Ritonavir: can increase montelukast plasma concentrations.
  • Phenobarbital: may reduce montelukast effectiveness.
  • Ketoconazole: may elevate montelukast levels.

Moderate Interactions (Monitor Closely)

  • Warfarin: possible alteration of INR, requiring coagulation monitoring.
  • Theophylline: additive bronchial effects may require dose review.
  • Fluconazole: may modestly increase montelukast exposure.

Frequently Asked Questions

Montelukast Ratiopharm is indicated for the long‑term management of asthma, for relief of symptoms of allergic rhinitis, and for the prevention of exercise‑induced bronchoconstriction. By targeting leukotriene‑mediated inflammation, it helps improve breathing and reduce nasal allergy symptoms in both adults and children.

Montelukast selectively antagonises the cysteinyl leukotriene receptor CysLT1, blocking the action of leukotrienes that cause airway smooth‑muscle constriction, mucus production and inflammatory cell recruitment. This results in decreased bronchoconstriction and reduced inflammation of the respiratory tract.

The dosage of Montelukast Ratiopharm is determined by the prescribing clinician based on the patient’s age, weight, indication and clinical response. Healthcare professionals follow local prescribing guidelines and adjust the regimen as needed; patients should follow the prescriber’s instructions exactly.

The pregnancy category for Montelukast is not definitively established, and limited data are available. It should only be used during pregnancy or lactation if the potential benefit justifies any potential risk to the fetus or infant. The prescriber will evaluate individual circumstances before recommending therapy.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Montelukast belongs to the leukotriene receptor antagonist class, offering an oral alternative to inhaled corticosteroids or long‑acting beta‑agonists. It is especially useful for patients who prefer oral therapy or have aspirin‑exacerbated respiratory disease. While inhaled steroids target a broader range of inflammatory pathways, Montelukast specifically blocks leukotriene‑mediated effects.

Montelukast Ratiopharm tablets should be stored at room temperature, below 25 °C, in the original packaging to protect them from moisture and light. Keep the product out of reach of children and avoid storing in humid or excessively hot environments.

The medication is taken orally as a whole tablet, with or without food, according to the prescriber’s directions. Swallow the tablet whole; do not crush, chew, or split it unless specifically instructed by a healthcare professional.

Serious adverse events, although rare, include severe allergic reactions such as rash, angioedema or anaphylaxis, and neuropsychiatric effects like depression, suicidal thoughts, or behavioural changes. Hepatic enzyme elevations and rare skin disorders such as Stevens‑Johnson syndrome have also been reported. Prompt medical attention is required if any of these occur.

Montelukast Ratiopharm is contraindicated in individuals with known hypersensitivity to montelukast or any of the tablet’s excipients. Caution is advised for patients with severe hepatic impairment, and it should be used only under close supervision in those with a history of psychiatric disorders.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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