Product image of Montelukast Sandoz (Montelukast) supplied by GNH India

Montelukast Sandoz

Active Ingredient:
Montelukast
Origin:
EU

Montelukast Sandoz (Montelukast)

Montelukast, the active ingredient in Montelukast Sandoz, is a leukotriene receptor antagonist presented as an oral dosage form for oral use. It treats asthma and allergic rhinitis in adults and children as prescribed.

GNH India supplies Montelukast Sandoz as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sandoz A/S

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Indications & Clinical Uses

Montelukast is a leukotriene‑receptor antagonist used in the management of several airway‑related conditions.

  • Asthma: improves long‑term control and reduces the frequency of exacerbations.
  • Allergic rhinitis: relieves nasal congestion, sneezing, itching and rhinorrhea.
  • Exercise‑induced bronchoconstriction: prevents airway narrowing triggered by physical activity.

How It Works

  • Montelukast selectively blocks the cysteinyl leukotriene receptor CysLT1, preventing leukotrienes D4, E4 and F4 from binding. By inhibiting this pathway, it reduces bronchial smooth‑muscle contraction, vascular permeability, mucus secretion and inflammatory cell recruitment that contribute to asthma and allergic rhinitis symptoms.

Side Effects

Montelukast may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Abdominal pain: occasional discomfort.
  • Cough: transient irritation.
  • Dyspepsia: indigestion or upset stomach.
  • Nausea: occasional queasiness.
  • Dizziness: brief light‑headedness.

Serious or Rare Side Effects

  • Angioedema: swelling of face, lips or tongue.
  • Anaphylaxis: severe allergic reaction requiring immediate care.
  • Neuropsychiatric events: mood changes, depression or suicidal thoughts.
  • Hepatic enzyme elevation: abnormal liver function tests.
  • Severe rash or Stevens‑Johnson syndrome: extensive skin involvement.
  • Bronchospasm: paradoxical worsening of breathing.

Precautions & Warnings

Before initiating therapy, consider the following safety measures.

  • Monitor neuropsychiatric symptoms: watch for mood changes or depression.
  • Assess liver function: use caution in patients with hepatic impairment.
  • Use carefully in severe asthma: not a rescue medication for acute attacks.
  • Avoid in patients with known hypersensitivity to montelukast or any tablet components.
  • Store below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Montelukast can interact with other medicines that affect its metabolism or pharmacodynamic profile.

Major Interactions (Avoid)

  • Rifampin: strong enzyme inducer that may reduce montelukast exposure.
  • Ketoconazole: potent CYP3A4 inhibitor that can increase drug levels.
  • Phenobarbital: enzyme inducer that may lower efficacy.

Moderate Interactions (Monitor Closely)

  • Warfarin: possible alteration of anticoagulant effect, monitor INR.
  • Other leukotriene modifiers (e.g., zafirlukast): additive pharmacologic effect.
  • Beta‑agonists: may require dose adjustment for optimal asthma control.

Frequently Asked Questions

Montelukast Sandoz is prescribed to manage asthma, allergic rhinitis, and exercise‑induced bronchoconstriction. It helps control chronic airway inflammation, reduces symptoms such as wheezing, nasal congestion, sneezing, and prevents exercise‑related narrowing of the airways.

Montelukast works by selectively blocking the cysteinyl leukotriene receptor CysLT1. This inhibition prevents leukotrienes D4, E4 and F4 from triggering bronchial smooth‑muscle contraction, mucus production, and inflammatory cell recruitment, thereby reducing airway narrowing and allergic symptoms.

The appropriate dose of Montelukast Sandoz is determined by the prescribing healthcare professional based on the patient’s age, condition severity and response to therapy. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for Montelukast use in pregnancy and lactation are limited. Healthcare providers weigh potential benefits against risks before prescribing it to pregnant or nursing women. Patients should discuss any concerns with their doctor before starting therapy.

To order Montelukast Sandoz, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and necessary import documentation.

Montelukast belongs to the leukotriene receptor antagonist class, offering an oral alternative to inhaled corticosteroids and long‑acting beta‑agonists. It is particularly useful for patients with allergic components or exercise‑induced bronchoconstriction, but it is not a rescue medication for acute attacks.

Montelukast Sandoz should be stored at room temperature, below 25 °C. Keep the tablets in their original packaging, protect them from moisture and direct sunlight, and ensure they are out of reach of children.

Montelukast Sandoz is taken orally, usually once daily in the evening, with or without food. The tablet should be swallowed whole with a glass of water. Patients must follow the dosing schedule prescribed by their healthcare provider.

Serious risks include neuropsychiatric events such as mood changes, depression or suicidal thoughts, as well as rare allergic reactions like angioedema and anaphylaxis. Any sudden or severe symptoms should prompt immediate medical attention.

Montelukast Sandoz should be avoided in individuals with known hypersensitivity to montelukast or any of its tablet components. It is also not suitable as a rescue medication for acute asthma attacks and should be used with caution in patients with severe hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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