Product image of Moнтелукаст Акорд (Montelukast Sodium) supplied by GNH India

Moнтелукаст Акорд

Active Ingredient:
Montelukast Sodium
Origin:
EU

Moнтелукаст Акорд (Montelukast Sodium)

Montelukast Sodium, the active ingredient in Moнтелукаст Акорд, is a leukotriene receptor antagonist presented as an oral tablet for oral use. It is used for maintenance therapy of asthma and for relief of symptoms of allergic rhinitis in adults and children.

GNH India supplies Moнтелукаст Акорд as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Accord Healthcare Polska Sp. Z O.O.

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Indications & Clinical Uses

Montelukast works within the leukotriene pathway to manage chronic respiratory conditions.

  • Asthma: reduces frequency and severity of bronchospasm and improves overall control.
  • Allergic rhinitis: alleviates nasal congestion, sneezing and itchy eyes associated with seasonal allergies.
  • Exercise‑induced bronchoconstriction: helps prevent airway narrowing during physical activity.

How It Works

  • Montelukast Sodium selectively blocks the cysteinyl leukotriene receptor CysLT1, preventing leukotrienes D4, E4 and related mediators from binding. This inhibition reduces bronchoconstriction, vascular permeability, mucus secretion and inflammatory cell recruitment in the airways, thereby improving respiratory function and decreasing allergic inflammation.

Side Effects

Montelukast is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Headache: mild to moderate discomfort often reported.
  • Abdominal pain: intermittent stomach discomfort.
  • Cough: occasional dry cough.
  • Nausea: feeling of queasiness.
  • Dizziness: transient light‑headedness.
  • Fatigue: unusual tiredness.

Serious or Rare Side Effects

  • Allergic reactions: rash, angioedema or anaphylaxis.
  • Neuropsychiatric events: mood changes, depression or suicidal thoughts.
  • Hepatic injury: elevated liver enzymes or hepatitis.
  • Stevens‑Johnson syndrome: severe skin reactions.
  • Eosinophilic granulomatosis with polyangiitis: rare vasculitis.
  • Blood dyscrasias: rare blood cell abnormalities.

Precautions & Warnings

Before prescribing Montelukast, clinicians should consider several safety aspects.

  • Pregnancy: safety data are limited; use only if clearly needed.
  • Breastfeeding: montelukast is excreted in milk; weigh benefits against potential risks.
  • Hepatic impairment: monitor liver function and adjust use if necessary.
  • Neuropsychiatric monitoring: observe patients for mood changes or suicidal ideation.
  • Hypersensitivity: discontinue if allergic reaction occurs.
  • Store at room temperature: keep in the original container, protect from moisture and heat.

Avoid Interactions

Montelukast may interact with other medicines that affect its metabolism or pharmacodynamic profile.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase montelukast plasma levels.
  • Phenobarbital, carbamazepine, phenytoin: may significantly reduce montelukast exposure.

Moderate Interactions (Monitor Closely)

  • Ritonavir: can raise montelukast concentrations.
  • Warfarin: occasional reports of altered INR; monitor coagulation.
  • Theophylline: may require dose adjustment of the bronchodilator.
  • Antidepressants: monitor for additive neuropsychiatric effects.

Frequently Asked Questions

Moнтелукаст Акорд contains montelukast sodium, which is prescribed for the long‑term management of asthma and for relief of symptoms associated with allergic rhinitis, including nasal congestion, sneezing and itchy eyes. It may also be used to prevent exercise‑induced bronchoconstriction in patients with asthma.

Montelukast sodium selectively blocks the cysteinyl leukotriene receptor CysLT1, preventing leukotrienes D4, E4 and related mediators from triggering bronchoconstriction, mucus production and inflammation in the airways. By inhibiting this pathway, it helps keep the airways open and reduces allergic inflammation.

The appropriate dose of Moнтелукаст Акорд is determined by the prescribing healthcare professional based on the patient’s age, weight, disease severity and other clinical factors. Patients should follow the exact regimen provided by their prescriber and not adjust the dose on their own.

Safety data for montelukast during pregnancy are limited, so it should only be used if the potential benefit justifies any potential risk to the fetus. Montelukast is excreted in breast milk; therefore, nursing mothers should discuss the risks and benefits with their healthcare provider before using the product.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Montelukast belongs to the leukotriene receptor antagonist class, offering an oral alternative to inhaled corticosteroids or long‑acting beta‑agonists. It is particularly useful for patients who have difficulty using inhalers or who need additional control of allergic components of asthma. Its safety profile differs from steroids, with fewer local airway side effects but a distinct set of systemic adverse reactions.

Moнтелукаст Акорд should be stored at room temperature, below 25 °C, in its original packaging. Protect the tablets from moisture, direct sunlight and excessive heat to maintain potency throughout the shelf life.

The medication is taken orally, usually once daily in the evening, with or without food, as directed by the prescriber. Swallow the tablet whole; do not crush, chew, or split it unless specifically instructed by a healthcare professional.

Serious risks, though rare, include severe allergic reactions such as rash, angioedema or anaphylaxis, as well as neuropsychiatric events like depression, mood swings or suicidal thoughts. Hepatic injury and rare skin conditions such as Stevens‑Johnson syndrome have also been reported. Patients should seek immediate medical attention if any of these symptoms appear.

Montelukast should be avoided in individuals with known hypersensitivity to montelukast sodium or any of the tablet’s excipients. Caution is advised for patients with severe liver disease, uncontrolled psychiatric conditions, or those taking medications that may cause significant drug interactions. A healthcare professional should evaluate suitability before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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