Product image of Montelukast Sumar Pharma (Montelukast Sodium) supplied by GNH India

Montelukast Sumar Pharma

Active Ingredient:
Montelukast Sodium
Origin:
EU

Montelukast Sumar Pharma (Montelukast Sodium)

Montelukast Sodium, the active ingredient in Montelukast Sumar Pharma, is a leukotriene receptor antagonist presented as an oral dosage form for systemic use. It is indicated for maintenance therapy of asthma, relief of allergic rhinitis symptoms, and prevention of exercise‑induced bronchoconstriction in adults and children.

GNH India supplies Montelukast Sumar Pharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation to support import and distribution.

Manufacturer / TM Owner

Alvogen Ehf

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Indications & Clinical Uses

  • Montelukast Sumar Pharma, a leukotriene receptor antagonist, is used to manage conditions driven by cysteinyl leukotriene–mediated inflammation.
  • Asthma: reduces frequency of bronchospasm and improves overall disease control.
  • Allergic rhinitis: alleviates nasal congestion, sneezing and itchy eyes.
  • Exercise‑induced bronchoconstriction: prevents airway narrowing during physical activity.

How It Works

  • Montelukast selectively blocks the cysteinyl leukotriene receptor type 1 (CysLT1) on airway smooth‑muscle cells, submucosal glands and inflammatory cells. By preventing leukotriene D4 binding, it inhibits bronchoconstriction, mucus secretion, vascular permeability and eosinophil recruitment, thereby reducing airway inflammation and hyper‑responsiveness associated with asthma and allergic rhinitis. The antagonism is dose‑dependent and persists for 24 hours, supporting once‑daily dosing in most patients and contributes to improved symptom control.

Side Effects

Montelukast is generally well tolerated, but several adverse reactions have been reported.

Common Side Effects

  • Headache
  • Abdominal pain
  • Cough
  • Dyspepsia
  • Fatigue
  • Nausea

Serious or Rare Side Effects

  • Angioedema
  • Stevens‑Johnson syndrome
  • Eosinophilic granulomatosis with polyangiitis
  • Hepatic injury
  • Anaphylaxis
  • Mood changes, including depression or suicidal thoughts

Precautions & Warnings

  • When prescribing Montelukast, clinicians should consider several precautionary measures to ensure safe use.
  • Neuropsychiatric monitoring: observe patients for mood changes, depression or suicidal thoughts.
  • Hepatic function: assess liver status in patients with existing hepatic disease.
  • Severe asthma: use as add‑on therapy and continue other controller medications.
  • Concomitant drugs: review for potential interactions, especially CYP3A4 modulators.
  • Hypersensitivity: discontinue if signs of allergic reaction appear.
  • Store at ambient temperature: keep in original packaging, protect from moisture and heat.

Avoid Interactions

Montelukast may interact with other medicines that affect its metabolism or pharmacodynamic profile.

Major Interactions (Avoid)

  • Rifampin: strong CYP3A4 inducer that may reduce montelukast plasma levels.
  • Phenobarbital: enzyme inducer leading to decreased efficacy.
  • Ketoconazole: potent CYP3A4 inhibitor that can increase montelukast exposure.

Moderate Interactions (Monitor Closely)

  • Fluconazole: moderate CYP3A4 inhibition, may raise drug levels.
  • Erythromycin: can increase montelukast concentrations.
  • Warfarin: potential for altered anticoagulant effect, monitor INR.
  • Theophylline: monitor for additive bronchial effects.

Frequently Asked Questions

Montelukast Sumar Pharma is prescribed for the maintenance treatment of asthma, relief of symptoms associated with allergic rhinitis, and prevention of exercise‑induced bronchoconstriction. It targets the underlying leukotriene‑mediated inflammation that contributes to airway narrowing and nasal congestion.

Montelukast Sodium acts as a selective antagonist of the cysteinyl leukotriene receptor CysLT1. By blocking this receptor, it prevents leukotriene D4 from triggering bronchoconstriction, mucus production, vascular leakage, and eosinophil recruitment, thereby reducing airway inflammation and hyper‑responsiveness.

The appropriate dose of Montelukast Sumar Pharma is determined by the prescribing healthcare professional based on the patient’s age, clinical condition, and response to therapy. Dosage instructions are provided on the prescription label and should be followed exactly as directed.

The safety of Montelukast Sumar Pharma in pregnancy and lactation has not been definitively established. Healthcare providers weigh potential benefits against possible risks before prescribing it to pregnant or nursing individuals, and patients should discuss any concerns with their clinician.

To request Montelukast Sumar Pharma, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Montelukast belongs to the leukotriene receptor antagonist class, offering an oral alternative to inhaled corticosteroids or long‑acting beta‑agonists. It is particularly useful for patients with aspirin‑exacerbated respiratory disease or those who prefer a once‑daily tablet, but it may be less potent than inhaled steroids for severe asthma control.

Montelukast Sumar Pharma should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

Montelukast Sumar Pharma is taken orally, usually as a tablet, with or without food. The medication is typically taken once daily in the evening, but the exact timing and administration instructions are provided by the prescribing clinician.

Serious adverse reactions, although rare, include angioedema, severe skin reactions such as Stevens‑Johnson syndrome, eosinophilic granulomatosis with polyangiitis, hepatic injury, anaphylaxis, and neuropsychiatric events like depression or suicidal thoughts. Patients should seek immediate medical attention if any of these occur.

Montelukast Sumar Pharma should be avoided in individuals with a known hypersensitivity to montelukast or any of its excipients. It is also contraindicated in patients who have experienced severe allergic reactions to leukotriene‑modifying agents. Clinicians should assess each patient’s medical history before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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