Product image of Montelukast Synthon (Montelukast) supplied by GNH India

Montelukast Synthon

Active Ingredient:
Montelukast
Origin:
EU

Montelukast Synthon (Montelukast)

Montelukast, the active ingredient in Montelukast Synthon, is a leukotriene receptor antagonist presented as an oral dosage form for oral use. It is employed to manage asthma, allergic rhinitis, and exercise‑induced bronchoconstriction in adults and children.

GNH India supplies Montelukast Synthon as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable global distribution.

Manufacturer / TM Owner

Synthon Bv

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Indications & Clinical Uses

Montelukast acts on the leukotriene pathway to control inflammatory airway conditions.

  • Asthma: reduces the frequency of wheezing episodes and improves overall lung function.
  • Allergic rhinitis: alleviates nasal congestion, sneezing, itching and rhinorrhoea.
  • Exercise‑induced bronchoconstriction: prevents airway narrowing that occurs during physical activity.

How It Works

  • Montelukast selectively blocks the cysteinyl leukotriene receptor CysLT1, preventing leukotriene D4 and related mediators from binding. This inhibition reduces bronchoconstriction, vascular permeability, mucus secretion, and inflammatory cell recruitment in the airways, thereby improving respiratory symptoms associated with asthma and allergic conditions.

Side Effects

Montelukast may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Abdominal pain: occasional discomfort.
  • Cough: transient irritation.
  • Nausea or diarrhea: gastrointestinal upset.
  • Fatigue: feeling of reduced energy.

Serious or Rare Side Effects

  • Allergic reactions: rash, urticaria, or angioedema.
  • Neuropsychiatric events: mood changes, depression, or suicidal thoughts.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Hepatic injury: elevated liver enzymes or jaundice.

Precautions & Warnings

When prescribing Montelukast, consider the following safety measures.

  • Pregnancy: consult a healthcare professional before use.
  • Breastfeeding: discuss potential risks with a physician.
  • Liver impairment: use with caution and monitor hepatic function.
  • Concomitant phenobarbital: may reduce drug effectiveness.
  • Neuropsychiatric monitoring: report any mood changes or unusual behavior.
  • Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Montelukast can interact with several medicines; awareness of the interaction level is essential.

Major Interactions (Avoid)

  • Ritonavir: may increase plasma concentrations of Montelukast.
  • Phenobarbital: may decrease Montelukast effectiveness.

Moderate Interactions (Monitor Closely)

  • Fluconazole: potential increase in Montelukast levels.
  • Erythromycin: may raise systemic exposure.
  • Warfarin: monitor INR as interaction is possible.

Frequently Asked Questions

Montelukast Synthon is used to treat chronic asthma, relieve symptoms of allergic rhinitis, and prevent exercise‑induced bronchoconstriction. It works by targeting inflammatory pathways that cause airway narrowing and nasal inflammation.

Montelukast blocks the cysteinyl leukotriene receptor CysLT1, preventing leukotriene D4 and related mediators from binding. This inhibition reduces bronchoconstriction, mucus production, and inflammation in the respiratory tract, helping to control asthma and allergy symptoms.

The appropriate dose is determined by the prescribing clinician based on the patient’s age, condition, and response to therapy. Dosage forms and strengths are selected to match the individual treatment plan.

Safety data are limited. Women who are pregnant or breastfeeding should discuss potential risks and benefits with their healthcare provider before starting Montelukast Synthon.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Montelukast belongs to the leukotriene receptor antagonist class, offering an oral alternative to inhaled corticosteroids or long‑acting bronchodilators. It is particularly useful for patients with aspirin‑sensitive asthma or those who need additional control beyond inhaled therapy.

Store Montelukast Synthon at temperatures below 25 °C, in its original container, protected from moisture and direct sunlight. Keep out of reach of children and do not use if the packaging is damaged.

Montelukast is taken orally, usually as a tablet or chewable form, once daily in the evening. It should be swallowed whole with water unless a specific formulation advises otherwise.

Serious risks include severe allergic reactions such as angioedema, rare skin conditions like Stevens‑Johnson syndrome, and neuropsychiatric events including mood changes, depression, or suicidal thoughts. Any of these symptoms require immediate medical attention.

Montelukast is contraindicated in individuals with known hypersensitivity to the drug or any of its excipients. Caution is advised for patients with severe liver impairment, and it should be avoided in those taking medications that have major interactions without professional supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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