Montelukast Teva (Montelukast Sodium)

Montelukast Teva is a leukotriene receptor antagonist used in the management of several respiratory allergic conditions.

• Asthma: improves control of chronic airway inflammation and reduces frequency of exacerbations.
• Allergic rhinitis: relieves nasal congestion, sneezing and itching caused by seasonal or perennial allergens.
• Exercise‑induced bronchoconstriction: prevents airway narrowing that occurs during or after physical activity.

• Montelukast selectively blocks the cysteinyl leukotriene receptor CysLT1, preventing leukotriene D4 from binding. This inhibition reduces leukotriene‑mediated bronchoconstriction, mucus secretion, vascular permeability, and inflammatory cell recruitment in the airways, thereby improving respiratory function and symptom control.

Montelukast is generally well tolerated, but adverse reactions can occur.

Common Side Effects

• Headache: mild to moderate pain often transient.
• Abdominal pain: discomfort or cramps in the stomach region.
• Nausea: feeling of queasiness without vomiting.
• Dizziness: light‑headed sensation, especially on standing.
• Fatigue: unusual tiredness or lack of energy.
• Cough: mild irritation of the throat.

Serious or Rare Side Effects

• Allergic reactions: rash, angioedema, or hives requiring medical attention.
• Neuropsychiatric events: mood changes, agitation, or suicidal thoughts.
• Hepatic enzyme elevation: abnormal liver function tests observed in laboratory monitoring.

When prescribing Montelukast, clinicians should consider several safety aspects.

• Monitor liver function: periodic testing is advised for patients with hepatic disease.
• Caution in psychiatric history: observe for mood alterations or suicidal ideation.
• Avoid in known hypersensitivity: discontinue if allergic reaction occurs.
• Adjust in renal impairment: dose may need modification in severe kidney disease.
• Pregnancy and lactation: use only if potential benefit outweighs risk.
• Store at room temperature: keep in the original pack, protect from moisture and direct sunlight.

Montelukast may interact with other medicines, affecting efficacy or safety.

Major Interactions (Avoid)

• Strong CYP3A4 inhibitors (e.g., ketoconazole): may increase systemic exposure.
• Rifampin or other enzyme inducers: can markedly reduce therapeutic effect.

Moderate Interactions (Monitor Closely)

• Antidepressants (SSRIs, SNRIs): may heighten risk of neuropsychiatric side effects.
• NSAIDs: combined use may increase gastrointestinal discomfort.
• Theophylline: additive bronchodilator effect may require dose adjustment.