Product image of Montelukast Unimark (Montelukast) supplied by GNH India

Montelukast Unimark

Active Ingredient:
Montelukast
Origin:
EU

Montelukast Unimark (Montelukast)

Montelukast, the active ingredient in Montelukast Unimark, is a leukotriene receptor antagonist presented as an oral tablet for oral use. It is indicated for the management of asthma, allergic rhinitis and exercise‑induced bronchoconstriction, providing symptom control in both adult and pediatric populations across the European Union.

GNH India supplies Montelukast Unimark as a licensed, GDP‑compliant international pharmaceutical supplier, adhering to EU quality standards and serving hospitals, pharmacies, and clinics worldwide with reliable global logistics and regulatory support for a broad range of therapeutic needs.

Manufacturer / TM Owner

Unimark Remedies Sro

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Indications & Clinical Uses

  • Montelukast acts on the leukotriene pathway to manage chronic respiratory and allergic conditions.
  • Asthma: improves control of symptoms and reduces frequency of bronchospasm.
  • Allergic rhinitis: relieves nasal congestion, sneezing and itching.
  • Exercise‑induced bronchoconstriction: prevents airway narrowing triggered by physical activity.

How It Works

  • Montelukast is a selective antagonist of the cysteinyl leukotriene receptor CysLT1. By binding to this receptor, it blocks the action of leukotriene D4 and related mediators, which normally cause bronchial smooth‑muscle contraction, vascular permeability and inflammatory cell recruitment. The inhibition reduces bronchoconstriction and airway inflammation, contributing to improved respiratory function in susceptible patients.

Side Effects

Montelukast may be associated with a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Headache
  • Abdominal pain
  • Nausea

Serious or Rare Side Effects

  • Angioedema
  • Stevens‑Johnson syndrome
  • Eosinophilic granulomatosis with polyangiitis

Precautions & Warnings

  • When prescribing Montelukast, clinicians should consider several precautionary measures to ensure safe use.
  • Pregnancy: safety not established; use only if potential benefit justifies the risk.
  • Breastfeeding: unknown excretion; weigh maternal benefit against possible infant exposure.
  • Hepatic impairment: use with caution and monitor liver function tests.
  • Concomitant enzyme inducers: drugs such as phenobarbital or rifampin may lower montelukast plasma levels.
  • Age restrictions: not recommended for children under 12 months of age.
  • Store at ambient temperature below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Montelukast can interact with other medicines, influencing its efficacy or safety.

Major Interactions (Avoid)

  • Phenobarbital: may decrease montelukast plasma concentrations, reducing therapeutic effect.
  • Rifampin: strong enzyme induction can lower drug exposure and compromise control of symptoms.
  • Strong CYP3A4 inhibitors: may increase montelukast levels and raise risk of adverse reactions.

Moderate Interactions (Monitor Closely)

  • Antidepressants (e.g., fluoxetine): potential for enhanced neuropsychiatric effects.
  • Warfarin: monitor INR as montelukast may affect anticoagulant metabolism.
  • Beta‑agonists: additive bronchodilation may increase risk of tachycardia.

Frequently Asked Questions

Montelukast Unimark is prescribed for the long‑term management of asthma, for relief of symptoms associated with allergic rhinitis, and to prevent exercise‑induced bronchoconstriction. These indications are supported by clinical guidelines that recognize leukotriene receptor antagonists as controller therapy for these respiratory and allergic disorders.

Montelukast selectively blocks the cysteinyl leukotriene receptor CysLT1, preventing leukotrienes from binding and triggering bronchial smooth‑muscle contraction, mucus secretion, and airway inflammation. By inhibiting this pathway, the drug reduces airway narrowing and inflammatory responses, leading to improved breathing and fewer allergy‑related symptoms.

The appropriate dose of Montelukast Unimark is determined by the prescribing clinician based on the patient’s age, weight, indication, and overall clinical status. Dosage recommendations are outlined in the product’s prescribing information, but the final regimen is individualized and should be confirmed by a qualified healthcare professional.

Safety data for Montelukast in pregnancy are limited, and the product is generally classified as a drug with unknown pregnancy risk. It should be used only if the potential benefit justifies any possible risk to the fetus. Excretion in breast milk is also not well defined, so a risk‑benefit assessment is required for nursing mothers.

To place an order, submit an enquiry on the Montelukast Unimark product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Montelukast belongs to the leukotriene receptor antagonist class, offering an oral alternative to inhaled corticosteroids and long‑acting beta‑agonists. While it is less potent than high‑dose inhaled steroids for severe asthma, it provides convenient once‑daily dosing and is especially useful for patients with aspirin‑exacerbated respiratory disease or those who prefer an oral regimen.

Montelukast Unimark should be stored at ambient temperature below 25 °C, protected from moisture and light. Keep the tablets in the original blister pack until use, and avoid storing them in bathrooms or other humid environments. Do not freeze the product.

Montelukast Unimark is supplied as oral tablets that are swallowed whole with water. The medication is taken once daily, preferably in the evening, unless the prescriber advises a different schedule. No food restrictions are required, but the tablet should not be chewed or crushed.

Serious adverse reactions, although rare, include angioedema, Stevens‑Johnson syndrome, and eosinophilic granulomatosis with polyangiitis. Neuropsychiatric events such as mood changes, depression, or suicidal thoughts have also been reported. Patients should be instructed to seek immediate medical attention if they experience swelling of the face or throat, skin rash, or significant changes in mood.

Montelukast Unimark is contraindicated in patients with known hypersensitivity to montelukast or any of the tablet excipients. It is also not recommended for children younger than 12 months of age. Caution is advised in patients with severe hepatic impairment, and clinicians should evaluate the risk‑benefit profile before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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