Product image of Montelukast Zentiva (Montelukast Sodium) supplied by GNH India

Montelukast Zentiva

Active Ingredient:
Montelukast Sodium
Origin:
EU

Montelukast Zentiva (Montelukast Sodium)

Montelukast sodium, the active ingredient in Montelukast Zentiva, is a leukotriene receptor antagonist presented as an oral tablet for oral use. It is used to treat asthma, allergic rhinitis and exercise‑induced bronchoconstriction in adults and children.

GNH India supplies Montelukast Zentiva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Zentiva Italia S.R.L.

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Indications & Clinical Uses

Montelukast Zentiva acts on the leukotriene pathway to manage chronic respiratory conditions.

  • Asthma: improves long‑term control and reduces frequency of symptoms.
  • Allergic rhinitis: relieves nasal congestion, sneezing and itchy eyes.
  • Exercise‑induced bronchoconstriction: prevents airway narrowing during physical activity.

How It Works

  • Montelukast sodium selectively antagonizes the cysteinyl leukotriene receptor CysLT1, blocking the actions of leukotriene D4 and related mediators. By inhibiting this receptor, it reduces bronchoconstriction, mucus secretion, vascular permeability, and inflammatory cell recruitment in the airways, thereby improving respiratory function.

Side Effects

Montelukast may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Abdominal pain: occasional discomfort.
  • Cough: non‑productive.
  • Nausea: occasional upset stomach.
  • Dizziness: transient light‑headedness.
  • Fatigue: general tiredness.

Serious or Rare Side Effects

  • Allergic reactions: rash, angioedema, or anaphylaxis.
  • Neuropsychiatric events: depression, mood changes, or suicidal thoughts.
  • Hepatic enzyme elevation: abnormal liver function tests.
  • Blood dyscrasias: neutropenia or eosinophilia.
  • Severe skin reactions: Stevens‑Johnson syndrome.

Precautions & Warnings

Before prescribing Montelukast Zentiva, clinicians should consider several safety aspects.

  • Liver impairment: assess hepatic function and adjust therapy if needed.
  • Neuropsychiatric monitoring: watch for mood changes, depression, or suicidal ideation.
  • Pregnancy: category B; discuss risks and benefits with the patient.
  • Acute asthma attacks: not indicated for immediate relief; use rescue inhalers instead.
  • Hypersensitivity: avoid in patients with known allergy to montelukast or excipients.
  • Store at below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Montelukast can interact with other medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

  • Rifampin: may significantly lower montelukast plasma concentrations.
  • Phenobarbital: can reduce drug exposure through enzyme induction.
  • Zafirlukast: concurrent use may increase risk of leukotriene‑related adverse effects.

Moderate Interactions (Monitor Closely)

  • Fluoxetine: may potentiate neuropsychiatric side effects.
  • Theophylline: monitor for enhanced bronchodilator effects.
  • Beta‑agonists: possible additive bronchodilation; observe clinical response.

Frequently Asked Questions

Montelukast Zentiva is prescribed for maintenance therapy of asthma, relief of allergic rhinitis symptoms, and prevention of exercise‑induced bronchoconstriction. It helps control chronic airway inflammation and reduces the frequency of asthma attacks and allergic nasal symptoms.

Montelukast selectively blocks the cysteinyl leukotriene receptor CysLT1, preventing leukotriene D4 and related mediators from binding. This inhibition reduces bronchoconstriction, mucus production, vascular leakage, and inflammatory cell recruitment, leading to improved airway patency and symptom control.

The appropriate dose of Montelukast Zentiva is determined by the prescribing healthcare professional based on the patient’s age, weight, and specific condition. Dosage instructions are individualized and should be followed exactly as written on the prescription label.

Montelukast is classified as pregnancy category B, indicating no evidence of risk in animal studies but limited human data. It may be used during pregnancy only if clearly needed. Small amounts are excreted in breast milk; nursing mothers should discuss potential risks with their physician.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Montelukast belongs to the leukotriene receptor antagonist class, offering an oral alternative to inhaled corticosteroids or long‑acting beta‑agonists. It is particularly useful for patients with aspirin‑sensitive asthma or those who prefer a once‑daily tablet, but it does not replace rescue inhalers for acute attacks.

Montelukast Zentiva tablets should be stored at temperatures below 25 °C, in their original packaging, and protected from moisture and direct sunlight. Do not store in bathrooms or near heat sources to maintain product stability.

Montelukast Zentiva is taken orally, usually once daily in the evening, with or without food. The tablet should be swallowed whole with a glass of water. Patients should follow the specific timing advised by their healthcare provider.

Serious risks include rare neuropsychiatric events such as depression, suicidal thoughts, and mood changes, as well as severe allergic reactions like rash, angioedema, or anaphylaxis. Liver enzyme elevations and blood dyscrasias have also been reported; any concerning symptoms should prompt immediate medical evaluation.

Montelukast is contraindicated in individuals with known hypersensitivity to montelukast sodium or any tablet excipients. It should not be used for acute asthma attacks, and patients with uncontrolled severe liver disease should avoid it unless specifically directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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