Product image of Montelukastum Unimark (Montelukast Sodium) supplied by GNH India

Montelukastum Unimark

Active Ingredient:
Montelukast Sodium
Origin:
EU

Montelukastum Unimark (Montelukast Sodium)

Montelukast Sodium, the active ingredient in Montelukastum Unimark, is a leukotriene receptor antagonist presented as an oral tablet for oral use. It is employed to manage asthma, allergic rhinitis, and exercise‑induced bronchoconstriction in adults and children, working by blocking cysteinyl leukotriene receptors and reducing airway inflammation.

GNH India supplies Montelukastum Unimark as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies, clinics and procurement teams worldwide.

Manufacturer / TM Owner

Unimark Remedies Sro

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Indications & Clinical Uses

Montelukastum Unimark, a leukotriene receptor antagonist, is indicated for conditions mediated by cysteinyl leukotrienes.

  • Asthma: Improves control of persistent asthma by reducing airway inflammation and preventing bronchoconstriction.
  • Allergic rhinitis: Relieves nasal congestion, sneezing and itching associated with seasonal or perennial allergic rhinitis.
  • Exercise‑induced bronchoconstriction: Prevents narrowing of the airways that can occur during or after physical exertion.

How It Works

  • Montelukast Sodium selectively antagonizes the cysteinyl leukotriene receptor CysLT1. By binding to this receptor it blocks the actions of leukotriene D4 and related mediators, which are responsible for bronchial smooth‑muscle contraction, vascular permeability, mucus secretion and eosinophil recruitment. This inhibition reduces airway inflammation and hyper‑responsiveness.

Side Effects

Montelukastum Unimark may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Headache: mild to moderate intensity, often transient.
  • Upper respiratory tract infection: nasopharyngitis‑like symptoms such as sore throat and runny nose.
  • Abdominal pain: discomfort or cramping in the stomach area.

Serious or Rare Side Effects

  • Allergic reactions: rash, urticaria, or angioedema that may require medical attention.
  • Neuropsychiatric events: agitation, anxiety, depression, or suicidal thoughts reported in rare cases.
  • Hepatotoxicity: elevated liver enzymes or clinically apparent hepatitis, requiring monitoring.

Precautions & Warnings

When prescribing Montelukastum Unimark, clinicians should consider several precautionary measures to ensure safe use.

  • Contraindication: known hypersensitivity to montelukast or any tablet excipients.
  • Caution in asthma: not a substitute for rescue bronchodilators; maintain short‑acting inhaler.
  • Pregnancy: limited data; use only if potential benefit justifies potential risk.
  • Breastfeeding: montelukast excreted in milk; weigh benefits against infant exposure.
  • Drug interactions: review concomitant medications that may affect leukotriene pathways.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture.

Avoid Interactions

Montelukast may interact with other medicines; awareness of major and moderate interactions helps avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

  • Phenobarbital, carbamazepine, rifampin: strong enzyme inducers that can lower montelukast plasma concentrations.
  • Ritonavir: may increase montelukast levels, raising risk of adverse effects.

Moderate Interactions (Monitor Closely)

  • Warfarin: potential alteration of anticoagulant effect; monitor INR.
  • Theophylline: additive bronchodilator effects; observe for increased side effects.
  • Zafirlukast: concurrent leukotriene receptor antagonists may increase risk of liver enzyme abnormalities.

Frequently Asked Questions

Montelukastum Unimark contains the leukotriene receptor antagonist montelukast sodium and is prescribed to treat persistent asthma, allergic rhinitis (both seasonal and perennial), and exercise‑induced bronchoconstriction. By targeting leukotriene pathways, it helps reduce airway inflammation and improves breathing in these conditions.

Montelukast Sodium works by selectively blocking the cysteinyl leukotriene receptor CysLT1. This prevents leukotriene D4 and related mediators from binding, which in turn reduces bronchial smooth‑muscle contraction, mucus production, vascular leakage, and eosinophil recruitment, leading to decreased airway inflammation and hyper‑responsiveness.

The exact dose of Montelukastum Unimark is determined by the prescribing healthcare professional based on the patient’s age, weight, severity of disease, and clinical response. Standard dosing guidelines exist for different indications, but the prescriber tailors the regimen to each individual’s needs.

Safety data for montelukast in pregnancy are limited, and the drug should only be used if the potential benefit outweighs any possible risk to the fetus. Montelukast is excreted in breast milk; therefore, breastfeeding mothers should discuss the risk‑benefit profile with their physician before continuing therapy.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity of Montelukastum Unimark. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Montelukast belongs to the leukotriene receptor antagonist class, offering an oral alternative to inhaled corticosteroids or other leukotriene blockers such as zafirlukast. Compared with inhaled steroids, montelukast provides a convenient once‑daily tablet but may be less potent for severe asthma; however, it is useful for patients who cannot tolerate inhaled therapy or need additional control.

Montelukastum Unimark should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original blister pack or container, protect them from moisture and direct sunlight, and avoid storing them in bathrooms or other humid environments to maintain product stability.

The medication is supplied as oral tablets that are swallowed whole with a glass of water. It is usually taken once daily, with or without food, as directed by the prescriber. Patients should not crush, chew, or split the tablets unless specifically instructed.

Serious adverse events, although rare, include severe allergic reactions such as rash, urticaria or angioedema, neuropsychiatric effects like agitation, depression or suicidal thoughts, and liver injury manifested by elevated enzymes or hepatitis. Any of these symptoms should prompt immediate medical evaluation.

Montelukastum Unimark is contraindicated in individuals with a known hypersensitivity to montelukast sodium or any of the tablet’s inactive ingredients. Caution is also advised for patients with uncontrolled asthma who rely on rescue inhalers, as the drug does not replace acute bronchodilator therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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