Product image of Morfeo (Zaleplon) supplied by GNH India

Morfeo

Active Ingredient:
Zaleplon
Origin:
EU

Morfeo (Zaleplon)

Zaleplon, the active ingredient in Morfeo, is a non‑benzodiazepine hypnotic (Z‑drug) presented as an oral tablet for oral use. It is indicated for the short‑term treatment of sleep onset insomnia in adult patients who have difficulty falling asleep.

GNH India supplies Morfeo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to strict quality standards and provides reliable sourcing for regulated markets. Our global logistics network ensures timely delivery and compliance with import regulations across continents.

Manufacturer / TM Owner

Adamed Pharma S.A.

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Indications & Clinical Uses

  • Zaleplon is a non‑benzodiazepine hypnotic used to manage sleep onset insomnia, a disorder characterized by difficulty initiating sleep.
  • Sleep onset insomnia: reduces sleep latency and helps patients fall asleep more quickly during short‑term therapy.
  • Transient insomnia due to stress: improves ability to initiate sleep in acute stress‑related episodes.
  • Acute insomnia after shift work: facilitates quicker sleep onset for individuals with temporary sleep disruption.

How It Works

  • Zaleplon acts as a positive allosteric modulator at the benzodiazepine binding site of the GABA_A receptor complex. By enhancing the inhibitory effect of GABA, it increases chloride ion influx, leading to neuronal hyperpolarization and reduced central nervous system activity, which promotes rapid sleep onset without markedly altering sleep architecture.

Side Effects

Common Side Effects

  • Dizziness
  • Headache
  • Nausea
  • Taste disturbance
  • Transient somnolence
  • Amnesia

Serious or Rare Side Effects

  • Severe allergic reactions (rash, swelling, anaphylaxis)
  • Complex sleep behaviors (sleep‑walking, sleep‑driving)
  • Depression or suicidal thoughts
  • Respiratory depression when combined with other CNS depressants
  • Hallucinations or psychomotor agitation

Precautions & Warnings

Before initiating therapy, evaluate the patient’s sleep disorder and medical history.

  • Concomitant CNS depressants: avoid or use with caution to prevent excessive sedation.
  • Hepatic impairment: adjust therapy as metabolism may be reduced.
  • Dependence risk: limit use to the shortest duration necessary.
  • Abrupt discontinuation: taper if therapy exceeds recommended period.

Store at ambient temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Zaleplon may interact with several drug classes that affect the central nervous system or its metabolism.

Major Interactions (Avoid)

  • Other hypnotics, benzodiazepines, opioids, or alcohol: may cause profound sedation and respiratory depression.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): can increase plasma concentrations and risk of adverse effects.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampin, carbamazepine): may reduce efficacy by lowering drug levels.
  • Certain antidepressants (e.g., fluoxetine, sertraline): may enhance sedative effects.
  • Antihistamines: can add to drowsiness and impair alertness.

Frequently Asked Questions

Morfeo contains the active ingredient Zaleplon and is prescribed for the short‑term treatment of sleep onset insomnia. It helps adult patients who have difficulty falling asleep to initiate sleep more quickly, typically for a limited period under medical supervision.

Zaleplon enhances the activity of the neurotransmitter GABA by binding to the benzodiazepine site on the GABA_A receptor complex. This positive allosteric modulation increases chloride ion flow into neurons, producing a calming effect that facilitates the onset of sleep without markedly altering the overall sleep structure.

The specific dose of Zaleplon is determined by the prescribing clinician based on the patient’s age, health status, and response to therapy. Dosage instructions are individualized and should be followed exactly as written on the prescription label.

The safety of Zaleplon during pregnancy and lactation has not been definitively established. It is classified as pregnancy category unknown, and clinicians generally avoid prescribing it to pregnant or nursing women unless the potential benefit outweighs potential risks.

To order Morfeo, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Zaleplon belongs to the Z‑drug class and is often compared with other non‑benzodiazepine hypnotics such as zolpidem and zaleplon’s older counterpart, benzodiazepines like temazepam. Z‑drugs typically have a shorter half‑life, leading to less next‑day residual sedation, whereas benzodiazepines may cause more prolonged sedation and higher dependence potential.

Morfeo tablets should be stored at ambient temperature, preferably below 25 °C. Keep them in the original packaging to protect from moisture and light, and keep out of reach of children. Do not use if the packaging is damaged or the tablets appear discoloured.

Morfeo is taken orally, usually with a full glass of water, shortly before the intended bedtime. It should be taken only when the patient can obtain a full night’s sleep (7–8 hours) and should not be combined with alcohol or other sedating substances.

Serious risks associated with Zaleplon include severe allergic reactions, complex sleep behaviours such as sleep‑walking or sleep‑driving, depression or suicidal thoughts, and respiratory depression when combined with other central nervous system depressants. Patients should seek immediate medical attention if any of these occur.

Morfeo is contraindicated in patients with known hypersensitivity to Zaleplon or any component of the formulation, those with severe hepatic impairment, and individuals who are currently using other CNS depressants such as benzodiazepines, opioids, or alcohol. It should also be avoided in patients with a history of complex sleep‑related behaviours.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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