Product image of Morfina Labesfal (Morphine Hydrochloride Trihydrate) supplied by GNH India

Morfina Labesfal

Active Ingredient:
Morphine Hydrochloride Trihydrate
Origin:
EU

Morfina Labesfal (Morphine Hydrochloride Trihydrate)

Morphine Hydrochloride Trihydrate, the active ingredient in Morfina Labesfal, is an opioid analgesic presented as an injection solution for intramuscular, intravenous, subcutaneous use. It treats moderate to severe acute pain, post‑operative pain and cancer‑related pain in adult patients.

GNH India supplies Morfina Labesfal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide.

Manufacturer / TM Owner

Labesfal Laboratorios Almiro, S.A.

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Indications & Clinical Uses

Morphine, an opioid analgesic, is used for pain management in several clinical settings.

  • Moderate to severe acute pain: provides rapid analgesia for short‑term severe pain episodes.
  • Post‑operative pain: reduces pain after surgical procedures to facilitate recovery.
  • Cancer‑related pain: helps control persistent pain associated with malignant disease.

How It Works

  • Morphine acts as a full agonist at mu‑opioid receptors in the central nervous system. Activation of these receptors inhibits the release of neurotransmitters involved in nociceptive transmission, decreases neuronal excitability, and raises the pain threshold, resulting in analgesia while also producing sedation and respiratory effects.

Side Effects

Morphine may cause a range of adverse reactions, varying from frequent to rare but serious.

Common Side Effects

  • Nausea: feeling of sickness or urge to vomit.
  • Constipation: reduced bowel movements.
  • Drowsiness: increased sleepiness or fatigue.
  • Itching: mild skin pruritus.
  • Dry mouth: reduced salivation.

Serious or Rare Side Effects

  • Severe respiratory depression: marked reduction in breathing that can be life‑threatening.
  • Hypotension: significant drop in blood pressure.
  • Allergic reactions: hives, swelling, or anaphylaxis.

Precautions & Warnings

When using Morfina Labesfal, clinicians should consider several safety measures.

  • Dose titration: adjust dose to individual response and tolerance.
  • Renal impairment: use with caution and monitor for accumulation.
  • Hepatic impairment: consider reduced dosing and close observation.
  • Concomitant CNS depressants: increased risk of respiratory depression.
  • Pregnancy: category C; weigh benefits against potential fetal risk.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Morphine interacts with several drug classes; awareness helps prevent adverse events.

Major Interactions (Avoid)

  • Other opioids: additive respiratory depression.
  • CNS depressants (e.g., benzodiazepines, barbiturates): heightened sedation and breathing suppression.
  • MAO inhibitors: risk of severe hypotension and serotonin syndrome.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inhibitors (e.g., erythromycin): may increase morphine plasma levels.
  • CYP3A4 inducers (e.g., rifampin): may reduce analgesic efficacy.
  • Diuretics: can enhance hypotensive effects.

Frequently Asked Questions

Morfina Labesfal is an injectable form of morphine hydrochloride used to manage moderate to severe acute pain, post‑operative pain, and cancer‑related pain. It provides rapid analgesia when administered intravenously, intramuscularly, or subcutaneously, helping patients achieve better comfort during short‑term or chronic painful conditions.

Morphine works by binding to mu‑opioid receptors in the brain, spinal cord and peripheral nervous system. This binding inhibits the release of pain‑transmitting neurotransmitters, reduces neuronal excitability, and raises the threshold for pain perception, resulting in effective analgesia while also producing sedation and respiratory effects.

The specific dose of Morfina Labesfal is determined by the prescribing clinician based on the patient’s age, weight, pain severity, prior opioid exposure, and clinical setting. Healthcare professionals calculate the appropriate amount and frequency to achieve adequate pain control while minimizing adverse effects.

Morphine is classified as Pregnancy Category C, indicating that risk to the fetus cannot be ruled out. It should only be used during pregnancy when the potential benefit justifies the potential risk. Morphine passes into breast milk; therefore, breastfeeding mothers should discuss alternatives with their healthcare provider.

To order Morfina Labesfal, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and necessary import documentation.

Morfina Labesfal (morphine) is a benchmark opioid with well‑established efficacy for severe pain. Compared with synthetic opioids such as fentanyl, morphine has a longer history of use, a broader therapeutic window, and is less lipid‑soluble, which influences onset and duration. Choice of agent depends on pain type, required speed of onset, and patient‑specific factors.

Morfina Labesfal should be stored refrigerated at 2‑8 °C, protected from light, and kept in its original packaging. Do not freeze or shake the vial. Before use, allow the solution to reach room temperature if required, and inspect for particulate matter or discoloration.

Morfina Labesfal is supplied as a sterile injection solution and can be given intravenously, intramuscularly, or subcutaneously. The route, volume and rate of administration are determined by the prescribing clinician, who may use a syringe, infusion pump or other approved device according to standard aseptic techniques.

The most serious risks include severe respiratory depression, profound hypotension, and the potential for dependence or addiction. Patients should be closely monitored for signs of breathing difficulty, low blood pressure, and unusual sedation, especially when initiating therapy or when combined with other central nervous system depressants.

Morfina Labesfal is contraindicated in individuals with known hypersensitivity to morphine or any component of the formulation, in patients with severe respiratory depression, acute asthma attacks, or paralytic ileus. Caution is also advised for patients with uncontrolled head injury or increased intracranial pressure.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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