Product image of Morfinesulfaat Retard Teva (Morphine Sulfate Pentahydrate) supplied by GNH India

Morfinesulfaat Retard Teva

Active Ingredient:
Morphine Sulfate Pentahydrate
Origin:
EU

Morfinesulfaat Retard Teva (Morphine Sulfate Pentahydrate)

Morphine sulfate pentahydrate, the active ingredient in Morfinesulfaat Retard Teva, is an opioid analgesic presented as a prolonged‑release oral formulation for oral use. It is employed to manage severe acute pain, chronic cancer pain and chronic non‑cancer pain in adult patients.
GNH India supplies Morfinesulfaat Retard Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva Nederland B.V.

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Indications & Clinical Uses

Morfinesulfaat Retard Teva is an opioid analgesic used to treat pain conditions that involve the mu‑opioid receptor pathway.

  • Severe acute pain: provides potent analgesia for intense postoperative or trauma‑related pain.
  • Chronic cancer pain: helps control persistent pain associated with malignant disease.
  • Chronic non‑cancer pain: offers long‑lasting relief for conditions such as severe osteoarthritis or neuropathic pain.

How It Works

  • Morphine sulfate pentahydrate acts as a full agonist at central mu‑opioid receptors. Binding to these G‑protein‑coupled receptors inhibits adenylate cyclase activity, reduces calcium influx, and increases potassium efflux, leading to decreased neuronal excitability and diminished transmission of nociceptive signals, thereby producing analgesia.

Side Effects

Common side effects are typically dose‑related and may affect tolerability.

Common Side Effects

  • Constipation: reduced gastrointestinal motility.
  • Nausea: upset stomach and possible vomiting.
  • Drowsiness: sedation and reduced alertness.
  • Dizziness: light‑headed sensation, especially on standing.
  • Dry mouth: decreased salivation.
  • Sweating: excessive perspiration.

Serious or Rare Side Effects

  • Respiratory depression: slowed or shallow breathing that can be life‑threatening.
  • Severe hypotension: marked drop in blood pressure.
  • Anaphylactic reaction: sudden, severe allergic response.
  • Adrenal insufficiency: impaired cortisol production.
  • Serotonin syndrome: when combined with serotonergic agents, causing agitation, hyperthermia, and neuromuscular abnormalities.

Precautions & Warnings

Before initiating therapy, clinicians should evaluate patient‑specific factors and monitor for adverse outcomes.

  • Assess pain severity: ensure opioid therapy is appropriate for the level of pain.
  • Monitor respiratory function: watch for signs of depression, especially after dose changes.
  • Evaluate for opioid dependence: screen for history of substance use disorder.
  • Adjust dose in renal/hepatic impairment: reduced clearance may increase toxicity risk.
  • Avoid concomitant CNS depressants: limit additive sedation or respiratory effects.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Morphine may interact with several drug classes, altering its safety or efficacy.

Major Interactions (Avoid)

  • Benzodiazepines or other CNS depressants: can cause profound sedation and respiratory depression.
  • Monoamine oxidase inhibitors (MAOIs): increase risk of serotonin syndrome.
  • Respiratory depressants (e.g., barbiturates): potentiate respiratory suppression.

Moderate Interactions (Monitor Closely):\n- CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): may raise morphine plasma levels.

  • Diuretics: can enhance hypotensive effects.
  • Antihistamines: may increase sedation.
  • Antidepressants (SSRIs, SNRIs): monitor for additive serotonergic effects.

Frequently Asked Questions

Morfinesulfaat Retard Teva contains morphine sulfate pentahydrate and is prescribed to manage severe acute pain, chronic cancer‑related pain, and chronic non‑cancer pain. It provides long‑acting analgesia through oral administration, helping patients achieve better pain control when other treatments are insufficient.

Morphine sulfate acts as a full agonist at mu‑opioid receptors in the central nervous system. By binding these receptors, it inhibits neuronal firing, reduces the release of excitatory neurotransmitters, and diminishes the perception of pain, resulting in effective analgesia.

The specific dose of Morfinesulfaat Retard Teva is determined by the prescribing clinician based on the individual’s pain severity, prior opioid exposure, renal and hepatic function, and other clinical factors. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety of morphine‑containing products during pregnancy or lactation is not fully established. Use is generally reserved for situations where the benefit outweighs potential risks to the fetus or infant. Healthcare providers should evaluate each case carefully and discuss alternatives when possible.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Morfinesulfaat Retard Teva offers a prolonged‑release oral formulation of morphine, providing steady plasma concentrations over an extended period. Compared with immediate‑release opioids, it reduces dosing frequency but requires careful titration and monitoring. Its efficacy is comparable to other strong opioids such as oxycodone or fentanyl when used appropriately.

Store the product at ambient temperature, preferably below 25 °C. Keep it in the original packaging, protect it from moisture, heat and direct sunlight, and ensure the container is tightly closed to maintain product stability.

Morfinesulfaat Retard Teva is taken orally, usually as whole tablets or capsules, without crushing or chewing, to preserve the extended‑release matrix. It should be swallowed with a full glass of water, and dosing intervals are set by the prescriber.

The most serious risks include respiratory depression, severe hypotension, profound sedation, and the potential for dependence or misuse. Patients should be monitored closely for signs of respiratory compromise, especially after dose initiation or escalation.

Morfinesulfaat Retard Teva is contraindicated in individuals with known hypersensitivity to morphine or any component of the formulation, those who have experienced severe respiratory depression, acute or severe asthma, or paralytic ileus. Caution is also advised for patients with significant renal or hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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