Morniflu Adulti (Morniflumate)

Morniflu Adulti, a fenamate NSAID, is used to manage inflammatory conditions affecting the musculoskeletal system.

• Rheumatoid arthritis: reduces joint inflammation and pain, improving mobility.
• Osteoarthritis: alleviates chronic joint discomfort and stiffness.
• Acute musculoskeletal pain: provides rapid relief of pain and swelling after injury or surgery.

• Morniflumate exerts its anti‑inflammatory action by non‑selectively inhibiting cyclooxygenase (COX‑1 and COX‑2) enzymes, which decreases the synthesis of prostaglandins involved in pain, fever and inflammation. The reduced prostaglandin levels lead to diminished vascular permeability and leukocyte infiltration at sites of tissue injury, thereby providing analgesic and anti‑edematous effects.

Morniflu Adulti may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

• Gastrointestinal discomfort: nausea, dyspepsia or abdominal pain.
• Headache: mild to moderate intensity.
• Dizziness: transient sensation of light‑headedness.
• Skin rash: mild erythema or pruritus.
• Diarrhoea: loose stools.

Serious or Rare Side Effects

• Gastrointestinal ulceration or bleeding.
• Hepatic dysfunction: elevated liver enzymes or hepatitis.
• Renal impairment: reduced kidney function or acute renal failure.
• Severe hypersensitivity reactions: anaphylaxis or Stevens‑Johnson syndrome.
• Cardiovascular events: increased risk of myocardial infarction or stroke.

When prescribing Morniflu Adulti, clinicians should consider several precautionary measures to minimise risk.

• Assess gastrointestinal risk: evaluate history of ulcers or bleeding before use.
• Monitor liver function: perform baseline and periodic liver enzyme tests.
• Evaluate renal function: check creatinine clearance, especially in elderly patients.
• Use the lowest effective dose: limit duration to the shortest period required for symptom control.
• Avoid in patients with known hypersensitivity to fenamates or other NSAIDs.
• Store at ambient temperature: keep in the original packaging, protect from moisture and direct heat.

Morniflu Adulti can interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): increased risk of serious bleeding.
• Other NSAIDs or corticosteroids: heightened gastrointestinal ulceration risk.
• Selective serotonin reuptake inhibitors (SSRIs): amplified bleeding tendency.

Moderate Interactions (Monitor Closely)

• ACE inhibitors or ARBs: may reduce renal perfusion, monitor kidney function.
• Diuretics: potential for reduced antihypertensive effect and renal impairment.
• Lithium: NSAIDs can increase lithium serum levels, require close monitoring.