Product image of Morphin 10 Retard (Morphine Sulfate) supplied by GNH India

Morphin 10 Retard

Active Ingredient:
Morphine Sulfate
Origin:
EU

Morphin 10 Retard (Morphine Sulfate)

Morphine sulfate, the active ingredient in Morphin 10 Retard, is an opioid analgesic presented as a 10 mg extended‑release oral tablet for oral use. It treats severe acute pain, cancer pain and post‑operative pain in adult patients.

GNH India supplies Morphin 10 Retard as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Aliud Pharma Gmbh

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Indications & Clinical Uses

  • Morphine sulfate is an opioid analgesic used to manage severe pain through central nervous system mu‑opioid receptor activation.
  • Severe acute pain: provides rapid relief of intense pain episodes.
  • Cancer pain: controls persistent pain associated with malignant disease.
  • Post‑operative pain: manages pain following surgical procedures.

How It Works

  • Morphine sulfate binds to and activates mu‑opioid receptors in the central nervous system, inhibiting the transmission of nociceptive signals and altering the perception of pain. This receptor activation reduces neuronal excitability, leading to analgesia, sedation, and decreased autonomic responses associated with severe pain.

Side Effects

Common Side Effects

  • Nausea
  • Constipation
  • Drowsiness
  • Dry mouth

Serious or Rare Side Effects

  • Respiratory depression
  • Severe hypotension
  • Allergic reactions, including anaphylaxis

Precautions & Warnings

Morphin 10 Retard requires careful clinical assessment and monitoring.

  • Assess pain severity before initiating therapy: ensure opioid indication is appropriate.
  • Monitor respiratory function: watch for signs of depression, especially after dose changes.
  • Evaluate for opioid dependence: screen patients with a history of substance use.
  • Adjust dose in renal or hepatic impairment: consider reduced clearance.
  • Avoid concurrent CNS depressants when possible: may increase sedation risk.
  • Store at ambient temperature: keep in original packaging, protect from moisture and light.

Avoid Interactions

Morphin 10 Retard may interact with several medicines; clinicians should review patient medication lists.

Major Interactions (Avoid)

  • Concomitant use with other opioids: additive respiratory depression.
  • CNS depressants (e.g., benzodiazepines, barbiturates): heightened sedation and respiratory risk.
  • MAO inhibitors: risk of severe hypotension and serotonin syndrome.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inhibitors (e.g., erythromycin): may increase morphine plasma levels.
  • CYP3A4 inducers (e.g., rifampin): may reduce analgesic effect.
  • Anticholinergic agents: can exacerbate constipation.

Frequently Asked Questions

Morphin 10 Retard is an extended‑release oral tablet containing morphine sulfate. It is prescribed to manage severe acute pain, cancer‑related pain, and post‑operative pain when a long‑acting opioid is required for continuous analgesia.

Morphine sulfate acts as a mu‑opioid receptor agonist in the central nervous system. By binding these receptors, it blocks transmission of pain signals, alters pain perception, and produces analgesia, sedation, and reduced autonomic responses.

The specific dose of Morphin 10 Retard is determined by the prescribing clinician based on the patient’s pain severity, prior opioid exposure, renal and hepatic function, and individual response. Dosage adjustments are made under medical supervision.

Safety of morphine sulfate in pregnancy or lactation has not been definitively established. It is generally avoided unless the potential benefit justifies the potential risk to the fetus or infant. Clinicians should assess risks and discuss alternatives with the patient.

To order Morphin 10 Retard, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Morphin 10 Retard provides extended‑release delivery of morphine sulfate, offering steadier plasma concentrations over 12‑24 hours compared with immediate‑release formulations. This can reduce dosing frequency and improve pain control for chronic severe pain, whereas short‑acting opioids may require multiple daily doses.

Store Morphin 10 Retard tablets at ambient temperature, below 25 °C, in the original container. Protect from moisture, direct sunlight and excessive heat to maintain tablet integrity and potency.

Morphin 10 Retard is taken orally, usually whole with water. The tablet should not be crushed, chewed, or broken, as this can release the entire dose at once and increase the risk of serious adverse effects.

The most serious risks include respiratory depression, severe hypotension, and allergic reactions such as anaphylaxis. Patients should be monitored closely for signs of these events, especially during dose initiation or when combined with other depressant drugs.

Morphin 10 Retard is contraindicated in patients with known hypersensitivity to morphine or other opioids, those who have experienced severe respiratory depression, acute or severe bronchial asthma, or paralytic ileus. It should also be avoided in individuals taking MAO inhibitors within the past 14 days.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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