Product image of Morphin 100 Retard (Morphine Sulfate) supplied by GNH India

Morphin 100 Retard

Active Ingredient:
Morphine Sulfate
Origin:
EU

Morphin 100 Retard (Morphine Sulfate)

Morphine sulfate, the active ingredient in Morphin 100 Retard, is an opioid analgesic presented as a 100 mg prolonged‑release tablet for oral use. It treats moderate to severe acute pain, post‑operative pain, cancer‑related pain and chronic severe pain when other analgesics are insufficient.

GNH India supplies Morphin 100 Retard as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide.

Manufacturer / TM Owner

Aliud Pharma Gmbh

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Indications & Clinical Uses

Morphin 100 Retard is an opioid analgesic used for conditions that require strong, sustained pain relief.

  • Moderate to severe acute pain: provides continuous analgesia for patients with intense short‑term pain.
  • Post‑operative pain: maintains pain control after surgical procedures when oral therapy is appropriate.
  • Cancer‑related pain: offers long‑acting relief for malignant disease‑associated discomfort.

How It Works

  • Morphine sulfate acts as a full agonist at central mu‑opioid receptors. Binding to these receptors inhibits the release of neurotransmitters involved in nociceptive transmission, reduces neuronal excitability, and alters the perception of pain. The result is analgesia accompanied by sedation, mediated through modulation of the ascending pain pathways and the limbic system.

Side Effects

Morphin 100 Retard may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea
  • Constipation
  • Drowsiness
  • Dizziness
  • Dry mouth
  • Sweating

Serious or Rare Side Effects

  • Respiratory depression
  • Severe hypotension
  • Adrenal insufficiency
  • Serotonin syndrome
  • Anaphylactic reaction
  • Opioid dependence or addiction

Precautions & Warnings

When prescribing or dispensing Morphin 100 Retard, consider the following safety measures.

  • Assess pain severity: ensure opioid therapy is clinically justified.
  • Evaluate respiratory function: monitor patients with compromised breathing.
  • Review substance‑use history: identify risk of misuse or dependence.
  • Adjust dose in renal or hepatic impairment: start low and titrate cautiously.
  • Monitor for excessive sedation or confusion: especially in elderly patients.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Morphin 100 Retard can interact with several drug classes; awareness helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Central nervous system depressants (e.g., benzodiazepines, barbiturates): may cause profound respiratory depression.
  • Monoamine oxidase inhibitors (MAOIs): increase risk of serotonin syndrome.
  • Potent CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): raise morphine plasma levels.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampin, carbamazepine): may reduce analgesic effect.
  • Other opioids or opioid‑containing products: risk of additive sedation.
  • Anticholinergic agents: may exacerbate constipation.
  • Diuretics: can enhance orthostatic hypotension.

Frequently Asked Questions

Morphin 100 Retard is a prolonged‑release oral formulation of morphine sulfate indicated for the management of moderate to severe acute pain, post‑operative pain, and cancer‑related pain when non‑opioid analgesics are insufficient. It provides sustained analgesia over an extended dosing interval, helping to maintain consistent pain control.

Morphine sulfate binds to mu‑opioid receptors in the central nervous system, acting as a full agonist. This interaction inhibits the release of excitatory neurotransmitters, reduces neuronal firing in pain pathways, and alters the perception of pain, resulting in analgesia and often sedation.

The appropriate dose of Morphin 100 Retard is individualized and determined by the prescribing clinician based on the patient’s pain severity, prior opioid exposure, renal and hepatic function, and overall clinical condition. Dosage adjustments are made to achieve effective pain relief while minimizing adverse effects.

Safety data for morphine sulfate in pregnancy and lactation are limited, and the drug is generally classified as contraindicated or to be used only when the potential benefit justifies the risk. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their healthcare provider.

To order Morphin 100 Retard, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Both morphine and oxycodone are strong opioid analgesics, but morphine has a longer history of use and is often available in a prolonged‑release formulation like Morphin 100 Retard. Oxycodone may have a slightly faster onset but can be associated with a higher incidence of certain gastrointestinal side effects. Choice depends on patient response, tolerability, and prescriber preference.

Morphin 100 Retard should be stored at ambient temperature, preferably below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and do not store in bathrooms or other humid environments.

Morphin 100 Retard is taken orally. The tablet should be swallowed whole with a full glass of water and not chewed, crushed, or broken, as this could release the entire dose at once and increase the risk of serious side effects.

The most serious risks include respiratory depression, severe hypotension, opioid dependence or addiction, and rare but life‑threatening allergic reactions such as anaphylaxis. Patients should be monitored closely for signs of shallow breathing, excessive sedation, or any unexpected allergic symptoms.

Morphin 100 Retard is contraindicated in patients with known hypersensitivity to morphine or any component of the formulation, those with severe respiratory insufficiency, acute or severe bronchial asthma, and patients who have taken monoamine oxidase inhibitors within the past 14 days. Caution is also advised in individuals with significant renal or hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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