Product image of Morphin 30 Retard (Morphine Sulfate) supplied by GNH India

Morphin 30 Retard

Active Ingredient:
Morphine Sulfate
Origin:
EU

Morphin 30 Retard (Morphine Sulfate)

Morphine sulfate, the active ingredient in Morphin 30 Retard, is an opioid analgesic presented as a prolonged‑release oral tablet for oral use. It is indicated for the management of moderate to severe pain in adult patients.
GNH India supplies Morphin 30 Retard as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Aliud Pharma Gmbh

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Indications & Clinical Uses

Morphin 30 Retard is an opioid analgesic that acts on the mu‑opioid receptor pathway to relieve pain.

  • Acute severe pain: provides rapid analgesia for postoperative or trauma‑related pain.
  • Cancer‑related pain: manages moderate to severe pain associated with malignant disease.
  • Chronic non‑cancer pain: offers sustained relief for long‑term severe pain conditions.

How It Works

  • Morphine sulfate binds selectively to mu‑opioid receptors in the central nervous system, inhibiting the release of excitatory neurotransmitters and altering pain perception. This receptor activation reduces neuronal excitability, producing analgesia and sedation while also affecting respiratory and gastrointestinal motility.

Side Effects

Morphin 30 Retard may cause a range of adverse reactions.

Common Side Effects

  • Constipation: reduced gastrointestinal motility leading to hard stools.
  • Nausea: feeling of queasiness or urge to vomit.
  • Drowsiness: sedation or increased sleepiness.
  • Dry mouth: reduced salivation causing oral dryness.

Serious or Rare Side Effects

  • Respiratory depression: slowed breathing that can be life‑threatening.
  • Severe hypotension: marked drop in blood pressure.
  • Dependence or addiction: risk of physical or psychological dependence with prolonged use.

Precautions & Warnings

When prescribing Morphin 30 Retard, clinicians should consider several safety measures.

  • Dose titration: start with the lowest effective dose and adjust gradually.
  • Concomitant CNS depressants: avoid or monitor use with alcohol, benzodiazepines, or other sedatives.
  • Renal or hepatic impairment: adjust dosing and monitor closely in patients with liver or kidney dysfunction.
  • History of respiratory disorders: use with caution in asthma, COPD, or sleep apnea.
  • Pregnancy and lactation: assess risk‑benefit; use only if clearly needed.
  • Store at ambient temperature: keep below 25°C in original packaging, protect from moisture and light.

Avoid Interactions

Morphin 30 Retard can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Other opioids: additive respiratory depression and sedation.
  • MAO inhibitors: risk of severe opioid toxicity.
  • CNS depressants (e.g., benzodiazepines, barbiturates): heightened sedation and respiratory depression.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): may increase morphine levels.
  • CYP3A4 inducers (e.g., rifampin, carbamazepine): may reduce efficacy.
  • Anticholinergics: may exacerbate constipation.
  • Diuretics: may enhance hypotensive effect.

Frequently Asked Questions

Morphin 30 Retard is a prolonged‑release formulation of morphine sulfate indicated for the treatment of moderate to severe pain, including postoperative pain, cancer‑related pain, and chronic non‑cancer pain that requires continuous opioid therapy.

Morphine sulfate acts as an agonist at mu‑opioid receptors in the brain and spinal cord. Activation of these receptors inhibits the release of excitatory neurotransmitters, decreasing neuronal firing and altering the perception of pain, while also producing sedation.

The dose of Morphin 30 Retard is individualized. A qualified prescriber determines the appropriate starting dose and titration schedule based on the patient’s pain severity, prior opioid exposure, renal and hepatic function, and overall clinical condition.

Safety data are limited. Morphine crosses the placenta and is excreted in breast milk, so it should be used during pregnancy or lactation only when the potential benefit justifies the potential risk to the fetus or infant. Consultation with a specialist is recommended.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Morphin 30 Retard provides a prolonged‑release profile, allowing once‑ or twice‑daily dosing, which can improve adherence compared with immediate‑release opioids that require more frequent dosing. Its potency is comparable to other strong opioids such as oxycodone, but conversion to equivalent doses must follow established opioid‑conversion guidelines.

Store Morphin 30 Retard at ambient temperature, preferably below 25 °C. Keep the tablets in the original container, protect them from moisture, heat and direct light, and ensure they are out of reach of children and unauthorized personnel.

Morphin 30 Retard is intended for oral administration. Swallow the tablet whole with a full glass of water; do not crush, chew, or split the tablet, as this can compromise the extended‑release mechanism and increase the risk of overdose.

The most serious risks include respiratory depression, severe hypotension, profound sedation, and the potential for physical dependence or addiction. Patients should be monitored closely for signs of respiratory compromise, especially during dose initiation or after dose adjustments.

Morphin 30 Retard is contraindicated in patients with known hypersensitivity to morphine or any component of the formulation, in those with significant respiratory depression, acute or severe bronchial asthma, or in patients who have taken monoamine oxidase inhibitors within the past 14 days.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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