Product image of Morphine (Chlorhydrate) Lavoisier (Morphine Hydrochloride) supplied by GNH India

Morphine (Chlorhydrate) Lavoisier

Active Ingredient:
Morphine Hydrochloride
Origin:
EU

Morphine (Chlorhydrate) Lavoisier (Morphine Hydrochloride)

Morphine, the active ingredient in Morphine (Chlorhydrate) Lavoisier, is an opioid analgesic presented as a sterile solution for epidural, intrathecal, and intravenous use. It provides potent analgesia for patients requiring intensive pain control in peri‑operative and palliative settings, and is employed to manage severe acute pain and chronic cancer‑related pain in adult patients.

GNH India supplies Morphine (Chlorhydrate) Lavoisier as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies, and clinics worldwide, adhering to stringent quality standards and regulatory requirements.

Manufacturer / TM Owner

Laboratoires Chaix Et Du Marais

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Indications & Clinical Uses

Morphine is an opioid analgesic used to treat pain conditions that involve the central nervous system.

  • Severe acute pain: provides rapid, strong analgesia for trauma or surgical patients.
  • Chronic cancer pain: offers sustained relief for malignant disease‑related discomfort.
  • Post‑operative pain: facilitates early mobilization by controlling surgical pain.
  • Palliative‑care pain: improves quality of life for patients with advanced illness.

How It Works

  • Morphine binds as an agonist to mu‑opioid receptors in the central nervous system, inhibiting the release of excitatory neurotransmitters and reducing neuronal excitability. This action decreases the perception of pain and alters the emotional response to painful stimuli, producing analgesia and sedation.

Side Effects

Morphine may cause a range of adverse reactions, from mild to life‑threatening.

Common Side Effects

  • Nausea: feeling of sickness often accompanied by vomiting.
  • Constipation: reduced bowel motility leading to hard stools.
  • Drowsiness: increased sleepiness or reduced alertness.
  • Dizziness: sensation of light‑headedness or unsteadiness.
  • Itching: pruritus, especially on the face or torso.
  • Dry mouth: reduced salivation causing discomfort.

Serious or Rare Side Effects

  • Respiratory depression: slowed or shallow breathing that can be fatal.
  • Severe hypotension: marked drop in blood pressure leading to fainting.
  • Anaphylaxis: rapid allergic reaction with airway compromise.
  • Dependence or addiction: development of physical or psychological reliance.
  • Seizures: rare occurrence of convulsive episodes.
  • Adrenal insufficiency: impaired cortisol production causing fatigue and weakness.

Precautions & Warnings

When using Morphine, clinicians should observe several safety measures.

  • Assess respiratory function: monitor for depression, especially after dose changes.
  • Evaluate renal and hepatic function: adjust use in patients with impairment.
  • Avoid use in patients with known hypersensitivity to morphine or its excipients.
  • Use caution in the elderly: increased sensitivity to central nervous system effects.
  • Pregnancy and lactation: consider risk‑benefit; use only if essential.
  • Store below 25°C: keep in the original container, protect from light and moisture.

Avoid Interactions

Morphine can interact with other medicines, altering its safety or effectiveness.

Major Interactions (Avoid)

  • CNS depressants (e.g., benzodiazepines, barbiturates): additive respiratory depression.
  • MAO inhibitors: risk of severe hypertension or serotonin syndrome.
  • SSRIs or SNRIs: potential for serotonin syndrome.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inhibitors (e.g., ketoconazole): increased morphine plasma concentrations.
  • CYP3A4 inducers (e.g., rifampin): reduced analgesic effect.
  • Diuretics: may enhance hypotensive response.

Frequently Asked Questions

Morphine (Chlorhydrate) Lavoisier is an injectable opioid analgesic indicated for the management of severe acute pain, chronic cancer‑related pain, postoperative pain, and pain in palliative‑care settings. It provides rapid and potent relief when administered via epidural, intrathecal, or intravenous routes.

Morphine acts as an agonist at mu‑opioid receptors in the brain and spinal cord. By activating these receptors, it inhibits the release of excitatory neurotransmitters, reduces neuronal firing, and alters the perception and emotional response to painful stimuli, resulting in analgesia and sedation.

The specific dose of Morphine (Chlorhydrate) Lavoisier is individualized and determined by the prescribing clinician based on the patient’s pain severity, prior opioid exposure, route of administration, and clinical condition. No fixed regimen is provided in product literature.

Safety in pregnancy and lactation has not been definitively established. Morphine crosses the placenta and may be excreted in breast milk, potentially causing respiratory depression in the newborn. Use only when the benefit to the mother outweighs potential risks to the fetus or infant.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Morphine is considered a benchmark opioid with a well‑characterized efficacy and safety profile. Compared with fentanyl, morphine has a longer onset but a shorter duration of action, making it suitable for titration in acute settings. Unlike oxycodone, morphine is typically administered intravenously or epidurally, offering precise control in hospital environments.

Store the sterile solution below 25 °C in its original container, protecting it from light and moisture. Do not freeze. Inspect the vial for particulate matter or discoloration before use, and discard any product that appears compromised.

Morphine (Chlorhydrate) Lavoisier is administered by a qualified healthcare professional via epidural, intrathecal, or intravenous injection. The route, infusion rate, and total dose are selected according to the clinical scenario and patient response, with continuous monitoring for efficacy and safety.

The most critical risks include respiratory depression, severe hypotension, anaphylactic reactions, and the potential for dependence or addiction. Prompt recognition of respiratory compromise and immediate medical intervention are essential to prevent life‑threatening outcomes.

Morphine should be avoided in patients with known hypersensitivity to morphine or any formulation component, in individuals with uncontrolled severe asthma, and in those taking monoamine oxidase inhibitors within 14 days. Caution is also advised for patients with significant respiratory, hepatic, or renal impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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