Product image of Morphine Unimedic (Morphine Hydrochloride Trihydrate) supplied by GNH India

Morphine Unimedic

Active Ingredient:
Morphine Hydrochloride Trihydrate
Origin:
EU

Morphine Unimedic (Morphine Hydrochloride Trihydrate)

Morphine Hydrochloride Trihydrate, the active ingredient in Morphine Unimedic, is an opioid analgesic presented as a sterile solution for epidural, intramuscular and intravenous use. It is employed to treat severe acute pain, chronic cancer pain and postoperative pain in adult patients.
GNH India supplies Morphine Unimedic as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide.

Manufacturer / TM Owner

Unimedic Pharma Ab

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Indications & Clinical Uses

Morphine Unimedic is an opioid analgesic used in the management of severe pain conditions.

  • Severe acute pain: provides rapid and potent analgesia for patients experiencing intense, short‑term pain.
  • Chronic cancer pain: helps control persistent pain associated with malignant disease when other therapies are insufficient.
  • Postoperative pain: offers effective relief after surgical procedures to facilitate recovery and mobilization.

How It Works

  • Morphine Hydrochloride Trihydrate acts as a full agonist at µ‑opioid receptors in the central nervous system. Binding to these G‑protein‑coupled receptors inhibits adenylate cyclase activity, reduces calcium influx, and increases potassium efflux, leading to decreased neuronal excitability and modulation of pain signal transmission, resulting in analgesia.

Side Effects

Common Side Effects

  • Nausea: feeling of sickness often accompanied by an urge to vomit.
  • Constipation: reduced bowel motility leading to hard stools.
  • Drowsiness: increased sleepiness or reduced alertness.
  • Itching: mild pruritus, especially around the face and neck.

Serious or Rare Side Effects

  • Respiratory depression: slowed or shallow breathing that can be life‑threatening.
  • Severe hypotension: marked drop in blood pressure causing dizziness or fainting.
  • Allergic reaction: rash, swelling, or anaphylaxis requiring immediate medical attention.

Precautions & Warnings

Morphine Unimedic requires careful clinical monitoring due to its potent opioid effects.

  • Assess pain level: determine baseline pain and adjust dose accordingly.
  • Monitor respiratory function: watch for signs of respiratory depression, especially after dose changes.
  • Evaluate renal and hepatic function: impaired metabolism may increase drug exposure.
  • Avoid use in patients with known hypersensitivity to morphine or other opioids.
  • Use the lowest effective dose: titrate to achieve analgesia while minimizing adverse effects.
  • Store at controlled room temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Morphine Unimedic can interact with several drug classes, altering its safety profile.

Major Interactions (Avoid)

  • Concomitant central nervous system depressants: may cause profound respiratory depression.
  • Monoamine oxidase inhibitors (MAOIs): risk of severe opioid toxicity.

Moderate Interactions (Monitor Closely)

  • Selective serotonin reuptake inhibitors (SSRIs): potential for serotonin syndrome.
  • Benzodiazepines: additive sedation and respiratory effects.
  • Diuretics: may enhance hypotensive response.

Frequently Asked Questions

Morphine Unimedic is an opioid analgesic indicated for the management of severe acute pain, chronic cancer‑related pain, and postoperative pain. It is administered by epidural, intramuscular or intravenous routes to provide rapid and effective pain relief in adult patients.

Morphine Hydrochloride binds to µ‑opioid receptors in the brain and spinal cord, activating inhibitory pathways that reduce the release of neurotransmitters involved in pain transmission. This results in decreased neuronal excitability and a marked reduction in the perception of pain.

The specific dose and dosing schedule for Morphine Unimedic are determined by the prescribing clinician based on the patient’s pain severity, prior opioid exposure, renal and hepatic function, and route of administration. No fixed regimen is provided here.

Safety data for Morphine Unimedic in pregnancy and lactation are limited. Opioids can cross the placenta and may be excreted in breast milk, potentially causing respiratory depression in the newborn. Use only if the potential benefit justifies the risk and under close medical supervision.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Morphine Unimedic is a prototypical µ‑opioid agonist with a well‑characterized efficacy and safety profile. Compared with newer synthetic opioids, it has a longer history of clinical use, predictable pharmacokinetics, and is often chosen for severe pain when rapid onset and reliable analgesia are needed.

Morphine Unimedic should be stored at controlled room temperature, below 25 °C, in its original packaging. Protect the product from moisture, direct sunlight, and physical damage. Do not freeze or expose to extreme temperatures.

The medication is supplied as a sterile solution for injection. It can be given epidurally, intramuscularly, or intravenously by a qualified healthcare professional, following aseptic technique and appropriate dosing calculations.

The most critical risks include respiratory depression, severe hypotension, and allergic reactions such as anaphylaxis. These events require immediate medical attention and may be life‑threatening if not recognized and treated promptly.

Morphine Unimedic is contraindicated in patients with known hypersensitivity to morphine or any component of the formulation, in those who have taken monoamine oxidase inhibitors within the past 14 days, and in individuals with significant respiratory compromise where opioid use could worsen ventilation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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