Morsadex (Dexketoprofen)

Dexketoprofen is an NSAID that reduces pain and inflammation through cyclo‑oxygenase inhibition. It is indicated for several acute pain settings:

• Postoperative pain: provides rapid analgesia after surgical procedures.
• Musculoskeletal pain: relieves pain associated with strains, sprains, and soft‑tissue injuries.
• Inflammatory conditions: reduces discomfort in acute inflammatory episodes such as tendonitis or bursitis.

• Dexketoprofen reversibly inhibits cyclo‑oxygenase (COX‑1 and COX‑2) enzymes, decreasing the synthesis of prostaglandins that mediate inflammation, pain, and fever. By limiting prostaglandin production at the site of tissue injury, it attenuates peripheral sensitisation and reduces the perception of pain.

Adverse reactions may occur with any NSAID injection. They are categorised by frequency and severity.

Common Side Effects

• Nausea: mild to moderate upset stomach.
• Headache: transient cranial discomfort.
• Dizziness: occasional light‑headedness.
• Injection‑site pain: local discomfort at the administration site.
• Dyspepsia: indigestion or heartburn.
• Diarrhoea: loose stools.

Serious or Rare Side Effects

• Gastrointestinal bleeding: potentially life‑threatening haemorrhage.
• Renal impairment: reduced kidney function or acute failure.
• Severe allergic reactions: anaphylaxis, angioedema, or urticaria.
• Stevens‑Johnson syndrome: rare severe skin reaction.
• Hepatotoxicity: liver enzyme elevations or hepatitis.
• Cardiovascular events: increased risk of thrombotic events in susceptible patients.

Before prescribing Dexketoprofen, clinicians should evaluate patient‑specific risk factors and monitor for adverse events.

• Renal function: assess baseline kidney status and avoid in severe impairment.
• Gastrointestinal risk: avoid in patients with active peptic ulcer disease or recent GI bleeding.
• Cardiovascular disease: use cautiously in patients with coronary artery disease or hypertension.
• Bleeding tendency: monitor closely if the patient is on anticoagulants or antiplatelet agents.
• Pregnancy and lactation: avoid unless the benefit clearly outweighs the risk.
• Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Dexketoprofen may interact with several drug classes, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): heightened risk of serious bleeding.
• Other NSAIDs or aspirin: additive gastrointestinal and renal toxicity.
• Corticosteroids: increased risk of GI ulceration and bleeding.

Moderate Interactions (Monitor Closely)

• ACE inhibitors or ARBs: may impair renal function, especially in volume‑depleted patients.
• Diuretics: potential for reduced renal perfusion and electrolyte disturbances.
• Lithium: NSAIDs can raise lithium levels, risking toxicity.
• Methotrexate: reduced clearance may lead to toxicity.