Product image of Motens (Lacidipine) supplied by GNH India

Motens

Active Ingredient:
Lacidipine
Origin:
EU

Motens (Lacidipine)

Lacidipine, the active ingredient in Motens, is a calcium channel blocker presented as a tablet for oral use. It lowers elevated blood pressure by relaxing vascular smooth muscle, and is prescribed for adult patients with hypertension.

GNH India supplies Motens as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable sourcing for regulated markets. Its global distribution network ensures timely delivery and compliance with local regulatory requirements.

Manufacturer / TM Owner

Glaxosmithkline Uk Limited

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Indications & Clinical Uses

  • Lacidipine is used to manage hypertension, a condition characterized by chronically elevated arterial pressure.
  • Hypertension: reduces systolic and diastolic blood pressure, improving cardiovascular risk profile.
  • Essential hypertension: provides sustained blood pressure control in patients without an identifiable secondary cause.
  • Isolated systolic hypertension: lowers systolic pressure especially in elderly patients.

How It Works

  • Lacidipine selectively blocks L-type calcium channels in vascular smooth‑muscle cells, inhibiting calcium influx that is necessary for muscle contraction. This vasodilatory effect reduces peripheral vascular resistance, leading to a decrease in arterial blood pressure without significantly affecting heart rate.

Side Effects

Lacidipine may cause a range of adverse reactions, which are categorized by frequency.

Common Side Effects

  • Headache: mild to moderate intensity, often transient.
  • Flushing: sensation of warmth and redness, usually temporary.
  • Peripheral edema: swelling of ankles or feet due to fluid accumulation.
  • Dizziness or light‑headedness, especially after standing.
  • Nausea: occasional stomach upset.

Serious or Rare Side Effects

  • Severe hypotension: marked drop in blood pressure causing fainting.
  • Angioedema: rapid swelling of face, lips, tongue, or airway.
  • Myocardial infarction: rare occurrence of heart attack.
  • Significant liver enzyme elevation.
  • Severe bradycardia or arrhythmia.
  • Allergic reactions such as rash or anaphylaxis.

Precautions & Warnings

  • When prescribing Lacidipine, clinicians should consider several safety measures.
  • Monitor blood pressure regularly: adjust therapy if target levels are not achieved.
  • Avoid abrupt discontinuation: tapering reduces rebound hypertension.
  • Caution in hepatic impairment: dose adjustment may be required.
  • Use cautiously in elderly patients: increased sensitivity to hypotensive effects.
  • Avoid concurrent strong CYP3A4 inhibitors: may raise drug concentrations.
  • Store at ambient temperature below 25°C: keep in the original container, protect from moisture and light.

Avoid Interactions

Lacidipine can interact with other medicines, influencing its efficacy or safety.

Major Interactions (Avoid)

  • Concomitant use with other antihypertensives (e.g., ACE inhibitors, ARBs) may cause additive hypotension.
  • Strong CYP3A4 inhibitors such as ketoconazole, itraconazole, or clarithromycin can increase Lacidipine plasma levels.
  • Grapefruit juice: may elevate drug concentration and risk of adverse effects.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampin, carbamazepine) may reduce therapeutic effect.
  • Diuretics: may enhance blood‑pressure‑lowering effect, requiring monitoring.
  • Beta‑blockers: combined use may affect heart rate and blood pressure.
  • NSAIDs: may attenuate antihypertensive response.

Frequently Asked Questions

Motens contains the active ingredient Lacidipine, which is prescribed to lower high blood pressure in adults. It belongs to the calcium channel blocker class and is indicated for the treatment of hypertension, helping to reduce the risk of cardiovascular complications associated with elevated arterial pressure.

Lacidipine selectively blocks L‑type calcium channels in the smooth muscle of blood vessels. By preventing calcium entry, it relaxes the vascular smooth muscle, causing vasodilation and a reduction in peripheral resistance, which leads to lower systolic and diastolic blood pressure.

The appropriate dose of Motens is determined by the prescribing healthcare professional based on the individual’s clinical condition, response to therapy, and any concomitant medications. Patients should follow the prescriber’s instructions and not adjust the dose without medical advice.

Safety data for Lacidipine in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss alternatives with their healthcare provider.

To request Motens, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Motens (Lacidipine) is a dihydropyridine calcium channel blocker, offering potent vasodilation with a relatively long half‑life. Compared with other classes such as ACE inhibitors or beta‑blockers, it primarily reduces peripheral resistance without significant effects on heart rate, making it suitable for patients who need strong blood‑pressure control and tolerate calcium‑channel‑blocker side‑effects.

Motens should be stored at ambient temperature below 25 °C, in its original packaging, protected from moisture and direct light. Keep the product out of reach of children and do not use it after the expiry date printed on the label.

Motens is taken orally, usually once daily, with or without food as directed by a healthcare professional. Swallow the tablet whole with a glass of water; do not crush, chew, or split the tablet unless specifically instructed by a prescriber.

The most serious risks include severe hypotension, which can cause fainting or shock, and rare but potentially life‑threatening reactions such as angioedema, myocardial infarction, or significant liver enzyme elevations. Patients should seek immediate medical attention if they experience swelling of the face or throat, chest pain, or sudden weakness.

Motens is contraindicated in patients with known hypersensitivity to Lacidipine or any other calcium channel blocker, and in those with severe aortic stenosis or unstable angina. Caution is also advised for individuals with severe hepatic impairment, as drug clearance may be reduced.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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