Motesin (Azelastine Hydrochloride, Fluticasone Propionate)

Azelastine hydrochloride is an H1‑receptor antagonist. By blocking histamine from binding to H1 receptors in the nasal mucosa, it prevents the cascade that leads to itching, sneezing, and vasodilation, thereby reducing the immediate allergic response.

Fluticasone propionate is a synthetic glucocorticoid. It penetrates nasal cells, binds to intracellular glucocorticoid receptors, and alters gene transcription to suppress the production of inflammatory cytokines, chemokines and adhesion molecules, reducing swelling and mucus formation.

The dosing regimen for Motesin is determined by the prescribing healthcare professional based on the patient’s age, severity of symptoms and clinical response. Patients should follow the specific instructions provided on the prescription label.

Safety in pregnancy and lactation has not been fully established. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using Motesin.

To order Motesin, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Motesin combines an antihistamine (azelastine) and a corticosteroid (fluticasone) in a single spray, offering both rapid symptom relief and anti‑inflammatory action. Single‑component sprays may provide either antihistamine or steroid effects alone, often requiring separate products for comparable control of allergic rhinitis.

Motesin should be stored at room temperature, below 25 °C. Keep the bottle in its original packaging, protect it from moisture and direct sunlight, and ensure the cap is tightly closed to maintain product stability.

Motesin is administered as a nasal spray. The recommended technique is to gently blow the nose, tilt the head slightly forward, insert the nozzle into one nostril while closing the other, and spray the prescribed number of sprays. The process is then repeated in the opposite nostril.

Serious risks include severe nosebleeds, allergic reactions such as anaphylaxis, adrenal suppression with prolonged use, vision changes (cataracts or glaucoma), and, in rare cases, growth suppression in children. Patients should seek immediate medical attention if they experience any of these events.

Motesin should not be used by individuals with a known hypersensitivity to azelastine, fluticasone, or any of the formulation excipients. It is also contraindicated in patients with recent nasal surgery or trauma until proper healing has occurred.