Product image of Motilex (Clebopride Hydrogen Maleate) supplied by GNH India

Motilex

Active Ingredient:
Clebopride Hydrogen Maleate
Origin:
EU

Motilex (Clebopride Hydrogen Maleate)

Clebopride hydrogen maleate, the active ingredient in Motilex, is a dopamine antagonist presented as an injectable solution for intramuscular and intravenous use. It is employed to treat nausea and vomiting, post‑operative nausea and vomiting, and gastrointestinal motility disorders in adult patients.
GNH India supplies Motilex as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Almirall, S.A.

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Motilex acts on dopaminergic pathways to control nausea, vomiting, and gastrointestinal motility.

  • Nausea and vomiting: reduces the frequency and severity of episodes.
  • Post‑operative nausea and vomiting: prevents or alleviates nausea after surgical procedures.
  • Gastrointestinal motility disorders: enhances gastric emptying and intestinal transit, improving digestive function.

How It Works

  • Clebopride hydrogen maleate selectively blocks dopamine D2 receptors in the chemoreceptor trigger zone and gastrointestinal tract. This antagonism diminishes the central emetic signal and stimulates smooth‑muscle activity, thereby accelerating gastric emptying and intestinal peristalsis while reducing nausea and vomiting.

Side Effects

Motilex may cause a range of adverse reactions.

Common Side Effects

  • Drowsiness: feeling unusually sleepy or fatigued.
  • Dizziness: light‑headed sensation, especially when standing quickly.
  • Dry mouth: reduced salivation leading to throat discomfort.
  • Constipation: decreased bowel movements.
  • Headache: mild to moderate cranial pain.
  • Hypotension: lower than normal blood pressure, may cause faintness.

Serious or Rare Side Effects

  • Extrapyramidal symptoms: involuntary muscle movements or rigidity.
  • Neuroleptic malignant syndrome: rare, life‑threatening reaction with fever and muscle rigidity.
  • Severe hypotension: marked drop in blood pressure requiring medical attention.
  • Cardiac arrhythmia: irregular heart rhythm.
  • Anaphylactic reaction: sudden severe allergic response.
  • Hepatic enzyme elevation: abnormal liver function tests.

Precautions & Warnings

When prescribing Motilex, clinicians should consider several safety aspects.

  • Renal impairment: assess kidney function and adjust therapy if necessary.
  • Cardiovascular disease: monitor blood pressure and heart rate closely.
  • Elderly patients: use with caution due to increased fall risk from dizziness.
  • Concomitant CNS depressants: may potentiate sedation and respiratory depression.
  • Pregnancy and lactation: safety not established; avoid unless benefits outweigh risks.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Motilex can interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): risk of hypertensive crisis.
  • Strong dopamine antagonists (e.g., typical antipsychotics): additive extrapyramidal effects.

Moderate Interactions (Monitor Closely)

  • Antihypertensive agents: may enhance hypotensive response.
  • Sedatives or CNS depressants: increased drowsiness and respiratory depression.
  • Serotonergic drugs (e.g., SSRIs, triptans): potential for serotonin syndrome.

Frequently Asked Questions

Motilex is an injectable medication containing Clebopride hydrogen maleate. It is used to manage nausea and vomiting, including post‑operative nausea, and to improve gastrointestinal motility in conditions where gastric emptying is delayed.

Clebopride hydrogen maleate blocks dopamine D2 receptors in the brain’s chemoreceptor trigger zone and in the gastrointestinal tract. This dual action reduces the central stimulus for vomiting and stimulates smooth‑muscle activity, promoting faster gastric emptying and intestinal movement.

The specific dose and administration schedule of Motilex are determined by the prescribing clinician based on the patient’s condition, severity of symptoms, and clinical response. Dosage details are provided in the product’s prescribing information.

Safety data for Motilex in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision should be made by a qualified healthcare professional.

To order Motilex, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and required import documentation.

Motilex belongs to the dopamine antagonist class, differing from serotonin‑type antiemetics such as ondansetron. While both reduce nausea, dopamine antagonists also enhance gastrointestinal motility, making Motilex particularly useful when delayed gastric emptying is a concern.

Motilex should be stored refrigerated at 2‑8 °C, protected from light, and must not be frozen or shaken. Keep the vial in its original packaging until use to maintain stability and sterility.

Motilex is supplied as an injectable solution and can be given either intramuscularly or intravenously by a qualified healthcare professional. The route and rate of administration are determined by the prescriber according to the clinical situation.

Serious risks include extrapyramidal symptoms, neuroleptic malignant syndrome, severe hypotension, cardiac arrhythmias, and rare allergic reactions such as anaphylaxis. Patients should be monitored for these events, especially during the initial phases of therapy.

Motilex is contraindicated in patients with known hypersensitivity to Clebopride or any component of the formulation. Caution is also advised for individuals with severe cardiovascular disease, uncontrolled hypertension, or those taking interacting medications listed under major interactions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Clebopride Hydrogen Maleate

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT