Product image of Motilium (Domperidone) supplied by GNH India

Motilium

Active Ingredient:
Domperidone
Origin:
EU

Motilium (Domperidone)

Domperidone, the active ingredient in Motilium, is a dopamine D2 receptor antagonist presented as an oral tablet for oral use. It is used to relieve nausea, vomiting and to improve gastric motility in conditions such as gastroparesis and functional dyspepsia.
GNH India supplies Motilium as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Janssen-Cilag

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Motilium acts on the gastrointestinal tract and the central vomiting centre to reduce symptoms of nausea and improve motility.

  • Nausea: reduces the sensation of nausea and the urge to vomit.
  • Vomiting: helps prevent episodes of vomiting associated with various triggers.
  • Gastroparesis: enhances gastric emptying in patients with delayed stomach emptying.
  • Functional dyspepsia: alleviates upper abdominal discomfort and early satiety.
  • Gastroesophageal reflux: supports reduction of reflux symptoms by improving gastric clearance.

How It Works

  • Domperidone blocks peripheral dopamine D2 receptors located in the chemoreceptor trigger zone and the gastrointestinal tract. This antagonism prevents dopamine‑mediated inhibition of gastrointestinal motility, thereby accelerating gastric emptying and transit. In the central nervous system, peripheral blockade reduces the stimulation of the vomiting centre, providing antiemetic effects without significant central dopamine antagonism.

Side Effects

Domperidone is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Dry mouth: reduced salivary flow causing a dry sensation.
  • Headache: mild to moderate head pain.
  • Abdominal cramps: discomfort or cramping in the stomach area.
  • Diarrhoea: loose stools occurring occasionally.
  • Dizziness: sensation of light‑headedness or unsteadiness.

Serious or Rare Side Effects

  • Cardiac arrhythmia: irregular heart rhythm, potentially serious.
  • Extrapyramidal symptoms: rare movement disorders such as tremor.
  • Hyperprolactinaemia: elevated prolactin levels causing galactorrhoea.
  • Allergic reaction: rash, itching, swelling or difficulty breathing.

Precautions & Warnings

Before prescribing Domperidone, consider patient‑specific factors and safety measures.

  • Cardiac risk assessment: evaluate history of arrhythmia or prolonged QT interval.
  • Liver function: monitor in patients with hepatic impairment.
  • Drug‑induced prolactin elevation: be aware of potential hormonal effects.
  • Pregnancy and lactation: use only if clearly needed after risk‑benefit analysis.
  • Elderly patients: start with the lowest effective dose and monitor closely.
  • Store at ambient temperature: keep below 25 °C, in the original packaging, protected from moisture.

Avoid Interactions

Domperidone may interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): increase domperidone plasma levels, raising cardiac risk.
  • QT‑prolonging agents (e.g., quinidine, haloperidol): additive effect on cardiac repolarisation.

Moderate Interactions (Monitor Closely):\n- Anticholinergic drugs: may enhance dry‑mouth and constipation.

  • Antiparkinsonian agents: possible reduction of therapeutic effect.
  • Other dopamine antagonists: increased risk of extrapyramidal symptoms.

Frequently Asked Questions

Motilium (domperidone) is prescribed to manage nausea and vomiting, to treat gastroparesis by enhancing stomach emptying, and to relieve symptoms of functional dyspepsia and gastro‑oesophageal reflux. It works by increasing gastrointestinal motility and reducing the stimulus to the vomiting centre.

Domperidone blocks peripheral dopamine D2 receptors in the gastrointestinal tract and the chemoreceptor trigger zone. This antagonism lifts dopamine‑mediated inhibition of gut motility, speeding gastric emptying, and reduces signals that trigger the vomiting reflex, providing anti‑emetic and pro‑kinetic effects.

The appropriate dose of Motilium is determined by the prescribing clinician based on the patient’s condition, age, renal and hepatic function, and other individual factors. Dosage instructions are provided on the prescription label and should be followed exactly as directed by a healthcare professional.

Domperidone should be used in pregnancy or while breastfeeding only if the potential benefit justifies any potential risk to the fetus or infant. The safety profile in these populations is not fully established, so clinicians must evaluate each case individually and discuss possible risks with the patient.

To order Motilium, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with centrally acting anti‑emetics such as metoclopramide, domperidone has limited penetration of the blood‑brain barrier, which reduces the risk of central side effects like sedation or extrapyramidal symptoms. However, both agents share similar pro‑kinetic actions, and choice depends on the clinical scenario and safety considerations.

Motilium should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original container, protect them from moisture and direct sunlight, and ensure they are out of reach of children.

Motilium is taken orally, usually with a glass of water. It can be taken with or without food, but patients should follow the specific instructions provided by their prescriber regarding timing relative to meals.

The most serious risks include cardiac arrhythmias, especially in patients taking other QT‑prolonging drugs or with existing heart conditions, and rare cases of extrapyramidal symptoms. Patients should be monitored for any signs of irregular heartbeat, dizziness, or movement disorders and seek medical attention promptly if they occur.

Motilium is contraindicated in individuals with known hypersensitivity to domperidone, those with existing QT prolongation or significant cardiac arrhythmias, and patients taking strong CYP3A4 inhibitors. It should also be avoided in patients with severe hepatic impairment unless specifically advised by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Domperidone

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT