Product image of Motilium (Domperidone) supplied by GNH India

Motilium

Active Ingredient:
Domperidone
Origin:
EU

Motilium (Domperidone)

Domperidone, the active ingredient in Motilium, is a dopamine D2 receptor antagonist presented as an oral tablet for oral use. It is employed to alleviate nausea, vomiting, and to improve gastrointestinal motility in adults and functional dyspepsia symptoms in appropriate patients under medical supervision.

GNH India supplies Motilium as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. Our global distribution network ensures consistent quality and regulatory compliance across all markets, enabling reliable access for healthcare providers through validated supply chain processes and timely delivery.

Manufacturer / TM Owner

Jntl Consumer Health I (Ireland) Limited

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Indications & Clinical Uses

Domperidone acts on the gastrointestinal tract and the chemoreceptor trigger zone to control nausea and improve motility.

  • Nausea: reduces episodes of nausea associated with various causes, including chemotherapy and postoperative states.
  • Vomiting: decreases the frequency and intensity of vomiting in acute and chronic settings.
  • Gastroparesis: enhances gastric emptying and relieves symptoms of delayed stomach emptying.
  • Functional dyspepsia: alleviates upper abdominal discomfort and early satiety.
  • Gastroesophageal reflux: reduces reflux episodes by improving lower esophageal sphincter tone.

How It Works

  • Domperidone exerts its effect by selectively antagonizing peripheral dopamine D2 receptors located in the chemoreceptor trigger zone and the gastrointestinal smooth muscle. By blocking dopamine‑mediated inhibition, it increases the release of acetylcholine, which stimulates gastric motility and accelerates gastric emptying. This mechanism also contributes to improved coordination of intestinal peristalsis.

Side Effects

Domperidone may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Dry mouth: reduced salivation leading to throat discomfort.
  • Headache: mild to moderate intensity.
  • Abdominal cramps: intermittent stomach pain.
  • Dizziness: sensation of light‑headedness.
  • Constipation: decreased bowel movements.
  • Diarrhoea: loose stools.

Serious or Rare Side Effects

  • Cardiac arrhythmia: irregular heart rhythm, including QT prolongation.
  • Extrapyramidal symptoms: muscle rigidity or tremor.
  • Severe allergic reaction: rash, swelling, or anaphylaxis.
  • Hyperprolactinemia: elevated prolactin causing galactorrhoea.
  • Galactorrhoea: unexpected milk secretion.
  • Liver enzyme elevation: signs of hepatic stress.

Precautions & Warnings

Before prescribing domperidone, clinicians should consider several safety precautions to minimize risk.

  • Assess cardiac risk: evaluate QT interval and avoid use in patients with known arrhythmias.
  • Review concomitant medications: avoid combination with other QT‑prolonging agents.
  • Monitor hepatic function: adjust use in patients with liver impairment.
  • Caution in electrolyte imbalance: correct potassium or magnesium disturbances before treatment.
  • Store at ambient temperature: keep in the original pack, protect from moisture and heat.

Avoid Interactions

Domperidone interacts with several drug classes, requiring attention to avoid adverse effects or reduced efficacy.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): increase domperidone plasma levels.
  • Other QT‑prolonging drugs (e.g., quinidine, sotalol): additive risk of cardiac arrhythmia.
  • Antifungal agents (e.g., itraconazole): may elevate domperidone concentrations.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampicin): may lower domperidone effectiveness.
  • Anticholinergic agents: combined anticholinergic burden may affect gastrointestinal motility.
  • Other antiemetics (e.g., metoclopramide): overlapping mechanisms may increase side‑effect risk.

Frequently Asked Questions

Motilium contains domperidone and is used to treat nausea and vomiting, to improve gastric emptying in gastroparesis, and to relieve symptoms of functional dyspepsia and gastro‑oesophageal reflux. It is prescribed for adults when these conditions affect quality of life.

Domperidone works by blocking dopamine D2 receptors outside the brain, mainly in the chemoreceptor trigger zone and the gastrointestinal tract. This blockade lifts dopamine‑induced inhibition, increasing acetylcholine release, which stimulates smooth‑muscle activity and speeds gastric emptying while providing anti‑emetic effects.

The appropriate dose of Motilium is determined by the prescribing clinician based on the patient’s condition, age, and renal or hepatic function. Dosage may vary, and the prescriber will provide specific instructions that should be followed exactly as written.

Safety data for domperidone in pregnancy and lactation are limited. It should only be used when the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To order Motilium, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Both domperidone (Motilium) and metoclopramide are pro‑kinetic agents, but domperidone has limited ability to cross the blood‑brain barrier, resulting in fewer central nervous system side effects such as extrapyramidal reactions. Metoclopramide may be more effective for certain types of nausea but carries a higher risk of central side effects.

Motilium tablets should be stored at ambient temperature, below 25 °C, in the original packaging to protect them from moisture and light. Keep the product out of reach of children and do not use it after the expiry date printed on the label.

Motilium is taken orally, usually with a glass of water. It can be taken with or without food, but the prescriber may advise a specific timing relative to meals to optimise absorption and therapeutic effect.

Serious risks include cardiac arrhythmias such as QT‑interval prolongation, which can lead to potentially life‑threatening ventricular tachycardia, and rare extrapyramidal reactions. Patients with known heart disease, electrolyte disturbances, or who are taking other QT‑prolonging drugs should be monitored closely.

Motilium should be avoided in patients with known prolonged QT interval, severe cardiac disease, significant hepatic impairment, or those taking strong CYP3A4 inhibitors. It is also contraindicated in individuals with a history of hypersensitivity to domperidone or any of the tablet’s excipients.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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