Product image of Motilium (Domperidone) supplied by GNH India

Motilium

Active Ingredient:
Domperidone
Origin:
EU

Motilium (Domperidone)

Domperidone, the active ingredient in Motilium, is a dopamine D2 receptor antagonist presented as an oral dosage form for oral use. It is used to relieve nausea, vomiting, gastroparesis and functional dyspepsia in adult patients.
GNH India supplies Motilium as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Kenvue Belgium Nv

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Indications & Clinical Uses

Motilium acts on the gastrointestinal motility pathway and is indicated for several digestive disorders.

  • Nausea and vomiting: reduces episodes of acute and chronic nausea and vomiting.
  • Gastroparesis: improves gastric emptying and alleviates related symptoms.
  • Functional dyspepsia: relieves upper abdominal discomfort and early satiety.

How It Works

  • Domperidone exerts its effect by selectively antagonising peripheral dopamine D2 receptors in the chemoreceptor trigger zone and gastrointestinal tract. This blockade enhances the release of acetylcholine, promoting gastric motility and accelerating gastric emptying, while also providing an anti‑emetic effect by reducing dopaminergic stimulation of the vomiting centre.

Side Effects

Domperidone is generally well tolerated, but several adverse reactions have been reported.

Common Side Effects

  • Dry mouth: reduced salivary flow causing throat discomfort.
  • Headache: mild to moderate intensity.
  • Abdominal cramps: intermittent stomach discomfort.
  • Dizziness: transient light‑headedness.
  • Diarrhoea: loose stools occurring occasionally.
  • Constipation: reduced bowel movements.

Serious or Rare Side Effects

  • Cardiac arrhythmia: QT interval prolongation leading to potential ventricular tachycardia.
  • Severe allergic reactions: rash, itching, swelling, or anaphylaxis.
  • Extrapyramidal symptoms: involuntary muscle movements.
  • Hyperprolactinaemia: elevated prolactin causing galactorrhoea.
  • Neuroleptic malignant syndrome: rare but life‑threatening condition.
  • Hepatic dysfunction: abnormal liver enzymes.

Precautions & Warnings

Before prescribing Domperidone, clinicians should consider several safety aspects.

  • Cardiac risk assessment: evaluate history of arrhythmia or prolonged QT interval.
  • Concomitant QT‑prolonging drugs: avoid or monitor closely when used together.
  • Electrolyte monitoring: correct hypokalaemia or hypomagnesaemia.
  • Hepatic impairment: use with caution in patients with liver dysfunction.
  • Hypersensitivity: discontinue if allergic reactions occur.
  • Store at below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Domperidone may interact with other medicines, requiring attention to the interaction level.

Major Interactions (Avoid)

  • Antiarrhythmic agents (e.g., quinidine): increase risk of cardiac arrhythmias.
  • Macrolide antibiotics (e.g., erythromycin): potentiate QT prolongation.
  • Ketoconazole: strong CYP3A4 inhibition raising domperidone levels.
  • HIV protease inhibitors: elevate plasma concentrations.
  • Other QT‑prolonging drugs: additive effect on cardiac conduction.

Moderate Interactions (Monitor Closely):\n- CYP3A4 inhibitors (e.g., fluconazole): may modestly increase exposure.

  • Anticholinergic agents: could enhance gastrointestinal side effects.
  • Other dopamine antagonists: potential additive central effects.

Frequently Asked Questions

Motilium (domperidone) is prescribed to manage nausea and vomiting, to improve gastric emptying in gastroparesis, and to relieve symptoms of functional dyspepsia such as early satiety and upper abdominal discomfort.

Domperidone blocks peripheral dopamine D2 receptors in the chemoreceptor trigger zone and the gastrointestinal tract. This action increases acetylcholine release, enhancing gastrointestinal motility and accelerating gastric emptying while also reducing dopaminergic stimulation of the vomiting centre.

The appropriate dose of Motilium is determined by the prescribing healthcare professional based on the patient’s condition, age, renal and hepatic function, and other individual factors. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for domperidone in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and necessary import documentation.

Compared with other anti‑emetics such as metoclopramide, domperidone has limited central nervous system penetration, resulting in a lower risk of extrapyramidal side effects. However, both agents share the potential for QT‑interval prolongation, so cardiac risk assessment is essential for either medication.

Motilium should be stored at temperatures below 25 °C, in its original packaging, and protected from moisture and direct sunlight. Keeping the product in a dry, cool place helps maintain its stability and potency.

Motilium is taken orally, usually with a glass of water. The tablet should be swallowed whole and not crushed or chewed, unless the prescriber provides specific instructions for a different dosage form.

The most serious risks include cardiac arrhythmias due to QT‑interval prolongation, severe allergic reactions, and rare extrapyramidal symptoms. Patients with known heart disease, electrolyte disturbances, or those taking other QT‑prolonging drugs should be monitored closely.

Motilium should be avoided in patients with known hypersensitivity to domperidone, those with a history of ventricular arrhythmias or prolonged QT interval, and individuals taking strong CYP3A4 inhibitors or other medications that significantly increase the risk of cardiac events.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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