Product image of Motrim (Trimethoprim) supplied by GNH India

Motrim

Active Ingredient:
Trimethoprim
Origin:
EU

Motrim (Trimethoprim)

Trimethoprim, the active ingredient in Motrim, is a dihydrofolate reductase inhibitor presented as a tablet for oral use. It treats urinary tract infections, including acute uncomplicated cystitis, in adult patients.

GNH India supplies Motrim as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

G.L. Pharma Gmbh

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Indications & Clinical Uses

Motrim is an antibacterial agent used to treat infections of the urinary tract and related conditions.

  • Urinary tract infections: eradicates susceptible bacteria and relieves urinary symptoms.
  • Acute uncomplicated cystitis: provides bacterial clearance and rapid symptom resolution.
  • Lower urinary tract infections (e.g., urethritis): reduces bacterial load and prevents progression.

How It Works

  • Trimethoprim inhibits bacterial dihydrofolate reductase, an enzyme required for the conversion of dihydrofolic acid to tetrahydrofolic acid. This blockade impairs folic acid synthesis, which is essential for bacterial DNA replication and cell division, leading to bacteriostatic activity against susceptible organisms.

Side Effects

Common side effects are generally mild and reversible.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Vomiting: occasional emesis.
  • Loss of appetite: reduced desire to eat.
  • Rash: mild skin erythema.
  • Diarrhea: loose stools.
  • Headache: transient head discomfort.

Serious or Rare Side Effects

  • Stevens‑Johnson syndrome: severe skin reaction requiring immediate medical attention.
  • Agranulocytosis or aplastic anemia: marked reduction in blood cell production.
  • Elevated liver enzymes: signs of hepatic stress.
  • Renal toxicity: impaired kidney function.
  • Severe allergic reactions: anaphylaxis or angioedema.
  • Hemolytic anemia in G6PD deficiency: destruction of red blood cells.

Precautions & Warnings

Before prescribing Motrim, clinicians should consider patient‑specific factors and monitor for adverse events.

  • Renal function: assess kidney status and adjust dose if necessary.
  • Hypersensitivity: discontinue if rash, pruritus, or systemic allergic signs develop.
  • Folate deficiency: monitor patients with low folate levels, especially those on long‑term therapy.
  • Pregnancy: use only if the potential benefit justifies the potential risk.
  • Known allergy to trimethoprim: avoid use.
  • Store at below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Trimethoprim may interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Warfarin: increased anticoagulant effect, risk of bleeding.
  • Methotrexate: heightened toxicity due to additive folate antagonism.
  • Phenytoin: accelerated clearance of trimethoprim, reducing effectiveness.
  • Trimethoprim‑sulfamethoxazole: duplicate therapy, unnecessary exposure.

Moderate Interactions (Monitor Closely)

  • NSAIDs: potential for reduced renal perfusion.
  • ACE inhibitors or ARBs: increased risk of hyperkalemia.
  • Loop or thiazide diuretics: electrolyte disturbances may be amplified.
  • Oral contraceptives: possible reduction in contraceptive efficacy.
  • Allopurinol: may increase risk of rash.

Frequently Asked Questions

Motrim, whose active ingredient is trimethoprim, is prescribed for bacterial urinary tract infections, including acute uncomplicated cystitis and other lower urinary tract infections caused by susceptible organisms.

Trimethoprim blocks bacterial dihydrofolate reductase, preventing the synthesis of tetrahydrofolic acid needed for DNA production. This inhibition stops bacterial replication, providing a bacteriostatic effect against susceptible pathogens.

The specific dose of Motrim is determined by the prescribing clinician based on the infection type, severity, patient age, renal function, and local resistance patterns. Patients should follow the prescriber’s instructions exactly.

Trimethoprim’s safety in pregnancy and lactation is not fully established. It should be used only when clearly needed and after a risk‑benefit assessment by the healthcare provider. Breastfeeding mothers should consult their physician before use.

To order Motrim, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Motrim (trimethoprim) is a folate‑antagonist antibiotic that offers targeted activity against many common urinary pathogens. Compared with broad‑spectrum agents such as fluoroquinolones, it has a narrower spectrum, lower risk of promoting resistance, and fewer drug‑interaction concerns, but susceptibility testing is essential.

Motrim tablets should be stored at temperatures below 25 °C, in the original packaging, and protected from moisture and direct sunlight to maintain potency throughout their shelf life.

Motrim is taken orally, usually with a full glass of water. The tablet should be swallowed whole and not chewed or crushed unless specifically instructed by a healthcare professional.

Serious risks include severe skin reactions such as Stevens‑Johnson syndrome, blood dyscrasias like agranulocytosis or aplastic anemia, significant liver enzyme elevations, renal toxicity, and hemolytic anemia in patients with G6PD deficiency. Immediate medical attention is required if any of these occur.

Motrim should be avoided in individuals with a known hypersensitivity to trimethoprim, those with severe renal impairment without dose adjustment, patients with folate deficiency unless supplemented, and anyone for whom the risk outweighs the benefit as determined by their clinician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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