Product image of Motufe (Fluticasone Furoate) supplied by GNH India

Motufe

Active Ingredient:
Fluticasone Furoate
Origin:
EU

Motufe (Fluticasone Furoate)

Fluticasone furoate, the active ingredient in Motufe, is a corticosteroid presented as a nasal spray for nasal use. It treats allergic rhinitis and seasonal allergic rhinitis in adults and children.
GNH India supplies Motufe as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Substipharm

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Indications & Clinical Uses

Motufe, a nasal corticosteroid, is used to manage inflammatory conditions of the nasal passages.

  • Allergic rhinitis: reduces nasal congestion, sneezing, itching and rhinorrhea.
  • Seasonal allergic rhinitis: provides symptom relief during pollen or mold seasons.
  • Hay fever: improves nasal airflow and diminishes inflammatory response.

How It Works

  • Fluticasone furoate acts as an agonist of the glucocorticoid receptor in nasal mucosal cells, leading to transcriptional repression of pro‑inflammatory cytokines, chemokines, and adhesion molecules. This anti‑inflammatory activity reduces edema, mucus production, and cellular infiltration, thereby alleviating nasal symptoms associated with allergic inflammation.

Side Effects

Adverse reactions may occur with any nasal corticosteroid.

Common Side Effects

  • Nasal irritation or burning sensation
  • Headache
  • Epistaxis (nosebleed)
  • Altered taste or bitter aftertaste
  • Throat irritation or dryness
  • Cough

Serious or Rare Side Effects

  • Nasal septal perforation
  • Severe allergic reaction (anaphylaxis)
  • Vision changes such as cataracts or glaucoma
  • Adrenal suppression with prolonged high‑dose use
  • Opportunistic fungal infection of the nasal passages

Precautions & Warnings

Before initiating therapy, consider the following safety measures.

  • Assess for active nasal infection: avoid use until infection resolves.
  • Avoid in patients with known hypersensitivity to fluticasone or other corticosteroids.
  • Use the lowest effective dose: follow prescriber guidance.
  • Do not exceed recommended treatment duration without medical review.
  • Monitor for signs of adrenal insufficiency during long‑term therapy.
  • Store at room temperature: keep in the original packaging, protect from moisture and heat.

Avoid Interactions

Fluticasone furoate may interact with other medicines; review the following categories.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase systemic corticosteroid exposure.
  • Live vaccines: systemic immunosuppression can reduce vaccine efficacy.

Moderate Interactions (Monitor Closely)

  • Concurrent intranasal medications: may increase local irritation.
  • Systemic corticosteroids: additive anti‑inflammatory effects may raise risk of systemic side effects.
  • Antifungal azoles (e.g., fluconazole): may modestly raise fluticasone levels.

Frequently Asked Questions

Motufe is indicated for the relief of symptoms associated with allergic rhinitis and seasonal allergic rhinitis. It helps reduce nasal congestion, sneezing, itching, and runny nose caused by allergic inflammation of the nasal passages.

Fluticasone furoate binds to glucocorticoid receptors in the nasal mucosa, suppressing the transcription of inflammatory genes. This reduces the release of cytokines, chemokines, and other mediators that cause swelling, mucus production, and irritation, thereby improving nasal airflow.

The prescribed dose of Motufe is determined by the treating healthcare professional based on the patient’s age, severity of symptoms, and response to therapy. Patients should follow the specific instructions provided by their prescriber.

Safety data for fluticasone furoate in pregnancy and lactation are limited. Healthcare providers should weigh the potential benefits against any possible risks before prescribing Motufe to pregnant or nursing individuals.

To request Motufe, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Motufe contains fluticasone furoate, which has a high affinity for the glucocorticoid receptor and a long residence time in nasal tissues, allowing once‑daily dosing. Compared with older agents such as fluticasone propionate, it may offer similar efficacy with a convenient dosing schedule.

Motufe should be stored at room temperature, below 25 °C. Keep the spray in its original container, protect it from moisture and direct heat, and ensure the cap is tightly closed when not in use.

Motufe is a nasal spray. The patient gently inserts the tip into one nostril, closes the opposite nostril, and sprays the prescribed number of sprays while breathing in gently. The same procedure is repeated in the other nostril if directed by the prescriber.

Serious risks, though rare, include nasal septal perforation, severe allergic reactions such as anaphylaxis, vision changes like cataracts or glaucoma, and systemic adrenal suppression with prolonged high‑dose use. Patients should seek medical attention if they notice any of these symptoms.

Motufe should be avoided in individuals with a known hypersensitivity to fluticasone furoate, other corticosteroids, or any component of the formulation. It is also contraindicated in patients with active untreated nasal infections until the infection is resolved.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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