Motusol Max 12-Hour Pain Relief (Diclofenac Diethylamine)

Diclofenac Diethylamine is applied topically to manage pain and inflammation within the musculoskeletal system.

• Musculoskeletal pain: provides relief of mild to moderate pain in muscles and joints.
• Sports injuries: reduces pain and swelling associated with strains and sprains.
• Post‑traumatic sprains: alleviates discomfort and local inflammation.
• Localized osteoarthritis: helps manage joint pain in affected areas.
• Localized rheumatoid arthritis flare: reduces inflammation and tenderness at the site of application.

• Diclofenac Diethylamine penetrates the skin and reversibly inhibits cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, decreasing the synthesis of prostaglandins that mediate inflammation, pain, and fever. By lowering prostaglandin levels locally, the drug diminishes peripheral sensitisation of nociceptors, resulting in analgesic and anti‑inflammatory effects at the site of application.

Topical diclofenac may cause local skin reactions, though most are mild and reversible.

Common Side Effects

• Skin irritation: mild redness or discomfort at the application site.
• Erythema: localized redness of the skin.
• Pruritus: itching where the gel is applied.
• Burning sensation: transient warmth or stinging.
• Dry skin: occasional dryness or flaking.
• Contact dermatitis: mild allergic skin response.

Serious or Rare Side Effects

• Anaphylaxis: severe allergic reaction requiring immediate medical attention.
• Stevens‑Johnson syndrome: rare but serious skin disorder.
• Toxic epidermal necrolysis: life‑threatening skin detachment.
• Systemic NSAID toxicity: rare systemic effects if absorbed in large amounts.
• Severe photosensitivity: heightened skin reaction to sunlight.
• Ulceration: rare skin ulcer formation at the site.

When using topical diclofenac, consider the following safety measures.

• Pregnancy: avoid use unless the prescriber determines benefits outweigh risks.
• Breastfeeding: consult a healthcare professional before application.
• Concomitant anticoagulants: monitor for increased bleeding tendency.
• Skin integrity: do not apply to broken, infected, or irritated skin.
• NSAID allergy: contraindicated in patients with known hypersensitivity to diclofenac or other NSAIDs.
• Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Topical diclofenac can interact with systemic medications; awareness of these interactions helps minimise risk.

Major Interactions (Avoid)

• Oral anticoagulants: may increase bleeding risk.
• Systemic NSAIDs: additive toxicity and gastrointestinal risk.
• Lithium: potential for increased lithium serum levels.

Moderate Interactions (Monitor Closely)

• ACE inhibitors: possible alteration of renal function.
• Diuretics: heightened risk of renal impairment.
• Methotrexate: enhanced toxicity when combined with NSAIDs.