Product image of Motusol Max 12-Hour Pain Relief (Diclofenac Sodium) supplied by GNH India

Motusol Max 12-Hour Pain Relief

Active Ingredient:
Diclofenac Sodium
Origin:
EU

Motusol Max 12-Hour Pain Relief (Diclofenac Sodium)

Diclofenac sodium, the active ingredient in Motusol Max 12-Hour Pain Relief, is a nonsteroidal anti‑inflammatory drug (NSAID) presented as a topical gel for cutaneous use. It is employed to relieve pain and reduce inflammation in musculoskeletal conditions, providing up to twelve hours of localized effect for adult patients.

GNH India supplies Motusol Max 12-Hour Pain Relief as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation to support import and distribution across multiple regions.

Manufacturer / TM Owner

Teva Uk Limited

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Indications & Clinical Uses

  • Diclofenac sodium is an NSAID that acts on inflammatory pathways to alleviate pain in various musculoskeletal conditions.
  • Musculoskeletal pain: provides localized analgesia and reduces inflammation in strains, sprains and overuse injuries.
  • Osteoarthritis of the knee: diminishes joint pain and stiffness, improving functional mobility.
  • Rheumatoid arthritis flare-ups: alleviates localized swelling and tenderness in affected joints.
  • Post‑operative incision sites: reduces superficial inflammation and discomfort after minor surgical procedures.
  • Acute soft‑tissue injuries: eases pain and edema in bruises and contusions.

How It Works

  • Diclofenac sodium exerts its anti‑inflammatory and analgesic effects by non‑selectively inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes. This inhibition blocks the conversion of arachidonic acid to prostaglandins, which are mediators of inflammation, pain and fever. By reducing prostaglandin synthesis at the site of application, the topical formulation limits local vascular permeability and nociceptor activation, delivering sustained relief without significant systemic exposure.

Side Effects

Topical diclofenac may cause local and systemic adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Skin irritation: mild redness or itching at the application site
  • Burning sensation: transient warmth or stinging
  • Dryness: localized dry skin
  • Pruritus: itching without rash
  • Erythema: mild redness
  • Contact dermatitis: localized rash with possible vesicles

Serious or Rare Side Effects

  • Severe allergic reaction: angioedema, swelling of face or throat
  • Stevens‑Johnson syndrome: extensive skin blistering and detachment
  • Systemic NSAID toxicity: gastrointestinal ulceration, renal impairment, or hepatic enzyme elevation
  • Photosensitivity: heightened skin reaction to sunlight
  • Necrotizing skin reactions: rare cases of skin necrosis at the site of application

Precautions & Warnings

  • Before using Motusol Max 12-Hour Pain Relief, consider the following safety measures.
  • Assess renal function: avoid use in patients with severe renal impairment
  • Evaluate cardiovascular risk: use cautiously in those with heart disease or hypertension
  • Avoid on infected or broken skin: may increase systemic absorption
  • Use with caution in asthma: NSAIDs can trigger bronchospasm
  • Do not combine with other NSAIDs or systemic analgesics: increased risk of adverse events
  • Store at room temperature: keep in original packaging, protect from moisture and direct sunlight

Avoid Interactions

Diclofenac sodium can interact with several systemic medicines; awareness helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased bleeding risk
  • Other NSAIDs or COX‑2 inhibitors: additive gastrointestinal toxicity
  • Lithium: elevated serum lithium levels

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: possible renal function decline
  • Selective serotonin reuptake inhibitors (SSRIs): modest increase in bleeding risk

Frequently Asked Questions

Motusol Max 12-Hour Pain Relief is a topical formulation of diclofenac sodium designed to provide localized relief of pain and inflammation associated with musculoskeletal conditions such as strains, sprains, osteoarthritis, and soft‑tissue injuries. It is applied to the skin over the affected area to achieve up to twelve hours of analgesic effect.

Diclofenac sodium works by non‑selectively inhibiting the cyclooxygenase enzymes COX‑1 and COX‑2, which are essential for converting arachidonic acid into prostaglandins. By reducing prostaglandin synthesis at the site of application, the gel diminishes inflammation, pain signaling, and vascular changes, delivering targeted relief without substantial systemic exposure.

The appropriate dose and frequency are determined by the prescribing healthcare professional based on the severity of the condition, the size of the treatment area, and patient‑specific factors. Patients should follow the prescriber’s instructions and the product label for the amount to apply and the interval between applications.

Safety data for topical diclofenac in pregnancy and lactation are limited. Healthcare providers generally advise caution and may recommend alternative therapies unless the potential benefit outweighs the risk. Women who are pregnant, planning pregnancy, or breastfeeding should discuss use with their physician before starting treatment.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide, and will request verification of trade or institutional credentials. The sales team then replies with pricing, availability, shipping details (including any cold‑chain requirements), and the necessary import documentation.

Motusol Max contains diclofenac sodium, a widely studied NSAID with strong COX inhibition. Compared with other topical NSAIDs such as ibuprofen or ketoprofen gels, diclofenac generally offers a longer duration of action (up to twelve hours) and a well‑characterised safety profile. Choice of product should consider the specific indication, patient tolerance, and prescriber preference.

Store the gel at room temperature, preferably below 25 °C. Keep the container tightly closed, in its original packaging, and protect it from moisture, direct sunlight, and extreme heat. Do not freeze the product, as low temperatures may affect its consistency and efficacy.

The gel is applied topically to clean, dry skin over the painful or inflamed area. A thin layer is spread gently and allowed to absorb; the area should not be covered with occlusive dressings unless directed by a healthcare professional. Hands should be washed after application to avoid accidental contact with eyes or mucous membranes.

Serious risks include severe allergic reactions such as angioedema, Stevens‑Johnson syndrome, and necrotizing skin reactions. Systemic NSAID toxicity, though rare with topical use, can manifest as gastrointestinal ulceration, renal impairment, or hepatic enzyme elevation, especially in patients with pre‑existing organ dysfunction or when used with interacting medicines.

Individuals with known hypersensitivity to diclofenac, other NSAIDs, or any component of the formulation should avoid this product. It is also contraindicated on infected, broken, or ulcerated skin, and in patients with severe renal, hepatic, or cardiovascular disease unless specifically advised by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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