Product image of Movalis (Meloxicam) supplied by GNH India

Movalis

Active Ingredient:
Meloxicam
Origin:
EU

Movalis (Meloxicam)

Meloxicam, the active ingredient in Movalis, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an intramuscular injection for intramuscular use. It is indicated for the management of osteoarthritis, rheumatoid arthritis, acute musculoskeletal pain, and post‑operative pain in adult patients, providing anti‑inflammatory and analgesic effects through COX‑2 inhibition.

GNH India supplies Movalis as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with capabilities for bulk manufacturing, quality assurance, and regulatory support across EU and global markets and distribution.

Manufacturer / TM Owner

Boehringer Ingelheim Portugal, Lda.

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Indications & Clinical Uses

  • Meloxicam is an NSAID that reduces inflammation and pain in musculoskeletal disorders.
  • Osteoarthritis: reduces joint pain, swelling, and improves functional mobility in patients with degenerative joint disease by decreasing prostaglandin‑mediated inflammation.
  • Rheumatoid arthritis: alleviates chronic synovial inflammation, pain, and joint damage progression in adult patients through COX‑2 inhibition.
  • Acute musculoskeletal pain: provides rapid analgesia and reduces inflammation after injuries such as sprains, strains, or contusions.
  • Post‑operative pain: controls moderate to severe pain following surgical procedures, facilitating early mobilization and recovery.

How It Works

  • Meloxicam preferentially inhibits the cyclooxygenase‑2 (COX‑2) enzyme, which catalyzes the conversion of arachidonic acid to prostaglandins that mediate inflammation, pain and fever. By blocking COX‑2 more than COX‑1, it reduces prostaglandin synthesis at sites of inflammation while preserving gastric prostaglandins, resulting in anti‑inflammatory, analgesic and antipyretic effects. The inhibition is dose‑dependent and contributes to decreased vascular permeability and leukocyte infiltration in inflamed tissues.

Side Effects

Meloxicam may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Injection site pain
  • Nausea or dyspepsia
  • Headache
  • Dizziness

Serious or Rare Side Effects

  • Gastrointestinal ulcer or bleeding
  • Severe allergic reaction (anaphylaxis)
  • Liver enzyme elevation
  • Renal impairment

Precautions & Warnings

Precautions should be observed when prescribing or administering Movalis.

  • Renal function: monitor in patients with existing kidney disease.
  • Cardiovascular risk: use cautiously in patients with heart disease or hypertension.
  • Gastrointestinal risk: avoid in patients with active peptic ulcer disease.
  • Pregnancy and lactation: contraindicated unless benefits outweigh risks.
  • Concomitant anticoagulants: increased bleeding risk; monitor coagulation parameters.
  • Store at ambient temperature: keep in original packaging, protect from moisture and light.

Avoid Interactions

Meloxicam can interact with several medicines; awareness of the interaction level is important.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of serious bleeding.
  • ACE inhibitors or ARBs: may reduce renal function when combined.
  • Lithium: meloxicam can raise serum lithium levels, risking toxicity.
  • Methotrexate: increased methotrexate toxicity.

Moderate Interactions (Monitor Closely)

  • Diuretics: potential for reduced renal clearance.
  • SSRIs or SNRIs: heightened bleeding tendency.
  • Corticosteroids: additive risk of gastrointestinal ulceration.

Frequently Asked Questions

Movalis is the brand name for the injectable form of meloxicam, an NSAID indicated for the treatment of inflammatory conditions such as osteoarthritis, rheumatoid arthritis, acute musculoskeletal pain, and pain following surgery. It works by reducing inflammation and providing analgesia, and is prescribed by healthcare professionals for adult patients who require rapid pain control.

Meloxicam works by preferentially inhibiting the cyclooxygenase‑2 (COX‑2) enzyme, which is responsible for converting arachidonic acid into prostaglandins that promote inflammation, pain, and fever. By blocking COX‑2 more than COX‑1, meloxicam decreases prostaglandin production at sites of inflammation while preserving protective gastric prostaglandins, resulting in anti‑inflammatory and analgesic effects.

The dosage of Movalis is determined by the prescribing clinician based on the patient’s condition, severity of pain, and individual health factors. The healthcare provider selects the appropriate amount and frequency of the intramuscular injection, and patients should follow the prescribed regimen without alteration.

The safety of meloxicam in pregnancy and lactation has not been established, and it is generally avoided unless the potential benefit justifies the potential risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their healthcare provider.

To place an order, submit an enquiry on the Movalis product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if required) and necessary import documentation.

Compared with non‑selective NSAIDs, meloxicam offers a higher selectivity for COX‑2, which may reduce the incidence of gastrointestinal side effects while still providing effective anti‑inflammatory and analgesic action. However, it shares similar cardiovascular and renal risk profiles with other NSAIDs, and the choice of therapy depends on individual patient risk factors and clinical judgment.

Movalis for intramuscular injection should be stored at controlled room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Do not freeze the product. Before administration, inspect the vial for particulate matter or discoloration and follow aseptic techniques as recommended in the product’s prescribing information.

Movalis is supplied as a sterile solution for intramuscular injection. A qualified healthcare professional administers the dose into a suitable muscle, typically the gluteal or deltoid region, using aseptic technique. The injection site should be rotated as appropriate, and the patient should be observed for any immediate adverse reactions following administration.

The most serious risks include gastrointestinal ulceration or bleeding, severe allergic reactions such as anaphylaxis, liver injury, renal impairment, and cardiovascular events like myocardial infarction or stroke. Patients with a history of ulcer disease, heart failure, kidney disease, or those taking anticoagulants should be monitored closely, and any signs of serious adverse effects require immediate medical attention.

Movalis should not be used in patients with known hypersensitivity to meloxicam or other NSAIDs, active gastrointestinal ulcer disease, severe renal or hepatic impairment, uncontrolled hypertension, or in the third trimester of pregnancy. It is also contraindicated in individuals receiving certain anticoagulants or those with a history of cardiovascular events unless the prescribing physician determines that the benefits outweigh the risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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