Product image of Moventig (Naloxegol) supplied by GNH India

Moventig

Active Ingredient:
Naloxegol
Origin:
EU

Moventig (Naloxegol)

Naloxegol, the active ingredient in Moventig, is a peripheral opioid antagonist presented as an oral tablet for oral use. It selectively blocks μ‑opioid receptors in the gastrointestinal tract, helping to restore normal bowel motility in patients who develop constipation as a side effect of opioid analgesics.

GNH India supplies Moventig as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing reliable access to this EU‑approved medication for healthcare providers. The company adheres to stringent quality standards and offers comprehensive logistics support for global distribution.

Manufacturer / TM Owner

Grünenthal Gmbh

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Indications & Clinical Uses

  • Moventig (naloxegol) is used to manage opioid‑induced constipation, a condition caused by reduced gastrointestinal motility during opioid therapy.
  • Opioid‑induced constipation: Improves bowel movements and reduces stool retention in patients receiving opioid analgesics.

How It Works

  • Naloxegol acts as a selective antagonist of peripheral μ‑opioid receptors located in the gastrointestinal smooth muscle. By binding to these receptors without activating them, it prevents opioid‑mediated inhibition of intestinal peristalsis, thereby restoring normal transit and facilitating stool formation. The molecule is designed to have limited ability to cross the blood‑brain barrier, preserving central analgesic effects while targeting only peripheral sites.

Side Effects

Naloxegol may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Abdominal pain
  • Diarrhea
  • Nausea
  • Flatulence
  • Headache
  • Vomiting

Serious or Rare Side Effects

  • Intestinal obstruction
  • Severe abdominal pain
  • Allergic reactions such as rash or angioedema
  • Pancreatitis
  • Severe dehydration
  • Elevated liver enzymes

Precautions & Warnings

Before prescribing Moventig, clinicians should evaluate patient-specific factors and monitor for potential complications.

  • Assess bowel function before initiating therapy: confirm that constipation is opioid‑related and not due to other causes.
  • Avoid use in patients with known or suspected mechanical gastrointestinal obstruction: naloxegol can exacerbate blockage.
  • Monitor for signs of dehydration or electrolyte imbalance: adjust fluid intake as needed.
  • Use caution in patients with hepatic impairment: dose adjustment may be required.
  • Store at ambient temperature below 25°C: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Naloxegol interacts with several drug classes that affect its metabolism or transport.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin, ritonavir): may increase naloxegol exposure and risk of toxicity.
  • Concomitant use with other peripheral opioid antagonists: can lead to additive adverse gastrointestinal effects.

Moderate Interactions (Monitor Closely)

  • Moderate CYP3A4 inhibitors (e.g., erythromycin, fluconazole): may require dose adjustment.
  • CYP3A4 inducers (e.g., rifampin, carbamazepine): may reduce efficacy of naloxegol.
  • P‑gp inhibitors (e.g., verapamil, amiodarone): can increase systemic concentrations of naloxegol.

Frequently Asked Questions

Moventig contains naloxegol and is prescribed to treat opioid‑induced constipation. It is intended for patients who experience reduced bowel motility as a side effect of opioid analgesic therapy, helping to restore regular stool passage without affecting pain control.

Naloxegol selectively blocks peripheral μ‑opioid receptors in the gastrointestinal tract. By preventing opioids from inhibiting intestinal peristalsis, it restores normal motility and facilitates stool formation while leaving central opioid receptors untouched, so pain relief is maintained.

The dose of Moventig is determined by the prescribing healthcare professional based on the patient’s clinical condition, opioid regimen, and other individual factors. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for naloxegol during pregnancy and lactation are limited. The product is classified as pregnancy category unknown, so it should only be used if the potential benefit justifies the potential risk. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their healthcare provider.

To request Moventig, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

The primary alternative to naloxegol is methylnaltrexone, another peripheral opioid antagonist. Both agents aim to relieve opioid‑induced constipation, but naloxegol is an oral tablet while methylnaltrexone is administered subcutaneously. Choice between them often depends on patient preference, route of administration, and specific safety considerations.

Moventig tablets should be stored at ambient temperature below 25 °C, in the original container, protected from moisture and direct sunlight. Keep the product out of reach of children and do not use after the expiry date printed on the packaging.

Moventig is taken orally, usually with a full glass of water. The tablet should be swallowed whole and not crushed, chewed, or split, to ensure proper absorption and maintain its intended release characteristics.

Serious adverse events associated with naloxegol include intestinal obstruction, severe abdominal pain, allergic reactions such as rash or angioedema, pancreatitis, and significant dehydration. Patients should seek immediate medical attention if they experience any of these symptoms.

Moventig is contraindicated in patients with known or suspected mechanical gastrointestinal obstruction, severe hepatic impairment, or those taking strong CYP3A4 inhibitors. It should also be avoided in individuals with a history of hypersensitivity to naloxegol or any of the tablet’s excipients.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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