Product image of Moventig (Naloxegol) supplied by GNH India

Moventig

Active Ingredient:
Naloxegol
Origin:
EU

Moventig (Naloxegol)

Naloxegol, the active ingredient in Moventig, is a peripherally acting µ‑opioid receptor antagonist presented as an oral tablet. It is indicated for the treatment of opioid‑induced constipation in adults who are receiving opioid therapy for chronic pain, helping to restore normal bowel function without compromising analgesia.

GNH India supplies Moventig as a licensed, GDP‑compliant international pharmaceutical supplier, providing the product to hospitals, pharmacies and clinics worldwide under strict quality standards. The company adheres to EU GMP guidelines and offers reliable logistics for timely delivery across multiple regions.

Manufacturer / TM Owner

Grünenthal Limited

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Indications & Clinical Uses

Naloxegol is used to manage opioid‑induced constipation, a gastrointestinal side effect of opioid therapy.

  • Opioid‑induced constipation in chronic non‑cancer pain: increases bowel movement frequency and improves stool consistency.
  • Opioid‑induced constipation in cancer pain: reduces constipation severity and enhances patient comfort.
  • Opioid‑induced constipation in postoperative pain management: facilitates gastrointestinal recovery and normalizes bowel habits.

How It Works

  • Naloxegol selectively antagonizes peripheral µ‑opioid receptors located in the gastrointestinal tract. By blocking these receptors, it counteracts the constipating effects of opioids on intestinal motility while preserving central opioid analgesia, thereby normalizing bowel function without diminishing pain control.

Side Effects

Naloxegol may cause adverse reactions that vary in frequency and severity.

Common Side Effects

  • Abdominal pain: mild to moderate discomfort in the stomach area.
  • Diarrhea: increased frequency of loose stools.
  • Nausea: feeling of queasiness or urge to vomit.
  • Headache: mild to moderate head pain.

Serious or Rare Side Effects

  • Intestinal obstruction: signs of severe abdominal pain and bloating.
  • Severe allergic reaction: rash, swelling, or difficulty breathing.
  • Elevated liver enzymes: abnormal blood test indicating possible liver stress.

Precautions & Warnings

Before initiating therapy with Naloxegol, consider the following precautions.

  • Assess renal function: dose adjustment may be required in severe renal impairment.
  • Avoid strong CYP3A4 inhibitors: concomitant use can increase drug exposure.
  • Monitor for signs of bowel obstruction: discontinue if obstruction is suspected.
  • Use with caution in patients with existing gastrointestinal disorders: evaluate risk versus benefit.
  • Store at ambient temperature: keep in the original pack, protect from moisture and light.

Avoid Interactions

Naloxegol can interact with other medicines; awareness of interaction severity is essential.

Major Interactions (Avoid)

  • Ketoconazole (strong CYP3A4 inhibitor): avoid co‑administration.
  • Ritonavir (strong CYP3A4 inhibitor): avoid co‑administration.

Moderate Interactions (Monitor Closely)

  • Rifampin (CYP3A4 inducer): may reduce Naloxegol efficacy.
  • Diltiazem (moderate CYP3A4 inhibitor): may increase Naloxegol levels.
  • Anticholinergic agents: may exacerbate constipation symptoms.

Frequently Asked Questions

Moventig contains Naloxegol, which is prescribed to treat opioid‑induced constipation in adults receiving opioid therapy. It works by targeting peripheral opioid receptors in the gut to restore normal bowel movements without affecting pain relief.

Naloxegol selectively blocks µ‑opioid receptors located in the gastrointestinal tract. This antagonism reverses the constipating effect of opioids on intestinal motility while leaving central opioid receptors untouched, allowing patients to maintain analgesia while improving bowel function.

The dosage of Moventig is determined by the prescribing healthcare professional based on the patient’s clinical condition, opioid regimen, and renal function. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for Naloxegol in pregnancy and lactation are limited. The medication should only be used if the potential benefit justifies any possible risk to the fetus or infant, and this decision must be made by a qualified healthcare provider.

To request Moventig, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Moventig (Naloxegol) is a peripherally acting µ‑opioid receptor antagonist, differing from laxatives or stool softeners that act locally. Compared with other antagonists such as methylnaltrexone, Naloxegol is administered orally and does not require injection, offering a convenient option for many patients.

Store Moventig tablets at ambient temperature, below 25 °C. Keep them in the original packaging to protect from moisture and light. Do not store in extreme heat or humidity, and keep out of reach of children.

Moventig is taken orally as a tablet, usually on an empty stomach at least one hour before or two hours after the first dose of an opioid analgesic. The tablet should be swallowed whole with a glass of water and not chewed or crushed.

Serious risks include possible intestinal obstruction, severe abdominal pain, allergic reactions such as rash or swelling, and rare liver enzyme elevations. Patients should seek immediate medical attention if they experience any signs of obstruction or severe hypersensitivity.

Moventig is contraindicated in patients with known hypersensitivity to Naloxegol or any of its excipients, and in those taking strong CYP3A4 inhibitors such as ketoconazole or ritonavir. Caution is also advised for individuals with severe renal impairment or existing gastrointestinal obstruction.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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