Product image of Movicol Neutral (Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350) supplied by GNH India

Movicol Neutral

Active Ingredient:
Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350
Origin:
EU

Movicol Neutral (Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350)

Macrogol 3350, the active ingredient in Movicol Neutral, is an osmotic laxative presented as an oral solution for oral use. The formulation also contains sodium hydrogen carbonate, potassium chloride and sodium chloride to provide electrolyte balance while drawing water into the intestinal lumen. It is used to relieve constipation in adults and children when dietary measures and other non‑pharmacologic options have not been sufficient. The osmotic action increases stool water content, facilitating softer stools and promoting peristaltic activity.

GNH India supplies Movicol Neutral as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Norgine Healthcare B.V.

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Indications & Clinical Uses

  • Movicol Neutral, an osmotic laxative, works on the gastrointestinal tract to alleviate constipation.
  • Constipation: softens stool and promotes regular bowel movements in adults and children.
  • Chronic constipation: provides sustained osmotic effect to maintain stool softness over longer periods.
  • Opioid‑induced constipation: counteracts opioid‑related reduction in gut motility by increasing intestinal water content.

How It Works

  • Macrogol 3350 is a high‑molecular‑weight polyethylene glycol that is not absorbed from the gut. It creates an osmotic gradient in the intestinal lumen, retaining water and electrolytes within the bowel. The increased fluid softens the fecal mass and expands stool volume, which stimulates stretch receptors and enhances peristaltic activity, facilitating bowel evacuation.

Side Effects

Movicol Neutral may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Abdominal bloating
  • Flatulence
  • Nausea
  • Abdominal cramps
  • Diarrhea
  • Headache

Serious or Rare Side Effects

  • Severe electrolyte imbalance
  • Dehydration
  • Allergic reaction (rash, itching, swelling)
  • Severe abdominal pain
  • Rectal bleeding

Precautions & Warnings

  • When using Movicol Neutral, consider the following precautions.
  • Assess renal function: adjust use in patients with severe renal impairment.
  • Monitor electrolytes: prolonged use may affect sodium or potassium levels.
  • Use with caution in elderly: increased risk of dehydration.
  • Avoid in patients with known hypersensitivity to any component.
  • Pregnancy and lactation: consult a healthcare professional before use.
  • Store at ambient temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Potential drug interactions with Movicol Neutral should be reviewed.

Major Interactions (Avoid)

  • Diuretics: concurrent use may exacerbate electrolyte disturbances.
  • Lithium: increased risk of lithium toxicity due to altered renal clearance.
  • Other osmotic laxatives: additive effect may cause severe diarrhea and dehydration.

Moderate Interactions (Monitor Closely)

  • Antacids containing magnesium or aluminum: may reduce laxative efficacy.
  • Oral rehydration solutions: monitor electrolyte balance.
  • Medications requiring stable plasma levels (e.g., digoxin): watch for shifts in electrolytes.

Frequently Asked Questions

Movicol Neutral is an oral osmotic laxative used to treat constipation. It works by increasing the water content of stool, making it softer and easier to pass, and is indicated for adults and children when other measures have not provided adequate relief.

Macrogol 3350 is a high‑molecular‑weight polyethylene glycol that remains in the intestinal lumen. It creates an osmotic gradient that draws water into the bowel, softening stool and expanding its volume, which stimulates peristalsis and promotes bowel evacuation.

The dose of Movicol Neutral is individualized by the prescribing healthcare professional. The prescriber considers factors such as the patient’s age, severity of constipation, renal function, and response to therapy before setting the appropriate dosage.

Safety data for Movicol Neutral in pregnancy and lactation are limited. Healthcare providers should evaluate the potential benefits against any possible risks before prescribing it to pregnant or breastfeeding women.

To order Movicol Neutral, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Movicol Neutral belongs to the osmotic laxative class, which works by retaining water in the bowel. This differs from stimulant laxatives that increase intestinal motility directly. Osmotic agents are generally gentler and suitable for longer‑term use, whereas stimulants may cause cramping and are often reserved for occasional relief.

Store Movicol Neutral at ambient temperature, preferably below 25 °C. Keep the solution in its original container, protect it from moisture and direct sunlight, and ensure the bottle is tightly closed when not in use.

Movicol Neutral is taken orally as a liquid solution. The prescribed amount is usually mixed with a measured volume of water, stirred until fully dissolved, and consumed promptly. Patients should follow the specific instructions provided by their healthcare professional.

Serious risks associated with Movicol Neutral include severe electrolyte imbalance, dehydration, and allergic reactions such as rash, itching or swelling. If any of these occur, medical attention should be sought immediately.

Movicol Neutral should be avoided in individuals with known hypersensitivity to any of its components, in patients with severe renal impairment, and in those with intestinal obstruction or perforation unless directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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